Biotherapeutics Translational Research Center (바이오신약중개연구센터)517

연구분야

  • 암/혈관신생/혈관염증 조절 표적 발굴 및 제어 기술 개발
    • 다기능 항체 라이브러리 시스템 기반 표적 발굴 및 항체 개발
    • 줄기세포 기반 혈관내피분화조절
  • 약제내성 및 암전이 조절 규명 및 제어 기술 개발
    • 기초-임상 중개연구를 통한 신약개발
  • 암 특이적 세포대사-신호를 표적으로 한 질환 치료제 개발 및 적용기술 개발연구
    • 암세포 대사체 젖산의 역할 및 작용기전 연구
    • 젖산 신호전달체계 조절을 통한 질환 치료기술 연구
  • 면역결핍돼지 생산에 관련한 유전자 발굴
    • 면역거부반응을 일으키는 인자에 대한 메커니즘 연구
  • 질환동물 생산 및 기능적 연구
    • Gene editing system을 이용한 유전자 결손 및 변이 동물 생산
    • 동물모델을 이용한 분자유전학적 및 생리학적 기능에 대한 연구
더보기

Showing results 1 to 20 of 252

No. Year Title Type
1 2023

2023Article

The EDN1/EDNRA/β-arrestin axis promotes colorectal cancer progression by regulating STAT3 phosphorylationInternational Journal of Oncology, vol. 62, pp. 13-13Yeo Jin Lee; Eunsun Jung; Jinhyeon Choi; Jinseong Hwang; Eun-Jeong Jeong; Yuna Roh; Hyun Seung Ban; Sunhong Kim; Seon-Kyu KimSeon-Young Kim, et al.
Article
2 2023

2023Article

Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in miceDiabetologia, vol. 66, no. 5, pp. 931-954Da Som Lee; Tae Hyeon An; Hyunmi Kim; Eunsun Jung; G Kim; S Y Oh; J S Kim; H J Chun; Jaeeun JungEun-Woo Lee, et al.
Article
3 2023

2023Article

Hemicyanine-based near-infrared fluorescence off-on probes for imaging intracellular and in vivo nitroreductase activityInternational Journal of Molecular Sciences, vol. 24, no. 7, pp. 6074-6074Sun Hyeok Lee; Chul Soon Park; Kyung Kwan Lee; Tae Hee Han; Hyun Seung BanChang-Soo Lee
Article
4 2023

2023Article

Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivationCardiovascular Research, vol. 119, no. 5, pp. 1265-1278Min Ji ChoDong Gwang LeeJeong Woong Lee; Byungtae Hwang; Sung Jin YoonSeon-Jin LeeYoung-Jun Park; Seung-Ho Park; Hee Gu LeeYong-Hoon Kim, et al.
Article
5 2023

2023Article

Hepatic PTP4A1 ameliorates high-fat diet-induced hepatosteatosis and hyperglycemia by the activation of the CREBH/FGF21 axisTheranostics, vol. 13, no. 3, pp. 1076-1090Byungtae Hwang; Min-Gi Kwon; Min Ji ChoNam-Kyung LeeJangwook LeeJeong Woong LeeKyoung-Jin OhKwang-Hee BaeJung Hwan Hwang; Jeong Ki Min, et al.
Article
6 2023

2023Article

Intracellular glucose-depriving polymer micelles for anti-glycolytic cancer treatmentAdvanced Materials, vol. 35, no. 10, pp. 2207342-2207342Jangwook Lee; K Kim; I C Kwon; K Y Lee
Article
7 2023

2023Article

Kaempferol alleviates mitochondrial damage by reducing mitochondrial reactive oxygen species production in lipopolysaccharide-induced prostate organoidsFoods, vol. 12, no. 20, pp. 3836-3836M J Lee; Y Cho; Y Hwang; Y Jo; Yeon-Gu Kim; S H Lee; J H Lee
Article
8 2023

2023Article

The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolismNature Communications, vol. 14, pp. 5728-5728Mihee Oh; S Y Jang; Ji Yoon Lee; Jong Woo Kim; Y Jung; J Kim; Jinho SeoTae-Su Han; E Jang; H Y Son, et al.
Article
9 2023

2023Article

A critical role for ERO1α in arterial thrombosis and ischemic strokeCirculation Research, vol. 132, no. 11, pp. e206-e222V Jha; B Xiong; T Kumari; G Brown; J Wang; K Kim; J Lee; N Asquith; J Gallagher; L Asherman, et al.
Article
10 2023

2023Article

Design, synthesis and biological evaluation of novel MDH inhibitors targeting tumor microenvironmentPharmaceuticals, vol. 16, no. 5, pp. 683-683S Godesi; Jeong-Ran Han; Jang Keun Kim; D I Kwak; J Lee; H Nada; M Kim; Hyun A Yang; Joo-Young ImHyun Seung Ban, et al.
Article
11 2023

2023Article

FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent mannerCell Death & Disease, vol. 14, no. 8, pp. 567-567Jong Woo Kim; M J Kim; Tae Hee Han; Ji Yoon Lee; Sangok KimHyerin KimKyoung-Jin OhWon Kon KimBaek Soo HanKwang-Hee Bae, et al.
Article
12 2023

2023Article

Streamlined in vitro screening system of synthetic signal peptides in Chinese hamster ovary cells for therapeutic protein productionJournal of Biotechnology, vol. 375, pp. 12-16Jong-ho Park; Na-Yeong Heo; Hoon Min Lee; Eun Ji Lee; Soomin Park; G M Lee; Yeon-Gu Kim
Article
13 2023

2023Article

Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasisExperimental and Molecular Medicine, vol. 55, no. 5, pp. 952-964Kwangho Kim; Tae Young Ryu; Eunsun Jung; Tae-Su Han; Jinkwon Lee; Seon-Kyu Kim; Yu Na Roh; Moo-Seung LeeCho-Rok JungJung Hwa Lim, et al.
Article
14 2023

2023Article

TGF-β and SHH regulate pluripotent stem cell differentiation into brain microvascular endothelial cells in generating an in vitro blood?brain barrier modelBioengineering, vol. 10, no. 10, pp. 1132-1132Na Geum Lee; Mi-Hee Lim; Jongjin Park; I C Jeung; Byungtae Hwang; Jangwook LeeJong Gil ParkMi-Young SonBaek Soo HanSung Jin Yoon, et al.
Article
15 2023

2023Article

Novel sandwich immunoassay detects a shrimp AHPND-causing binary PirABVp toxin produced by Vibrio parahaemolyticusFrontiers in Cellular and Infection Microbiology, vol. 13, pp. 1294801-1294801Min Young Jeon; J E Han; Dong Gwang LeeYoung Lai Cho; Ju-Hong Jang; Jangwook LeeJong Gil Park; Do Hyung Kwon; S Y Park; W Kim, et al.
Article
16 2022

2022Article

A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation modelScientific Reports, vol. 12, pp. 9611-9611N Ko; J Shim; H J Kim; Y Lee; J K Park; K Kwak; Jeong Woong Lee; D I Jin; H Kim; K Choi
Article
17 2022

2022Article

First report on Enterocytozoon hepatopenaei (EHP) infection in Pacific white shrimp (Penaeus vannamei) cultured in KoreaAquaculture, vol. 547, pp. 737525-737525Ji Hyung Kim; C Lee; H J Jeon; B K Kim; Nam-Kyung Lee; S K Choi; J E Han
Article
18 2022

2022Article

Isothermal amplification-mediated lateral flow biosensors for in vitro diagnosis of gastric cancer-related microRNAsTalanta, vol. 246, pp. 123502-123502Seung Beom Seo; Jin-Seong Hwang; E Kim; K Kim; S Roh; G Lee; Jaewoo Lim; Byunghoon Kang; Soojin Jang; Seong Uk Son, et al.
Article
19 2022

2022Article

Retinol binding protein 7 promotes adipogenesis in vitro and regulates expression of genes involved in retinol metabolismFrontiers in Cell and Developmental Biology, vol. 10, pp. 876031-876031Dong-Hwan Kim; J Ahn; Y Suh; O Ziouzenkova; Jeong Woong Lee; K Lee
Article
20 2022

2022Article

Pathological and genomic findings of Erysipelothrix rhusiopathiae isolated from a free-ranging rough-toothed dolphin Steno bredanensis (Cetacea: Delphinidae) stranded in KoreaFrontiers in Veterinary Science, vol. 9, pp. 774836-774836K Lee; Seon Young Park; Hwi Won Seo; Y Cho; S G Choi; S Seo; W Han; Nam-Kyung Lee; Hyemin Kwon; J E Han, et al.
Article
1 2 3 4 5 6 7 8 9 10 11 13