Biotherapeutics Translational Research Center (바이오신약중개연구센터)515

연구분야

  • 암/혈관신생/혈관염증 조절 표적 발굴 및 제어 기술 개발
    • 다기능 항체 라이브러리 시스템 기반 표적 발굴 및 항체 개발
    • 줄기세포 기반 혈관내피분화조절
  • 약제내성 및 암전이 조절 규명 및 제어 기술 개발
    • 기초-임상 중개연구를 통한 신약개발
  • 암 특이적 세포대사-신호를 표적으로 한 질환 치료제 개발 및 적용기술 개발연구
    • 암세포 대사체 젖산의 역할 및 작용기전 연구
    • 젖산 신호전달체계 조절을 통한 질환 치료기술 연구
  • 면역결핍돼지 생산에 관련한 유전자 발굴
    • 면역거부반응을 일으키는 인자에 대한 메커니즘 연구
  • 질환동물 생산 및 기능적 연구
    • Gene editing system을 이용한 유전자 결손 및 변이 동물 생산
    • 동물모델을 이용한 분자유전학적 및 생리학적 기능에 대한 연구
더보기

Showing results 61 to 80 of 256

No. Year Title Type
61 2020

2020Article

Protein disulfide isomerase in cardiovascular diseaseExperimental and Molecular Medicine, vol. 52, no. 3, pp. 390-399B Xiong; V Jha; Jeong Ki Min; J Cho
Article
62 2020

2020Article

Ischemia-induced Netrin-4 promotes neovascularization through endothelial progenitor cell activation via Unc-5 Netrin receptor BFASEB Journal, vol. 34, no. 1, pp. 1231-1246Na Geum Lee; I C Jeung; S C Heo; Jinhoi Song; Wooil Kim; Byungtae Hwang; Min-Gi Kwon; Yeon-Gu KimJangwook LeeJong Gil Park, et al.
Article
63 2020

2020Article

RNA-seq based transcriptome analysis of EHMT2 functions in breast cancerBiochemical and Biophysical Research Communications, vol. 524, pp. 672-676Kwangho Kim; Tae Young Ryu; Jea Woon Ryu; Tae Su HanCho Rok JungMi Young SonDae Soo KimHyun Soo Cho
Article
64 2020

2020Article

microRNA-30a arbitrates intestinal-type early gastric carcinogenesis by directly targeting ITGA2Gastric Cancer, vol. 23, no. 4, pp. 600-613J Min; Tae Su Han; Y Sohn; T Shimizu; B Choi; S W Bae; K Hur; S H Kong; Y S Suh; H J Lee, et al.
Article
65 2020

2020Article

The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulationExperimental and Molecular Medicine, vol. 52, no. 11, pp. 1845-1856Inhyub Kim; M Kim; Min Kyung Park; R Naik; J H Park; Bo Kyung Kim; Y Choi; K Y Chang; Mi Sun Won; Hyun Seung Ban, et al.
Article
66 2020

2020Article

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancerProceedings of National Academy of Sciences of United States of America, vol. 117, no. 51, pp. 32433-32442Ji-Yoon Lee; M Nam; H Y Son; K Hyun; S Y Jang; Jong Woo Kim; Min Wook Kim; Y Jung; E Jang; S J Yoon, et al.
Article
67 2020

2020Article

Effects of Leucosporidium-derived ice-binding protein (LeIBP) on bull semen cryopreservationVeterinary Medicine and Science, vol. 6, pp. 447-453Hoon Jang; Hyo-Jin Kwon; W S Sun; S Hwang; I S Hwang; S Kim; J H Lee; S G Lee; Jeong Woong Lee
Article
68 2020

2020Article

Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysmExperimental and Molecular Medicine, vol. 52, no. 9, pp. 1587-1601S J Jeong; Min Ji Cho; N Y Ko; S Kim; I H Jung; Jeong Ki Min; S H Lee; Jong Gil Park; G T Oh
Article
69 2020

2020Article

Intestinal morphogenesis in development, regeneration, and disease: the potential utility of intestinal organoids for studying compartmentalization of the crypt-villus structureFrontiers in Cell and Developmental Biology, vol. 8, pp. 593969-593969Ohman KwonTae Su HanMi Young Son
Article
70 2020

2020Article

The protective effect of Leucosporidium-derived ice-binding protein (LeIBP) on bovine oocytes and embryos during vitrificationTheriogenology, vol. 151, pp. 137-143W S Sun; Hoon Jang; Hyo-Jin Kwon; Ki Young Kim; Soo Bin Ahn; S Hwang; S G Lee; J H Lee; I S Hwang; Jeong Woong Lee
Article
71 2020

2020Article

Combination treatment with GSK126 and pomalidomide induces B-cell differentiation in EZH2 gain-of-function mutant diffuse large B-cell lymphomaCancers, vol. 12, no. 9, pp. 2541-2541Seongryul Park; Seung-Hyun Jo; Jong Hwan KimSeon-Young Kim; J D Ha; J Y Hwang; Myeong Youl LeeJong Soon KangTae Su HanSung Goo Park, et al.
Article
72 2020

2020Article

Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathwaysTheranostics, vol. 10, no. 11, pp. 5048-5063Hana Lee; Ye Seul Son; Mi Ok Lee; Jea Woon Ryu; Kunhyang ParkOhman Kwon; Kwang Bo Jung; Kwangho Kim; Tae Young Ryu; Areum Baek, et al.
Article
73 2020

2020Article

Bacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentinCell Death & Disease, vol. 11, no. 4, pp. 231-231Seung-Ho Park; Sung Jin Yoon; Song Choi; Jun Seob Kim; Moo-Seung LeeSeon-Jin Lee; Sang Hyun Lee; Jeong Ki Min; Mi Young SonChoong-Min Ryu, et al.
Article
74 2020

2020Article

Developmental and degenerative characterization of porcine parthenogenetic fetuses during early pregnancyAnimals, vol. 10, no. 4, pp. 622-622I S Hwang; M R Park; H S Lee; T U Kwak; H Y Son; J K Kang; Jeong Woong Lee; K Lee; E W Park; S Hwang
Article
75 2020

2020Article

LAD1 expression is associated with the metastatic potential of colorectal cancer cellsBMC Cancer, vol. 20, pp. 1180-1180Byul Moon; Suk-Jin Yang; Seong Min Park; Sang-Hyun Lee; K S Song; Eun-Jeong Jeong; Mijin Park; Jang Seong Kim; Young Il Yeom; Jung Ae Kim
Article
76 2020

2020Article

Selective elimination of human pluripotent stem cells by Anti-Dsg2 antibody-doxorubicin conjugatesBiomaterials, vol. 259, pp. 120265-120265Jongjin Park; Na Geum Lee; Mihee Oh; Jinhoi Song; Wooil Kim; Min-Gi Kwon; Seul Gi Kim; Baek Soo HanKwang-Hee BaeDong Gwang Lee, et al.
Article
77 2020

2020Article

Maturation of human intestinal organoids in vitro facilitates colonization by commensal lactobacilli by reinforcing the mucus layerFASEB Journal, vol. 34, no. 8, pp. 9899-9910Ye Seul Son; Soo Jin Ki; R Thanavel; Jong-Jin Kim; Mi Ok LeeJanghwan KimCho Rok JungTae Su HanHyun Soo ChoChoong-Min Ryu, et al.
Article
78 2020

2020Article

Epigenetic associations between lncRNA/circRNA and miRNA in hepatocellular carcinomaCancers, vol. 12, no. 9, pp. 2622-2622Tae Su Han; K Hur; Hyun Soo ChoHyun Seung Ban
Article
79 2019

2019Article

PI3K/AKT/β-catenin signaling regulates vestigial-like 1 which predicts poor prognosis and enhances malignant phenotype in gastric cancer = PI3K/AKT/β-catenin 신호전달이 위암 악성화에 관여하는 VGLL1 조절에 기여Cancers, vol. 11, pp. 1923-1923Bo Kyung Kim; J H Cheong; Joo-Young ImHyun Seung BanSeon-Kyu KimMi-Jung KangJungwoon LeeSeon-Young KimKyung Chan Park; S Paik, et al.
Article
80 2019

2019Article

SPAM1/HYAL5 double deficiency in male mice leads to severe male subfertility caused by a cumulus-oocyte complex penetration defectFASEB Journal, vol. 33, no. 12, pp. 14440-14449S Park; Young-Hyun Kim; Pil Soo Jeong; C Park; Jeong Woong Lee; J S Kim; G Wee; Bong-Seok Song; B J Park; S H Kim, et al.
Article
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