Immunotherapy Research Center (면역치료제연구센터)810

연구분야

  • HSC 기반 유전자 NK세포치료제 개발 (PL1,2)
    • 융복합 NK세포치료 임상연구
    • CAR-NK 세포 치료제 개발
    • 단일세포 영상 기반 면역세포 효능 검증
    • 주입형 나노하이드로겔 복합체 기반 면역세포 3차원 배양기술 개발
  • 항암제 활용 맞춤형 혼합 NK세포치료제 개발 (PL3)
    • 암세포에 있어서 NK 세포의 공격에 대한 감수성을 높이는 항암제 개발
    • 줄기세포 유래 NK 세포 항암기능향상 항암제 개발
    • 간암 맞춤형 전임상을 통한 NK 세포 치료제와의 혼합치료 최적화 기술 개발
  • 생체 이미징을 이용한 전임상 동물모델에서의 면역세포치료 효능 검증
    • 이식된 세포에 대한 동물모델에서의 실시간 생체영상 추적으로 NK 세포치료 유효성 검증
    • 생체영상 치료효과 모니터링을 통한 NK, NK-항암제, NK-항체 치료에 대한 치료 유효성 검증
더보기

Showing results 1 to 20 of 524

No. Year Title Type
1 2022

2022Article

PLAG alleviates cisplatin-induced cachexia in lung cancer implanted miceTranslational Oncology, vol. 20, pp. 101398-101398G T Kim; E Y Kim; S H Shin; H Lee; S H Lee; K Park; K Y Sohn; S Y Yoon; Jae Wha Kim
Article
2 2022

2022Article

SARS-CoV-2 peptides bind to NKG2D and increase NK cell activityCellular Immunology, vol. 371, pp. 104454-104454Hanna Kim; Byun Jae Eun; Suk Ran Yoon; H Koohy; Haiyoung Jung; In Pyo Choi
Article
3 2022

2022Article

Suppression of tumor progression by thioredoxin-interacting protein-dependent adenosine 2B receptor degradation in a PLAG-treated Lewis lung carcinoma-1 model of non-small cell lung cancerNeoplasia, vol. 31, pp. 100815-100815G T Kim; E Y Kim; SH Shin; H Lee; S H Lee; K Y Sohn; Jae Wha Kim
Article
4 2022

2022Article

Ginsenoside 20(R)-Rg3 enhances natural killer cell activity by increasing activating receptor expression through the MAPK/ERK signaling pathwayInternational Immunopharmacology, vol. 107, pp. 108618-108618Yunhee Lee; Arum Park; Young-Jun ParkHaiyoung JungTae-Don KimJi Yoon Noh; In Pyo Choi; S Lee; Suk Ran Yoon
Article
5 2022

2022Article

PLAG co-treatment increases the anticancer effect of Adriamycin and cyclophosphamide in a triple-negative breast cancer xenograft mouse modelBiochemical and Biophysical Research Communications, vol. 619, pp. 110-116G T Kim; S H Shin; EE Y Kim; H Lee; S H Lee; K Y Sohn; Jae Wha Kim
Article
6 2022

2022Article

Improving anticancer effect of aPD-L1 through lowering neutrophil infiltration by PLAG in tumor implanted with MB49 mouse urothelial carcinomaBMC Cancer, vol. 22, pp. 727-727G T Kim; E Y Kim; S H Shin; H Lee; S H Lee; K Y Sohn; Jae Wha Kim
Article
7 2022

2022Article

Aurantii Fructus Immaturus enhances natural killer cytolytic activity and anticancer efficacy in vitro and in vivoFrontiers in Medicine, vol. 9, pp. 973681-973681Arum Park; Yunjeong Yang; Yunhee Lee; Haiyoung JungTae-Don KimJi Yoon Noh; S Lee; Suk Ran Yoon
Article
8 2022

2022Article

Ponciri Fructus Immaturus ethanol extract attenuates septic shock through inhibition of the STAT1 signaling pathwayFrontiers in Nutrition, vol. 9, pp. 988309-988309Yo Sep Hwang; Jun-Pil Jang; S H Park; A Kim; Jae-Hyuk JangHyang Ran YoonSuk Ran Yoon; J H Park; Hee Jun ChoHee Gu Lee
Article
9 2022

2022Article

miR-302 suppresses the proliferation, migration, and invasion of breast cancer cells by downregulating ATAD2Cancers, vol. 14, no. 18, pp. 4345-4345Yo Sep Hwang; Eun Sun Park; Byung Moo Oh; T G Uhm; Suk Ran YoonJong Lyul ParkHee Jun ChoHee Gu Lee
Article
10 2022

2022Article

The role of IL-7 and IL-7R in cancer pathophysiology and immunotherapyInternational Journal of Molecular Sciences, vol. 23, no. 18, pp. 10412-10412Chunli Wang; Lingzu Kong; Seokmin Kim; Sunyoung Lee; Sechan Oh; Seona Cho; Inhwan Jang; Tae-Don Kim
Article
11 2022

2022Article

Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistanceiScience, vol. 25, no. 9, pp. 105017-105017Y J Choe; J Y Min; H Lee; S Y Lee; J Kwon; H J Kim; J Lee; H M Kim; H S Park; M Y Cho, et al.
Article
12 2022

2022Article

A double-edged sword: the two faces of PARylationInternational Journal of Molecular Sciences, vol. 23, no. 17, pp. 9826-9826M Kang; S Park; S H Park; Hee Gu Lee; J H Park
Article
13 2021

2021Article

Exploration of alternative splicing events in mesenchymal stem cells from human induced pluripotent stem cellsGenes, vol. 12, no. 5, pp. 737-737Ji Eun Jeong; Binna SeolHan-Seop Kim; Jae Yun Kim; Yee Sook Cho
Article
14 2021

2021Article

Collapsin response mediator protein 4 enhances the radiosensitivity of colon cancer cells through calcium-mediated cell signalingOncology Reports, vol. 45, no. 4, pp. 6-6Sang Yoon Park; Jong-Tae Kim; Eun Sun Park; Yo Sep Hwang; Hyang Ran Yoon; Kyung Eun Baek; Haiyoung JungSuk Ran YoonBo Yeon KimHee Jun Cho, et al.
Article
15 2021

2021Article

Mitigation of hematopoietic syndrome of acute radiation syndrome by 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) is associated with regulation of systemic inflammation in a murine model of total-body irradiationRadiation Research, vol. 196, no. 1, pp. 55-65Y J Kim; J Jeong; K Park; K Y Sohn; S Y Yoon; Jae Wha Kim
Article
16 2021

2021Article

The human TOR signaling regulator is the key indicator of liver cancer patients' overall survival: TIPRL/LC3/CD133/CD44 as potential biomarkers for early liver cancersCancers, vol. 13, no. 12, pp. 2925-2925Soo Young Jun; Hyang Ran YoonJi Yong Yoon; Su Jin Jeon; Jeong Ju Lee; D Halder; J M Kim; Nam-Soon Kim
Article
17 2021

2021Article

Tryptophanyl-tRNA synthetase as a potential therapeutic targetInternational Journal of Molecular Sciences, vol. 22, no. 9, pp. 4523-4523Young Ha Ahn; Se-Chan Oh; S Zhou; Tae-Don Kim
Article
18 2021

2021Article

TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasisScience Signaling, vol. 14, no. 688, pp. eabe6156-eabe6156M L Uribe; M Dahlhoff; R N Batra; N B Nataraj; Y Haga; D Drago-Garcia; I Marrocco; A Sekar; S Ghosh; I Vaknin, et al.
Article
19 2021

2021Article

Modeling sialidosis with neural precursor cells derived from patient-derived induced pluripotent stem cellsInternational Journal of Molecular Sciences, vol. 22, no. 9, pp. 4386-4386Binna Seol; Young-Dae Kim; Yee Sook Cho
Article
20 2021

2021Article

Transforming growth factor β inhibits MUC5AC expression by Smad3/HDAC2 complex formation and NF-κB deacetylation at K310 in NCI-H292 cellsMolecules and Cells, vol. 44, no. 1, pp. 38-49Su Ui LeeMun-Ock Kim; Myung Ji Kang; Eun Sol Oh; H Ro; Ro-Woon Lee; Yu Na Song; Sunin Jung; Jae-Won LeeSoo Yun Lee, et al.
Article
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