Disease Target Structure Research Center (질환표적구조연구센터)636

연구분야

  • 질환표적 단백질의 구조 및 기능에 관한 연구
    • X-선 결정학(X-ray crystallography) 및 핵자기공명학(NMR spectroscopy)을 이용한 세포사멸, 세포분열, 암세포 생성 등 세포신호전달 조절 단백질들의 삼차구조 및 작용기작 규명
    • 질환표적 제어를 위한 구조 기반 약물 개발
  • 단백체학 기반 질환표적 단백질 발굴 및 검증
    • 단백체학 기반 세포사멸 interactome 분석
    • 아토피성 피부염, 천식, 류마티스성 관절염 등 면역질환 생체지표의 발굴 및 기능성 검증
  • 동물모델 기반 퇴행성질환 제어 연구
    • 맞춤형 다중 퇴행성뇌질환 표현형 동물모델 (초파리 및 제브라피쉬) 평가 플랫폼 확립
    • 퇴행성뇌질환 동물모델 기반 신규 후보물질 및 바이오마커 기작 연구
  • 세포신호전달 연구를 통한 신약개발
    • GPCR, Wnt, mTOR 등 다양한 세포신호전달 기전 연구
    • 다양한 활성평가법을 이용한 유효물질 발굴 및 선도물질 도출
  • 나노포어 (Nanopore) 기반 단백질 및 RNA 센싱 연구
    • 나노포어를 이용한 약물 스크리닝 기술 개발
더보기

Showing results 21 to 40 of 415

No. Year Title Type
21 2023

2023Article

Efficient valorization of food waste oils to renewable biodiesel by a Candida antarctica lipase B mutant that catalyzes the ester synthesis reaction in the presence of waterJournal of Cleaner Production, vol. 428, pp. 139336-139336Hyun Jun Ko; Mi-Jin Kim; H J Kim; Jin Kang; Ho-Yeon Lee; Jinhyuk LeeJung Hoon BaeBong Hyun SungJung Hoon Sohn
Article
22 2023

2023Article

Improving geometric validation metrics and ensuring consistency with experimental data through TrioSA: an NMR re?nement protocol = 실험 데이터와 일관성을 보장하고 TrioSA를 통한 NMR 정제 프로토콜을 통해 기하학적 검증 지표를 개선하는 방법International Journal of Molecular Sciences, vol. 24, no. 17, pp. 13337-13337Youngbeom Cho; Hyojung Ryu; Gyutae Lim; S Nam; Jinhyuk Lee
Article
23 2023

2023Article

Characterization and activity-folding relationship of serine protease from Antarctic krill (Euphausia superba)Journal of Biomolecular Structure & Dynamics, vol. 41, no. 11, pp. 5138-5151S J Yin; Ho-Yeon Lee; W Wang; Jinhyuk Lee; Y D Park
Article
24 2023

2023Article

Potent inhibition of human tyrosinase inhibitor by verproside from the whole plant of Pseudolysimachion rotundum var. subintegrumJournal of Enzyme Inhibition and Medicinal Chemistry, vol. 38, pp. 2252198-2252198Sunin Jung; So Yeun Woo; Mi Hyeon Park; Doo-Young KimSu Ui LeeSei-Ryang OhMun-Ock KimJinhyuk LeeHyung Won Ryu
Article
25 2023

2023Article

Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cellsCommunications Biology, vol. 6, pp. 712-712J I Ahn; L Zhang; H Ravishankar; L Fan; K Kirsch; Y Zeng; L Meng; J E Park; Hyeyoung Yoon; R Ghirlando, et al.
Article
26 2023

2023Article

Identification of two novel autism genes, TRPC4 and SCFD2, in Qatar simplex families through exome sequencingFrontiers in Psychiatry, vol. 14, pp. 1251884-1251884V Gupta; A Ben-Mahmoud; Bonsu Ku; D Velayutham; Z Jan; A Y Aden; A Kubbar; F Alshaban; L W Stanton; P V Jithesh, et al.
Article
27 2023

2023Article

Insights into the recognition mechanism in the UBR box of UBR4 for its specific substratesCommunications Biology, vol. 6, pp. 1214-1214Da Eun Jeong; Hye Seon Lee; Bonsu Ku; C H Kim; Seung Jun KimHo Chul Shin
Article
28 2023

2023Article

ANCA: artificial nucleic acid circuit with argonaute protein for one-step isothermal detection of antibiotic-resistant bacteriaNature Communications, vol. 14, pp. 8033-8033Hyowon Jang; Jayeon Song; S Kim; J H Byun; K G Lee; Kwang Hyun ParkEuijeon WooEun Kyung LimJuyeon JungTaejoon Kang
Article
29 2023

2023Article

Enhancing the thermostability and activity of glycosyltransferase UGT76G1 via computational designCommunications Chemistry, vol. 6, pp. 265-265Seong-Ryeong Go; Su-Jin Lee; Woo-Chan Ahn; Kwang Hyun ParkEuijeon Woo
Article
30 2023

2023Article

Shear stress induces monocyte/macrophage-mediated inflammation by upregulating cell-surface expression of heat shock proteinsBiomedicine & Pharmacotherapy, vol. 161, pp. 114566-114566H Son; H S Choi; S E Baek; Y H Kim; J Hur; J H Han; Jeong Hee Moon; Ga Seul Lee; Sung Goo Park; C H Woo, et al.
Article
31 2023

2023Article

Neuroprotective effects of licochalcone D in oxidative-stress-induced primitive neural stem cells from Parkinson's disease patient-derived iPSCsBiomedicines, vol. 11, no. 1, pp. 228-228Minyoung Oh; Juhyeon Nam; Areum Baek; J H Seo; J I Chae; S Y Lee; S K Chung; Byoung Chul ParkSung Goo ParkJanghwan Kim, et al.
Article
32 2022

2022Article

Marine invertebrate sialyltransferase of the sea squirt Ciona savignyi sialylated core 1 O-linked glycansInternational Journal of Biological Macromolecules, vol. 194, pp. 366-376Seonghun KimJinhyuk LeeDoo-Byoung OhOhsuk Kwon
Article
33 2022

2022Article

Novel GPR43 agonists exert an anti-Inflammatory effect in a colitis modelBiomolecules & Therapeutics, vol. 30, no. 1, pp. 48-54Bioh Park; Jong Soon Kang; S Paudel; Sung Goo ParkByoung Chul Park; S B Han; Y S Kwak; Jeong Hoon Kim; Sunhong Kim
Article
34 2022

2022Article

Licochalcone H induces cell cycle arrest and apoptosis in human skin cancer cells by modulating JAK2/STAT3 signalingBiomolecules & Therapeutics, vol. 30, no. 1, pp. 72-79K H Park; S H Joo; J H Seo; J Kim; G Yoon; Young Joo Jeon; M H Lee; J I Chae; W K Kim; J H Shim
Article
35 2022

2022Article

Second-generation JK-206 targets the oncogenic signal mediator RHOA in gastric cancerCancers, vol. 14, no. 7, pp. 1604-1604M Beak; S Park; J H Kim; H J Eom; Ho-Yeon Lee; Y H Kim; Jinhyuk Lee; S Nam
Article
36 2022

2022Article

Structural and biochemical analysis of the PTPN4 PDZ domain bound to the C-terminal tail of the human papillomavirus E6 oncoproteinJournal of Microbiology, vol. 60, no. 4, pp. 395-401Hye Seon Lee; Hye-Yeoung Yun; Eun-Woo LeeHo-Chul ShinSeung Jun KimBonsu Ku
Article
37 2022

2022Article

Global proteomic analysis of mesenchymal stem cells derived from human embryonic stem cells via connective tissue growth factor treatment under chemically defined feeder-free culture conditionsJournal of Microbiology and Biotechnology, vol. 32, no. 1, pp. 126-140J H Seo; Young Joo Jeon
Article
38 2022

2022Article

A comprehensive evaluation of regression-based drug responsiveness prediction models, using cell viability inhibitory concentrations (IC50 values)Bioinformatics, vol. 38, no. 10, pp. 2810-2817A Park; M Joo; K Kim; W J Son; GyuTae Lim; Jinhyuk Lee; J H Kim; D H Lee; S Nam
Article
39 2022

2022Article

Ligation-free isothermal nucleic acid amplificationBiosensors & Bioelectronics, vol. 209, pp. 114256-114256Jeong Moon; Jayeon Song; Hyowon Jang; Hyunju Kang; Y M Huh; H Y Son; H W Rho; M Park; Chandana Shiva Talwar; Kwang Hyun Park, et al.
Article
40 2022

2022Article

PATHOME-Drug: a subpathway-based poly-pharmacology drug-repositioning methodBioinformatics, vol. 38, no. 2, pp. 444-452S Nam; S Lee; S Park; Jinhyuk Lee; A Park; Y H Kim; T Park
Article
1 2 3 4 5 6 7 8 9 10 11 21