Disease Target Structure Research Center (질환표적구조연구센터)636

연구분야

  • 질환표적 단백질의 구조 및 기능에 관한 연구
    • X-선 결정학(X-ray crystallography) 및 핵자기공명학(NMR spectroscopy)을 이용한 세포사멸, 세포분열, 암세포 생성 등 세포신호전달 조절 단백질들의 삼차구조 및 작용기작 규명
    • 질환표적 제어를 위한 구조 기반 약물 개발
  • 단백체학 기반 질환표적 단백질 발굴 및 검증
    • 단백체학 기반 세포사멸 interactome 분석
    • 아토피성 피부염, 천식, 류마티스성 관절염 등 면역질환 생체지표의 발굴 및 기능성 검증
  • 동물모델 기반 퇴행성질환 제어 연구
    • 맞춤형 다중 퇴행성뇌질환 표현형 동물모델 (초파리 및 제브라피쉬) 평가 플랫폼 확립
    • 퇴행성뇌질환 동물모델 기반 신규 후보물질 및 바이오마커 기작 연구
  • 세포신호전달 연구를 통한 신약개발
    • GPCR, Wnt, mTOR 등 다양한 세포신호전달 기전 연구
    • 다양한 활성평가법을 이용한 유효물질 발굴 및 선도물질 도출
  • 나노포어 (Nanopore) 기반 단백질 및 RNA 센싱 연구
    • 나노포어를 이용한 약물 스크리닝 기술 개발
더보기

Showing results 141 to 160 of 415

No. Year Title Type
141 2018

2018Article

Crystallization and preliminary diffraction analysis of human TEAD1, a transcriptional enhancer factor that controls the Hippo signaling pathwayBiodesign, vol. 6, no. 3, pp. 56-59Yeajin Mo; Hye Seon Lee; C H Lee; H J Lim; S J Park; Ho-Chul ShinSeung Jun KimBonsu Ku
Article
142 2018

2018Article

Identification of N-(5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl)acetamide derivatives as novel protein tyrosine phosphatase epsilon inhibitors exhibiting anti-osteoclastic activityBioorganic & Medicinal Chemistry, vol. 26, no. 18, pp. 5204-5211Bonsu Ku; Hye-Yeoung Yoon; Kyuong Won Lee; Ho Chul Shin; Sang-Rae Lee; C H Kim; H Park; K Y Lee; Chang Hoon Lee; Seung Jun Kim
Article
143 2018

2018Article

Peroxisome proliferator-activated receptor α agonist and its target Nanog cooperate to induce pluripotency = 전분화능 획득 조절 PPAR 알파 길항제Journal of Clinical Medicine, vol. 7, no. 12, pp. 488-488Jungwoon LeeJinhyuk LeeYee Sook Cho
Article
144 2017

2017Article

Dual-specificity phosphatase 5 acts as an anti-inflammatory regulator by inhibiting the ERK and NF-κB signaling pathwaysScientific Reports, vol. 7, pp. 17348-17348H Seo; Y C Cho; A Ju; S Lee; Byoung Chul ParkSung Goo ParkJeong Hoon Kim; K Kim; S Cho
Article
145 2017

2017Article

Purification, crystallization and X-ray crystallographic analysis of Csm5 in Type III-A Crispr-Cas systemBiodesign, vol. 5, no. 2, pp. 62-65Yan An; Kwang Hyun Park; Minho Lee; Woo-Chan Ahn; In-Young Baek; T J Kim; Eui-Jeon Woo
Article
146 2017

2017Article

Methyl 3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a novel and dual malate dehydrogenase (MDH) 1/2 inhibitor targeting cancer metabolismJournal of Medicinal Chemistry, vol. 60, no. 20, pp. 8631-8646R Naik; Hyun Seung Ban; K Jang; I Kim; X Xu; D Harmalkar; S A Shin; M Kim; Bo Kyung Kim; J Park, et al.
Article
147 2017

2017Article

The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: kinetics and molecular dynamics simulation studyInternational Journal of Biological Macromolecules, vol. 105, no. 3, pp. 1654-1662L Gou; Jinhyuk Lee; J M Yang; Y D Park; H M Zhou; Y Zhan; Z R Lu
Article
148 2017

2017Article

Inhibition of tyrosinase by fumaric acid: integration of inhibition kinetics with computational docking simulationsInternational Journal of Biological Macromolecules, vol. 105, no. 3, pp. 1663-1669L Gou; Jinhyuk Lee; J M Yang; Y D Park; H M Zhou; Y Zhan; Z R Lu
Article
149 2017

2017Article

Hydrogen peroxide (H2O2) irreversibly inactivates creatine kinase from Pelodiscus sinensis by targeting the active site cysteineInternational Journal of Biological Macromolecules, vol. 105, no. 3, pp. 1595-1601W Wang; Jinhyuk Lee; H Hao; Y D Park; G Y Qian
Article
150 2017

2017Article

Two-track virtual screening approach to identify both competitive and allosteric inhibitors of human small C-terminal domain phosphatase 1Journal of Computer-Aided Molecular Design, vol. 31, no. 8, pp. 743-753H Park; Hye Seon Lee; Bonsu Ku; Sang-Rae Lee; Seung Jun Kim
Article
151 2017

2017Article

Towards binding mechanism of Cu2+ on creatine kinase from Pelodiscus sinensis : molecular dynamics simulation integrating inhibition kinetics studyProtein and Peptide Letters, vol. 24, no. 6, pp. 534-544Y Cai; Jinhyuk Lee; W Wang; Y D Park; G Y Qian
Article
152 2017

2017Article

Stably fluorescent cell line of human ovarian epithelial cancer cells SK-OV-3ip-redBulletin of Experimental Biology and Medicine, vol. 164, no. 1, pp. 99-101E V Konovalova; A A Shulga; S P Chumakov; Y M Khodarovich; Eui-Jeon Woo; S M Deev
Article
153 2017

2017Article

Polymethoxyflavones: novel β-secretase (BACE1) inhibitors from citrus peelsNutrients, vol. 9, no. 9, pp. 973-973K Youn; Y Yu; Jinhyuk Lee; W S Jeong; C T Ho; M Jun
Article
154 2017

2017Article

Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPaseArchives of Virology, vol. 162, no. 11, pp. 3407-3416Bonsu Ku; Jin A You; Kyoung Jin Oh; Hye Yeoung Yun; Hye Seon Lee; Ho Chul ShinJuyeon JungYong Beom ShinSeung Jun Kim
Article
155 2017

2017Article

Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28PLoS One, vol. 12, no. 11, pp. e0187701-e0187701Bonsu Ku; W Hong; Chae Won Keum; M Kim; H Ryu; D Jeon; Ho Chul Shin; J H Kim; Seung Jun Kim; S E Ryu
Article
156 2017

2017Article

The discovery of novel protein tyrosine phosphatase ε inhibitors using a high-throughput screening approachBulletin of Korean Chemical Society, vol. 38, no. 1, pp. 44-53Hye-Yeoung Yun; Bonsu Ku; Hye Seon Lee; Ho-Chul Shin; J B Park; C H Kim; Seung Jun Kim
Article
157 2017

2017Article

RNA activation-independent DNA targeting of the Type III CRISPR-Cas system by a Csm complexEMBO Reports, vol. 18, no. 5, pp. 826-840Kwang Hyun Park; Yan An; T Y Jung; In-Young Baek; H Noh; Woo-Chan Ahn; H Hebert; J J Song; Jeong Hoon Kim; B H Oh, et al.
Article
158 2017

2017Article

Histone lysine methylation and neurodevelopmental disordersInternational Journal of Molecular Sciences, vol. 18, no. 7, pp. 1404-1404Jeong Hoon Kim; J H Lee; I S Lee; S B Lee; K S Cho
Article
159 2017

2017Article

The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3 = TRAF3의 miRNA 유도 번역저해를 통한 p90RSK-UBR5 신호전달계의 Toll-like 수용체 신호 조절Journal of Biological Chemistry, vol. 292, no. 28, pp. 11804-11814Jin Hwa Cho; Sung Ah Kim; Y S Seo; Sung Goo ParkByoung Chul ParkJeong-Hoon Kim; Sunhong Kim
Article
160 2017

2017Article

Inhibitory effect of hesperetin on α-glucosidase: Molecular dynamics simulation integrating inhibition kineticsInternational Journal of Biological Macromolecules, vol. 101, pp. 32-39Y Gong; X Y Qin; Y Y Zhai; H Hao; Jinhyuk Lee; Y D Park
Article
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