Biotherapeutics Translational Research Center (바이오신약중개연구센터)507

연구분야

  • 암/혈관신생/혈관염증 조절 표적 발굴 및 제어 기술 개발
    • 다기능 항체 라이브러리 시스템 기반 표적 발굴 및 항체 개발
    • 줄기세포 기반 혈관내피분화조절
  • 약제내성 및 암전이 조절 규명 및 제어 기술 개발
    • 기초-임상 중개연구를 통한 신약개발
  • 암 특이적 세포대사-신호를 표적으로 한 질환 치료제 개발 및 적용기술 개발연구
    • 암세포 대사체 젖산의 역할 및 작용기전 연구
    • 젖산 신호전달체계 조절을 통한 질환 치료기술 연구
  • 면역결핍돼지 생산에 관련한 유전자 발굴
    • 면역거부반응을 일으키는 인자에 대한 메커니즘 연구
  • 질환동물 생산 및 기능적 연구
    • Gene editing system을 이용한 유전자 결손 및 변이 동물 생산
    • 동물모델을 이용한 분자유전학적 및 생리학적 기능에 대한 연구
더보기

Showing results 1 to 20 of 237

No. Year Title Type
1 2022

2022Article

Development of an in vitro screening system for synthetic signal peptide in mammalian cell?based protein productionApplied Microbiology and Biotechnology, vol. 106, no. 9, pp. 3571-3582Jong-Ho Park; Hoon Min Lee; Eun-Ju Jin; Eun-Ji Lee; Yeon Ju Kang; S Kim; S S Yoo; G M Lee; Yeon-Gu Kim
Article
2 2022

2022Article

Pathological and genomic findings of Erysipelothrix rhusiopathiae isolated from a free-ranging rough-toothed dolphin Steno bredanensis (Cetacea: Delphinidae) stranded in KoreaFrontiers in Veterinary Science, vol. 9, pp. 774836-774836K Lee; Seon Young Park; Hwi Won Seo; Y Cho; S G Choi; S Seo; W Han; Nam-Kyung Lee; Hyemin Kwon; J E Han, et al.
Article
3 2022

2022Article

A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation modelScientific Reports, vol. 12, pp. 9611-9611N Ko; J Shim; H J Kim; Y Lee; J K Park; K Kwak; Jeong Woong Lee; D I Jin; H Kim; K Choi
Article
4 2022

2022Article

First report on Enterocytozoon hepatopenaei (EHP) infection in Pacific white shrimp (Penaeus vannamei) cultured in KoreaAquaculture, vol. 547, pp. 737525-737525Ji Hyung Kim; C Lee; H J Jeon; B K Kim; Nam-Kyung Lee; S K Choi; J E Han
Article
5 2022

2022Article

Isothermal amplification-mediated lateral flow biosensors for in vitro diagnosis of gastric cancer-related microRNAsTalanta, vol. 246, pp. 123502-123502Seung Beom Seo; Jin-Seong Hwang; E Kim; K Kim; S Roh; G Lee; Jaewoo Lim; Byunghoon Kang; Soojin Jang; Seong Uk Son, et al.
Article
6 2022

2022Article

Retinol binding protein 7 promotes adipogenesis in vitro and regulates expression of genes involved in retinol metabolismFrontiers in Cell and Developmental Biology, vol. 10, pp. 876031-876031Dong-Hwan Kim; J Ahn; Y Suh; O Ziouzenkova; Jeong Woong Lee; K Lee
Article
7 2022

2022Article

Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cellsBiomedicine & Pharmacotherapy, vol. 146, pp. 112500-112500Tae-Hee Han; Min Kyung Park; H Nakamura; Hyun Seung Ban
Article
8 2022

2022Article

Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancerISME Journal, vol. 16, no. 5, pp. 1205-1221Tae Young Ryu; Kwangho Kim; Tae-Su HanMi Ok Lee; Jinkwon Lee; Jinhyeon Choi; Kwang Bo Jung; Eun Jeong Jeong; Da Mi An; Cho-Rok Jung, et al.
Article
9 2022

2022Article

Janus hydrogel-based fuel stimulant powered amplification for multiple detections of miRNA biomarkers in gastric cancer = 위암 정밀 진단을 위한 유전자 마커 동반 검출 플랫폼 개발Chemical Engineering Journal, vol. 448, pp. 137637-137637Jaewoo Lim; Jin-Seong Hwang; Seung Beom Seo; Byunghoon Kang; Soojin Jang; Seong Uk Son; Jisun Ki; Jang Seong Kim; Taejoon KangJuyeon Jung, et al.
Article
10 2022

2022Article

Identification of a peptide ligand facilitating percutaneous delivery of macromolecular cargo via inner root sheath in hair follicles by phage display combined with quantitative real-time PCR as a validation toolJournal of Drug Delivery Science and Technology, vol. 67, pp. 102965-102965Nam-Kyung Lee; S H Oh; Y J Choi; S K Kang
Article
11 2022

2022Article

Monoclonal antibody K312-based depletion of pluripotent cells from differentiated stem cell progeny prevents teratoma formationBMB Reports, vol. 55, no. 3, pp. 142-147Jongjin Park; Dong Gwang Lee; Na Geum Lee; Min-Gi Kwon; Yeon Sung Son; Mi-Young SonKwang-Hee BaeJangwook LeeJong Gil ParkNam-Kyung Lee, et al.
Article
12 2022

2022Article

KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditureExperimental and Molecular Medicine, vol. 54, no. 8, pp. 1250-1261Ju Hong Jang; Jeong Woong Lee; Min Ji Cho; Byungtae Hwang; Min-Gi Kwon; Dong-Hwan Kim; Nam-Kyung LeeJangwook LeeYoung-Jun ParkYong Ryoul Yang, et al.
Article
13 2022

2022Article

A sensitive immunodetection assay using antibodies specific to staphylococcal enterotoxin B produced by baculovirus expressionBiosensors, vol. 12, no. 10, pp. 787-787Ju Hong Jang; Sungsik Kim; Seul Gi Kim; Jaemin Lee; Dong Gwang Lee; Jieun Jang; Y S Jeong; D H Song; Jeong Ki Min; Jong Gil Park, et al.
Article
14 2022

2022Article

Cancer-specific cytotoxicity of pyridinium-based ionic liquids by regulating hypoxia-inducible factor-1α-centric cancer metabolismEcotoxicology and Environmental Safety, vol. 248, pp. 114334-114334Tae Hee Han; J D Lee; B C Seo; W H Jeon; Hyun-Ah Yang; Seongyeong Kim; Keeok Haam; Min Kyung Park; Junhee Park; Tae-Su Han, et al.
Article
15 2021

2021Article

Amplification of EBNA-1 through a single-plasmid vector-based gene amplification system in HEK293 cells as an efficient transient gene expression systemApplied Microbiology and Biotechnology, vol. 105, no. 1, pp. 67-76Sun-Hye Park; Jong-Ho Park; Joo Hyoung Lee; Hoon Min Lee; Yeon Ju Kang; Eun Ji Lee; S Shin; G M Lee; Yeon-Gu Kim
Article
16 2021

2021Article

Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)Expert Opinion on Therapeutic Patents, vol. 31, no. 5, pp. 387-397Hyun Seung Ban; Y Uto; H Nakamura
Article
17 2021

2021Article

N-acetyl-L-cysteine improves the developmental competence of bovine oocytes and embryos cultured in vitro by attenuating oxidative damage and apoptosisAntioxidants, vol. 10, no. 6, pp. 860-860W S Sun; H Jang; M R Park; K B Oh; H Lee; S Hwang; L J Xu; I S Hwang; Jeong Woong Lee
Article
18 2021

2021Article

In vivo monitoring platform of transplanted human stem cells using magnetic resonance imagingBiosensors & Bioelectronics, vol. 178, pp. 113039-113039S Han; Byunghoon Kang; H Y Son; Y Choi; M K Shin; Jongjin Park; Jeong Ki Min; D Park; Eun Kyung Lim; Y M Huh, et al.
Article
19 2021

2021Article

Loss of desmoglein-2 promotes gallbladder carcinoma progression and resistance to EGFR-targeted therapy through Src kinase activationCell Death and Differentiation, vol. 28, no. 3, pp. 968-984Sang-Hyun Lee; J M Kim; Dong Gwang LeeJangwook LeeJong Gil ParkTae-Su HanHyun-Soo ChoYoung Lai ChoKwang-Hee BaeYoung-Jun Park, et al.
Article
20 2021

2021Article

Long-term depletion of Cereblon induces mitochondrial dysfunction in cancer cellsBMB Reports, vol. 54, no. 6, pp. 305-310Seulki Park; K Kim; Keeok Haam; Hyun Seung BanJung Ae KimByoung Chul ParkSung Goo Park; Sunhong Kim; Jeong Hoon Kim
Article
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