Disease Target Structure Research Center (질환표적구조연구센터)636

연구분야

  • 질환표적 단백질의 구조 및 기능에 관한 연구
    • X-선 결정학(X-ray crystallography) 및 핵자기공명학(NMR spectroscopy)을 이용한 세포사멸, 세포분열, 암세포 생성 등 세포신호전달 조절 단백질들의 삼차구조 및 작용기작 규명
    • 질환표적 제어를 위한 구조 기반 약물 개발
  • 단백체학 기반 질환표적 단백질 발굴 및 검증
    • 단백체학 기반 세포사멸 interactome 분석
    • 아토피성 피부염, 천식, 류마티스성 관절염 등 면역질환 생체지표의 발굴 및 기능성 검증
  • 동물모델 기반 퇴행성질환 제어 연구
    • 맞춤형 다중 퇴행성뇌질환 표현형 동물모델 (초파리 및 제브라피쉬) 평가 플랫폼 확립
    • 퇴행성뇌질환 동물모델 기반 신규 후보물질 및 바이오마커 기작 연구
  • 세포신호전달 연구를 통한 신약개발
    • GPCR, Wnt, mTOR 등 다양한 세포신호전달 기전 연구
    • 다양한 활성평가법을 이용한 유효물질 발굴 및 선도물질 도출
  • 나노포어 (Nanopore) 기반 단백질 및 RNA 센싱 연구
    • 나노포어를 이용한 약물 스크리닝 기술 개발
더보기

Showing results 181 to 200 of 415

No. Year Title Type
181 2016

2016Article

Structural study of the HD-PTP Bro1 domain in a complex with the core region of STAM2, a subunit of ESCRT-0PLoS One, vol. 11, no. 2, pp. e0149113-e0149113Juhyun Lee; Kyoung Jin Oh; Dasom Lee; Bo Yeon Kim; J S Choi; Bonsu KuSeung Jun Kim
Article
182 2016

2016Article

Kahweol induces apoptosis by suppressing BTF3 expression through the ERK signaling pathway in non-small cell lung cancer cellsInternational Journal of Oncology, vol. 49, no. 6, pp. 2294-2302Young Joo Jeon; W Bang; J H Cho; R H Lee; Seok Ho Kim; M S Kim; S M Park; J C Shin; H J Chung; K B Oh, et al.
Article
183 2016

2016Article

Kinetics for zinc ion induced sepia pharaonis arginine kinase inactivation and aggregationProtein and Peptide Letters, vol. 23, no. 6, pp. 508-517Y X Si; Jinhyuk Lee; J G Cheng; S J Yin; Y D Park; G Y Qian; X M Jiang
Article
184 2016

2016Article

Anti-obesity effects of spiramycin in vitro and in vivoPLoS One, vol. 11, no. 7, pp. e0158632-e0158632Mun-Ock KimHyung Won Ryu; Ji Hee Choi; Tae Hyun Son; Sei-Ryang Oh; Hyun Sun Lee; Heung Joo Yuk; Sungchan ChoJong Soon KangChang Woo Lee, et al.
Article
185 2016

2016Article

Mitochondrial Akt regulation of hypoxic tumor reprogrammingCancer Cell, vol. 30, no. 2, pp. 257-272Y C Chae; V Vaira; M C Caino; H Y Tang; J H Seo; A V Kossenkov; L Ottobrini; C Martelli; G Lucignani; I Bertolini, et al.
Article
186 2016

2016Article

Scaffold role of DUSP22 in ASK1-MKK7-JNK signaling pathwayPLoS One, vol. 11, no. 10, pp. e0164259-e0164259A Ju; Y C Cho; B R Kim; Sung Goo ParkJeong Hoon Kim; K Kim; J Lee; Byoung Chul Park; S Cho
Article
187 2016

2016Article

Crystal structure of SP-PTP, a low molecular weight protein tyrosine phosphatase from Streptococcus pyogenesBiochemical and Biophysical Research Communications, vol. 478, no. 3, pp. 1217-1222Bonsu Ku; Chae Won Keum; Hye Seon Lee; Hye Yeoung Yun; Ho Chul ShinBo Yeon KimSeung Jun Kim
Article
188 2016

2016Article

High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-BasBiochemical and Biophysical Research Communications, vol. 478, pp. 1205-1210Sang-Ok Lee; Mi-Kyung LeeBonsu KuKwang-Hee Bae; Sang Chul Lee; H M Lim; Seung Jun KimSeung-Wook Chi
Article
189 2016

2016Article

Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cellsBMB Reports, vol. 49, no. 10, pp. 560-565Phil Young Lee; Byoung Chul ParkSeung-Wook ChiKwang-Hee Bae; Sunhong Kim; S Cho; S Kang; Jeong Hoon KimSung Goo Park
Article
190 2016

2016Article

cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis = 가족성 근위축성 측삭경화증 연관 돌연변이 SOD1 단백질의 cIAP에 의한 분해Biochemical and Biophysical Research Communications, vol. 480, no. 3, pp. 422-428Jin Sun Choi; Kidae Kim; D H Lee; S Cho; J D Ha; Byoung Chul Park; Sunhong Kim; Sung Goo ParkJeong Hoon Kim
Article
191 2016

2016Article

Discovery of novel striatal-enriched protein tyrosine phosphatase inhibitors through structure-based virtual screeningBulletin of Korean Chemical Society, vol. 37, no. 11, pp. 1783-1788Bonsu Ku; Jin A You; Hye Seon Lee; Ho Chul Shin; H Park; Seung Jun Kim
Article
192 2016

2016Article

Structural features of Cas2 from Thermococcus onnurineus in CRISPR-cas system type IVProtein Science, vol. 25, pp. 1890-1897Tae-Yang Jung; Kwang Hyun Park; Yan An; A Schulga; S Deyev; J H Jung; Eui-jeon Woo
Article
193 2016

2016Article

Clinical relevance and molecular phenotypes in gastric cancer, of TP53 mutations and gene expressions, in combination with other gene mutationsScientific Reports, vol. 6, pp. 34822-34822S Park; Jinhyuk Lee; Y H Kim; J Park; S W Shin; S Nam
Article
194 2016

2016Article

The identification of biochanin a as a potent and selective β-site app-cleaving enzyme 1 (Bace1) inhibitorNutrients, vol. 8, no. 10, pp. 637-637K Youn; J H Park; Jinhyuk Lee; W S Jeong; C T Ho; M Jun
Article
195 2016

2016Article

Effects of cadmium on the cuttlefish Sepia pharaonis' arginine kinase: unfolding kinetics integrated with computational simulationsJournal of Biomolecular Structure & Dynamics, vol. 34, no. 8, pp. 1763-1777Y X Si; Jinhyuk Lee; F Zhao; S J Yin; Y D Park; G Y Qian; X M Jiang
Article
196 2016

2016Article

Effect of cadmium ion on alpha-glucosidase: an inhibition kinetics and molecular dynamics simulation integration studyProtein Journal, vol. 35, no. 3, pp. 218-224T Luo; Jinhyuk Lee; Z R Lu; H Mu; L M Yue; Y D Park; Z M Ye
Article
197 2016

2016Article

A computational integrating kinetic study on the flexible active site of human acetaldehyde dehydrogenase 1Process Biochemistry, vol. 51, no. 6, pp. 725-733Y Xu; Jinhyuk Lee; H S Yang; Z R Lu; H Mu; J M Yang; Q Zhang; Y D Park
Article
198 2016

2016Article

Integration of inhibition kinetics and molecular dynamics simulations: a urea-mediated folding study on acetaldehyde dehydrogenase 1Applied Biochemistry and Biotechnology, vol. 179, no. 6, pp. 1101-1114Y Xu; Jinhyuk Lee; Z R Lu; H Mu; Q Zhang; Y D Park
Article
199 2016

2016Article

Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancerOncotarget, vol. 7, no. 49, pp. 81435-81451H R Chang; S Nam; Jinhyuk Lee; J H Kim; H R Jung; H S Park; S Park; Y Z Ahn; I Huh; C Balch, et al.
Article
200 2016

2016Article

Identification of a highly conserved hypothetical protein TON_0340 as a probable manganese-dependent phosphatasePLoS One, vol. 11, no. 12, pp. e0167549-e0167549Y S Sohn; S G Lee; K H Lee; Bonsu KuHo Chul Shin; S S Cha; Y G Kim; H S Lee; S G Kang; B H Oh
Article
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