Biotherapeutics Translational Research Center (바이오신약중개연구센터)515

연구분야

  • 암/혈관신생/혈관염증 조절 표적 발굴 및 제어 기술 개발
    • 다기능 항체 라이브러리 시스템 기반 표적 발굴 및 항체 개발
    • 줄기세포 기반 혈관내피분화조절
  • 약제내성 및 암전이 조절 규명 및 제어 기술 개발
    • 기초-임상 중개연구를 통한 신약개발
  • 암 특이적 세포대사-신호를 표적으로 한 질환 치료제 개발 및 적용기술 개발연구
    • 암세포 대사체 젖산의 역할 및 작용기전 연구
    • 젖산 신호전달체계 조절을 통한 질환 치료기술 연구
  • 면역결핍돼지 생산에 관련한 유전자 발굴
    • 면역거부반응을 일으키는 인자에 대한 메커니즘 연구
  • 질환동물 생산 및 기능적 연구
    • Gene editing system을 이용한 유전자 결손 및 변이 동물 생산
    • 동물모델을 이용한 분자유전학적 및 생리학적 기능에 대한 연구
더보기

Showing results 201 to 220 of 256

No. Year Title Type
201 2012

2012Article

An efficient strategy for cell-based antibody library selection using an integrated vector systemBMC Biotechnology, vol. 12, pp. 62-62Hyerim Yoon; Jin Myung Song; C J Ryu; Yeon Gu KimEun Gyo LeeSunghyun KangSang Jick Kim
Article
202 2012

2012Article

Effect of mitochondrial and ER-targeted Bcl-2 overexpression on apoptosis in recombinant Chinese hamster ovary cells treated with sodium butyrateProcess Biochemistry, vol. 47, no. 12, pp. 2518-2522Yeon Gu Kim; B Park; Seungwoon Lee; Jungoh Ahn; Joon Ki Jung; Hong-Weon Lee; G M Lee; Eun Gyo Lee
Article
203 2012

2012Article

Enforced expression of roquin protein in T cells exacerbates the incidence and severity of experimental arthritisJournal of Biological Chemistry, vol. 287, no. 50, pp. 42269-42277Y R Ji; H J Kim; D H Yu; K B Bae; S J Park; J K Yi; N Kim; S J Park; K B Oh; S S Hwang, et al.
Article
204 2012

2012Article

Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cellsBMB Reports, vol. 45, no. 12, pp. 713-718J S Ryu; Kyu Tae Chang; J T Lee; M U Lim; H K Min; Y J Na; S B Lee; G Moussavou; Sun-Uk KimJi Su Kim, et al.
Article
205 2012

2012Article

Effect of porcine follicular fluid on donor cell characteristics and quality of porcine cloned blastocystsReproductive & Developmental Biology, vol. 36, no. 4, pp. 249-254D J Kwon; K B Oh; S A Ock; Jeong Woong Lee; S S Lee; J K Park; W K Chang; S Hwang
Article
206 2012

2012Article

New cell line development for antibody-producing Chinese hamster ovary cells using split green fluorescent protein = 분열형광 단백질을 이용한 신규 치료용 항체 생산 세포주 선별법BMC Biotechnology, vol. 12, no. 1, pp. 24-24Yeon Gu Kim; Byoung-Woo Park; Jungoh Ahn; Joon Ki Jung; Hong-Weon LeeEun Gyo Lee
Article
207 2012

2012Article

Inheritance of mitochondrial DNA in serially recloned pigs by somatic cell nuclear transfer (SCNT)Biochemical and Biophysical Research Communications, vol. 424, no. 3, pp. 765-770Minhwa Do; Won-Gu Jang; J H Hwang; Hoon Jang; Eun Jung Kim; Eun Jeong Jeong; H Shim; S S Hwang; K B Oh; S J Byun, et al.
Article
208 2012

2012Article

CHO cells in biotechnology for production of recombinant proteins: current state and further potential = 치료용 단백질 생산을 위한 CHO세포의 연구 성과와 미래 연구 방향Applied Microbiology and Biotechnology, vol. 93, no. 3, pp. 917-930J Y Kim; Yeon Gu Kim; G M Lee
Article
209 2012

2012Article

Differential in-gel electrophoresis (DIGE) analysis of CHO cells under hyperosmotic pressure: Osmoprotective effect of glycine betaine additionBiotechnology and Bioengineering, vol. 109, no. 6, pp. 1395-1403J Y Kim; Yeon Gu Kim; G M Lee
Article
210 2012

2012Article

A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma modelExperimental and Molecular Medicine, vol. 44, no. 4, pp. 293-302E S Lee; M S Jeong; R Singh; Juyeon Jung; Hyunho Yoon; Jeong Ki Min; K H Kim; H J Hong
Article
211 2012

2012Article

Aberrant L1 cell adhesion molecule affects tumor behavior and chemosensitivity in anaplastic thyroid carcinomaClinical Cancer Research, vol. 18, no. 11, pp. 3071-3078K S Kim; Jeong Ki Min; Z L Liang; Gyungmin Lee; J U Lee; Kwang-Hee Bae; M H Lee; S E Lee; M J Ryu; S J Kim, et al.
Article
212 2012

2012Article

S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skinBiochemical and Biophysical Research Communications, vol. 423, no. 4, pp. 647-653Y Lee; S Jang; Jeong Ki Min; Kyungmin Lee; K C Sohn; J S Lim; M Im; H E Lee; Y J Seo; C D Kim, et al.
Article
213 2012

2012Article

L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cellsCancer Letters, vol. 316, no. 1, pp. 70-76Hyunho Yoon; Jeong Ki Min; Dong Gwang Lee; D G Kim; Sang Seok Koh; H J Hong
Article
214 2012

2012Article

Chemokine (C-X-C motif) ligand 12 is associated with gallbladder carcinoma progression and is a novel independent poor prognostic factorClinical Cancer Research, vol. 18, no. 12, pp. 3270-3280H J Lee; Gyungmin Lee; Dong Gwang LeeKwang-Hee Bae; Jang Seong Kim; Z L Liang; S M Huang; Y S Oh; H Y Kim; D Y Jo, et al.
Article
215 2012

2012Article

α1,3-galactosyltransferase deficiency in germ-free miniature pigs increases N-glycolylneuraminic acids as the xenoantigenic determinant in pig-human xenotransplantationCellular Reprogramming, vol. 14, no. 4, pp. 353-363J Y Park; M R Park; H T Bui; D N Kwon; M H Kang; M Oh; J W Han; S G Cho; C Park; H Shim, et al.
Article
216 2012

2012Article

Receptor activator of nuclear factor-κB ligand is a novel inducer of myocardial inflammationCardiovascular Research, vol. 94, no. 1, pp. 105-114S Ock; J Ahn; S H Lee; H Park; J W Son; J G Oh; D K Yang; W S Lee; H S Kim; J Rho, et al.
Article
217 2011

2011Article

The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo = 담낭암 진행에서 L1CAM 기능 규명Oncology Reports, vol. 25, no. 4, pp. 945-952Juyeon Jung; Yeon Sung Son; H Park; Seong Kook Jeon; J W Lee; S Y Choi; J M Kim; Y G Kwon; H J Hong; Jeong Ki Min
Article
218 2011

2011Article

Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2 = 담도암에서 항암제 내성 기전규명Biochemical and Biophysical Research Communications, vol. 405, no. 3, pp. 333-337Hyunho Yoon; Jeong Ki Min; J W Lee; D G Kim; H J Hong
Article
219 2011

2011Article

Resurrection of an alpha-1,3-galactosyltransferase gene-targeted miniature pig by recloning using postmortem ear skin fibroblastsTheriogenology, vol. 75, no. 5, pp. 933-939K S Ahn; Y J Kim; M Kim; B H Lee; S Y Heo; M J Kang; Yong-Kook KangJeong Woong Lee; K K Lee; J H Kim, et al.
Article
220 2011

2011Article

Effect of constitutively active ras overexpression on cell growth in recombinant chinese hamster ovary cellsBiotechnology Progress, vol. 27, no. 2, pp. 577-580Yeon Gu Kim; Y K Han; J Y Kim; Eun Gyo LeeHong-Weon Lee; G M Lee
Article
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