Biotherapeutics Translational Research Center (바이오신약중개연구센터)264

연구분야

  • 암/혈관신생/혈관염증 조절 표적 발굴 및 제어 기술 개발
    • 다기능 항체 라이브러리 시스템 기반 표적 발굴 및 항체 개발
    • 줄기세포 기반 혈관내피분화조절
  • 약제내성 및 암전이 조절 규명 및 제어 기술 개발
    • 기초-임상 중개연구를 통한 신약개발
  • 암 특이적 세포대사-신호를 표적으로 한 질환 치료제 개발 및 적용기술 개발연구
    • 암세포 대사체 젖산의 역할 및 작용기전 연구
    • 젖산 신호전달체계 조절을 통한 질환 치료기술 연구
  • 면역결핍돼지 생산에 관련한 유전자 발굴
    • 면역거부반응을 일으키는 인자에 대한 메커니즘 연구
  • 질환동물 생산 및 기능적 연구
    • Gene editing system을 이용한 유전자 결손 및 변이 동물 생산
    • 동물모델을 이용한 분자유전학적 및 생리학적 기능에 대한 연구
더보기

Showing results 1 to 20 of 212

No. Year Title Type
1 2021

2021Article

Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cellsBiomedicine & Pharmacotherapy, vol. 133, pp. 111082-111082Min Kyung Park; Z Ji; Keeok Haam; Tae Hee Han; Seona Lim; Mi-Jung Kang; S S Lim; Hyun Seung Ban
Article
2 2021

2021Article

MicroRNA-based therapeutics for drug-rsistant colorectal cancerPharmaceuticals, vol. 14, no. 2, pp. 136-136Eunsun Jung; Jinhyeon Choi; Jang Seong Kim; Tae-Su Han
Article
3 2021

2021Article

In vivo monitoring platform of transplanted human stem cells using magnetic resonance imagingBiosensors & Bioelectronics, vol. 178, pp. 113039-113039S Han; Byunghoon Kang; H Y Son; Y Choi; M K Shin; Jongjin Park; Jeong Ki Min; D Park; Eun Kyung Lim; Y M Huh, et al.
Article
4 2021

2021Article

Amplification of EBNA-1 through a single-plasmid vector-based gene amplification system in HEK293 cells as an efficient transient gene expression systemApplied Microbiology and Biotechnology, vol. 105, no. 1, pp. 67-76Sun-Hye Park; Jong-Ho Park; Joo Hyoung Lee; Hoon Min Lee; Yeon Ju Kang; Eun Ji Lee; S Shin; G M Lee; Yeon-Gu Kim
Article
5 2021

2021Article

Effect of sex-specific differences on function of induced hepatocyte-like cells generated from male and female mouse embryonic fibroblastsStem Cell Research & Therapy, vol. 12, no. 1, pp. 79-79I Ullah; Y Shin; Y Kim; K B Oh; S Hwang; Y I Kim; Jeong Woong Lee; T Y Hur; S Lee; S A Ock
Article
6 2021

2021Article

Loss of desmoglein-2 promotes gallbladder carcinoma progression and resistance to EGFR-targeted therapy through Src kinase activationCell Death and Differentiation, vol. 20, pp. 628-4Sang-Hyun Lee; J M Kim; Dong Gwang LeeJangwook LeeJong Gil ParkTae-Su HanHyun-Soo ChoYoung Lai ChoKwang-Hee BaeYoung-Jun Park, et al.
Article
7 2021

2021Article

The development of a functional human small intestinal epithelium model for drug absorptionScience Advances, vol. 7, no. 23, pp. eabh1586-eabh1586Ohman Kwon; Kwang Bo Jung; Kyeong-Ryoon Lee; Ye Seul Son; Hana Lee; Jongjin Kim; Kwangho Kim; Seop Lee; Yoo-Kyung Song; Jaeeun Jung, et al.
Article
8 2021

2021Article

N-acetyl-L-cysteine improves the developmental competence of bovine oocytes and embryos cultured in vitro by attenuating oxidative damage and apoptosisAntioxidants, vol. 10, no. 6, pp. 860-860W S Sun; H Jang; M R Park; K B Oh; H Lee; S Hwang; L J Xu; I S Hwang; Jeong Woong Lee
Article
9 2021

2021Article

Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020)Expert Opinion on Therapeutic Patents, vol. 31, no. 5, pp. 387-397Hyun Seung Ban; Y Uto; H Nakamura
Article
10 2021

2021Article

V-set and immunoglobulin domain-containing 1 (Vsig1), predominantly expressed in testicular germ cells, is dispensable for spermatogenesis and male fertility in miceAnimals, vol. 11, no. 4, pp. 1037-1037Yena Jeong; H Bang; Young Hyun Kim; N E Park; Young-Ho Park; C Park; S R Lee; Jeong Woong LeeBong-Seok SongJi-Su Kim, et al.
Article
11 2020

2020Article

Ischemia-induced Netrin-4 promotes neovascularization through endothelial progenitor cell activation via Unc-5 Netrin receptor BFASEB Journal, vol. 34, no. 1, pp. 1231-1246Na Geum Lee; I C Jeung; S C Heo; Jinhoi Song; Wooil Kim; Byungtae Hwang; Min-Gi Kwon; Yeon-Gu KimJangwook LeeJong Gil Park, et al.
Article
12 2020

2020Article

Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancerBiochemical and Biophysical Research Communications, vol. 523, no. 3, pp. 726-732Hwee Jin Kim; Hyun Soo ChoHyun Seung Ban; H Nakamura
Article
13 2020

2020Article

High-performance conducting polymer nanotube-based liquid-ion gated field-effect transistor aptasensor for dopamine exocytosisScientific Reports, vol. 10, pp. 3772-3772Seon Joo Park; Jiyeon Lee; Sung Eun Seo; Kyung Ho Kim; Chul Soon Park; S H Lee; Hyun Seung Ban; B D Lee; H S Song; Jinyeong Kim, et al.
Article
14 2020

2020Article

Dsg2-mediated c-Met activation in anaplastic thyroid cancer motility and invasionEndocrine-Related Cancer, vol. 27, no. 11, pp. 601-614Kungmin Lee; Sang Hyun Lee; Wooil Kim; Jangwook LeeJong Gil Park; Jang Seong Kim; J T Kim; Y E Kang; M Shong; H J Lee, et al.
Article
15 2020

2020Article

Protein disulfide isomerase in cardiovascular diseaseExperimental and Molecular Medicine, vol. 52, no. 3, pp. 390-399B Xiong; V Jha; Jeong Ki Min; J Cho
Article
16 2020

2020Article

IDH1-dependent α-KG regulates brown fat differentiation and function by modulating histone methylationMetabolism-Clinical and Experimental, vol. 105, pp. 154173-154173Hyun Sup Kang; Jae Ho Lee; Kyoung-Jin OhEun-Woo LeeBaek Soo Han; K Y Park; J M Suh; Jeong Ki MinSeung-Wook ChiSang Chul Lee, et al.
Article
17 2020

2020Article

Effects of Leucosporidium-derived ice-binding protein (LeIBP) on bull semen cryopreservationVeterinary Medicine and Science, vol. 6, pp. 447-453Hoon Jang; Hyo-Jin Kwon; W S Sun; S Hwang; I S Hwang; S Kim; J H Lee; S G Lee; Jeong Woong Lee
Article
18 2020

2020Article

Developmental and degenerative characterization of porcine parthenogenetic fetuses during early pregnancyAnimals, vol. 10, no. 4, pp. 622-622I S Hwang; M R Park; H S Lee; T U Kwak; H Y Son; J K Kang; Jeong Woong Lee; K Lee; E W Park; S Hwang
Article
19 2020

2020Article

Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathwaysTheranostics, vol. 10, no. 11, pp. 5048-5063Hana Lee; Ye Seul Son; Mi Ok Lee; Jea Woon Ryu; Kunhyang Park; Ohman Kwon; Kwang Bo Jung; Kwangho Kim; Tae Young Ryu; Areum Baek, et al.
Article
20 2020

2020Article

Intestinal morphogenesis in development, regeneration, and disease: the potential utility of intestinal organoids for studying compartmentalization of the crypt-villus structureFrontiers in Cell and Developmental Biology, vol. 8, pp. 593969-593969Ohman Kwon; Tae Su HanMi Young Son
Article
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