Disease Target Structure Research Center (질환표적구조연구센터)636

연구분야

  • 질환표적 단백질의 구조 및 기능에 관한 연구
    • X-선 결정학(X-ray crystallography) 및 핵자기공명학(NMR spectroscopy)을 이용한 세포사멸, 세포분열, 암세포 생성 등 세포신호전달 조절 단백질들의 삼차구조 및 작용기작 규명
    • 질환표적 제어를 위한 구조 기반 약물 개발
  • 단백체학 기반 질환표적 단백질 발굴 및 검증
    • 단백체학 기반 세포사멸 interactome 분석
    • 아토피성 피부염, 천식, 류마티스성 관절염 등 면역질환 생체지표의 발굴 및 기능성 검증
  • 동물모델 기반 퇴행성질환 제어 연구
    • 맞춤형 다중 퇴행성뇌질환 표현형 동물모델 (초파리 및 제브라피쉬) 평가 플랫폼 확립
    • 퇴행성뇌질환 동물모델 기반 신규 후보물질 및 바이오마커 기작 연구
  • 세포신호전달 연구를 통한 신약개발
    • GPCR, Wnt, mTOR 등 다양한 세포신호전달 기전 연구
    • 다양한 활성평가법을 이용한 유효물질 발굴 및 선도물질 도출
  • 나노포어 (Nanopore) 기반 단백질 및 RNA 센싱 연구
    • 나노포어를 이용한 약물 스크리닝 기술 개발
더보기

Showing results 81 to 100 of 415

No. Year Title Type
81 2020

2020Article

Biological and computational studies for dual cholinesterases inhibitory effect of zerumboneNutrients, vol. 12, pp. 1215-1215J Hwang; K Youn; Y Ji; S Lee; Gyutae Lim; Jinhyuk Lee; C T Ho; S H Leem; M Jun
Article
82 2020

2020Article

Crystal structure of the mouse endonuclease GBiochemical and Biophysical Research Communications, vol. 526, pp. 35-40Kwang Hyun Park; S M Yoon; H N Song; Joon-Hyuck Yang; S E Ryu; Eui-jeon Woo
Article
83 2020

2020Article

Tetrameric architecture of an active phenol-bound form of the AAA+ transcriptional regulator DmpRNature Communications, vol. 11, pp. 2728-2728Kwang Hyun Park; S Kim; Su-Jin Lee; J E Cho; V V Patil; A B Dumbrepatil; H N Song; Woo-Chan Ahn; C Joo; Seung Goo Lee, et al.
Article
84 2020

2020Article

Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammationScientific Reports, vol. 10, pp. 10755-10755Mihee Oh; Sun Young Kim; Jung-Eun Gil; Jeong Su Byun; Dong-Wook Cha; Bonsu Ku; W Lee; Won Kon KimKyoung-Jin OhEun-Woo Lee, et al.
Article
85 2020

2020Article

Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinaseBMB Reports, vol. 53, no. 7, pp. 373-378Kidae Kim; Sung Goo ParkByoung Chul ParkJeong Hoon Kim; Sunhong Kim
Article
86 2020

2020Article

Structural and biochemical characterization of the two Drosophila low molecular weight-protein tyrosine phosphatases DARP and Primo-1Molecules and Cells, vol. 43, no. 12, pp. 1035-1045Hye Seon Lee; Yeajin Mo; Ho Chul ShinSeung Jun KimBonsu Ku
Article
87 2020

2020Article

Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimerasEuropean Journal of Medicinal Chemistry, vol. 208, pp. 112769-112769A D Takwale; Seung-Hyun Jo; Y U Jeon; H S Kim; C H Shin; H K Lee; S Ahn; C O Lee; J D Ha; Jeong Hoon Kim, et al.
Article
88 2020

2020Article

Inhibitory effect of α-ketoglutaric acid on α-glucosidase: integrating molecular dynamics simulation and inhibition kineticsJournal of Biomolecular Structure & Dynamics, vol. 38, no. 12, pp. 3496-3503S L Xiong; Gyu Tae Lim; S J Yin; Jinhyuk Lee; J R Lee; M J Hahn; J M Yang; Y D Park; G Y Qian
Article
89 2020

2020Article

ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamicsScience Translational Medicine, vol. 12, no. 566, pp. eaax3993-eaax3993M Nahm; S M Lim; Y E Kim; J Park; M Y Noh; S Lee; J E Roh; S M Hwang; C K Park; Y H Kim, et al.
Article
90 2020

2020Article

Aglycosylated antibody-producing mice for aglycosylated antibody-lectin coupled immunoassay for the quantification of tumor markers (ALIQUAT)Communications Biology, vol. 3, pp. 636-636Nan Ee Lee; Sun Hee Kim; Dae Yeul Yu; Eui-jeon Woo; M I Kim; G S Seong; S M Lee; Jeong Heon KoYong Sam Kim
Article
91 2020

2020Article

Comparative studies of the expression of creatine kinase isoforms under immune stress in Pelodiscus sinensisInternational Journal of Biological Macromolecules, vol. 162, pp. 11-23C Li; W Wang; Jinhyuk Lee; L Zeng; Y Yang; S J Yin; Y D Park; G Y Qian
Article
92 2020

2020Article

Combination treatment with GSK126 and pomalidomide induces B-cell differentiation in EZH2 gain-of-function mutant diffuse large B-cell lymphomaCancers, vol. 12, no. 9, pp. 2541-2541Seongryul Park; Seung-Hyun Jo; Jong Hwan KimSeon-Young Kim; J D Ha; J Y Hwang; Myeong Youl LeeJong Soon KangTae Su HanSung Goo Park, et al.
Article
93 2020

2020Article

Crystal structure of the Csm5 subunit of the type III-A CRISPR-Cas systemBiochemical and Biophysical Research Communications, vol. 523, pp. 112-116Y An; Kwang Hyun Park; Minho Lee; T J Kim; Eui-Jeon Woo
Article
94 2020

2020Article

The tumor suppressor, p53, negatively regulates non-canonical NF-κB signaling through miRNA-induced silencing of NF-κB-inducing kinaseMolecules and Cells, vol. 43, no. 1, pp. 23-33Hanbit Jang; Seulki Park; J Kim; Jong Hwan KimSeon-Young Kim; S Cho; Sung Goo ParkByoung Chul Park; Sunhong Kim; Jeong Hoon Kim
Article
95 2020

2020Article

Neuroprotective effects of cryptotanshinone in a direct reprogramming model of Parkinson's diseaseMolecules, vol. 25, no. 16, pp. 3602-3602Joo-Eun Lee; Hyuna Sim; H M Yoo; Minhyung Lee; Areum BaekYoung Joo Jeon; K S Seo; Mi Young Son; J S Yoon; Janghwan Kim
Article
96 2020

2020Article

Quantitative proteomic analysis of primitive neural stem cells from LRRK2 G2019S-associated Parkinson's disease patient-derived iPSCsLife-Basel, vol. 10, no. 12, pp. 331-331Hyuna Sim; J H Seo; J Kim; Minyoung Oh; Joo-Eun Lee; Areum Baek; S Y Lee; S K Chung; Mi-Young Son; J I Chae, et al.
Article
97 2020

2020Article

Iroquois homeobox protein 2 identified as a potential Biomarker for Parkinson’s diseaseInternational Journal of Molecular Sciences, vol. 21, no. 10, pp. 3455-3455Hyuna Sim; Joo-Eun Lee; H M Yoo; Sunwha Cho; Hana LeeAruem Baek; J Kim; H Seo; M N Kweon; h G Kim, et al.
Article
98 2019

2019Article

A deep learning model for cell growth inhibition IC50 prediction and its application for gastric cancer patientsInternational Journal of Molecular Sciences, vol. 20, pp. 6276-6276M Joo; A Park; K Kim; W J Son; H S Lee; Gyu Tae Lim; Jinhyuk Lee; D H Lee; J An; J H Kim, et al.
Article
99 2019

2019Article

The inhibitory effect of pyrogallol on tyrosinase activity and structure: integration study of inhibition kinetics with molecular dynamics simulationInternational Journal of Biological Macromolecules, vol. 121, pp. 463-471S L Xiong; Gyu Tae Lim; S J Yin; Jinhyuk Lee; Y X Si; J M Yang; Y D Park; G Y Qian
Article
100 2019

2019Article

Inhibitory effect of phloroglucinol on α-glucosidase: Kinetics and molecular dynamics simulation integration studyInternational Journal of Biological Macromolecules, vol. 124, pp. 771-779J X Wan; Gyutae Lim; Jinhyuk Lee; X B Sun; D Y Gao; Y X Si; X L Shi; G Y Qian; Q Wang; Y D Park
Article
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