Disease Target Structure Research Center (질환표적구조연구센터)603

연구분야

  • 질환표적 단백질의 구조 및 기능에 관한 연구
    • X-선 결정학(X-ray crystallography) 및 핵자기공명학(NMR spectroscopy)을 이용한 세포사멸, 세포분열, 암세포 생성 등 세포신호전달 조절 단백질들의 삼차구조 및 작용기작 규명
    • 질환표적 제어를 위한 구조 기반 약물 개발
  • 단백체학 기반 질환표적 단백질 발굴 및 검증
    • 단백체학 기반 세포사멸 interactome 분석
    • 아토피성 피부염, 천식, 류마티스성 관절염 등 면역질환 생체지표의 발굴 및 기능성 검증
  • 동물모델 기반 퇴행성질환 제어 연구
    • 맞춤형 다중 퇴행성뇌질환 표현형 동물모델 (초파리 및 제브라피쉬) 평가 플랫폼 확립
    • 퇴행성뇌질환 동물모델 기반 신규 후보물질 및 바이오마커 기작 연구
  • 세포신호전달 연구를 통한 신약개발
    • GPCR, Wnt, mTOR 등 다양한 세포신호전달 기전 연구
    • 다양한 활성평가법을 이용한 유효물질 발굴 및 선도물질 도출
  • 나노포어 (Nanopore) 기반 단백질 및 RNA 센싱 연구
    • 나노포어를 이용한 약물 스크리닝 기술 개발
더보기

Showing results 1 to 20 of 384

No. Year Title Type
1 2023

2023Article

Discovery of pan-IAP degraders via a CRBN recruiting mechanismEuropean Journal of Medicinal Chemistry, vol. 245, no. 2, pp. 114910-114910Seulki Park; D Kim; W Lee; Jin Hwa Cho; Sungyoung Kim; Ga Seul Lee; Jeong Hee MoonJung Ae Kim; J D Ha; Jeong Hoon Kim, et al.
Article
2 2022

2022Article

PATHOME-Drug: a subpathway-based poly-pharmacology drug-repositioning methodBioinformatics, vol. 38, no. 2, pp. 444-452S Nam; S Lee; S Park; Jinhyuk Lee; A Park; Y H Kim; T Park
Article
3 2022

2022Article

Second-generation JK-206 targets the oncogenic signal mediator RHOA in gastric cancerCancers, vol. 14, no. 7, pp. 1604-1604M Beak; S Park; J H Kim; H J Eom; Ho-Yeon Lee; Y H Kim; Jinhyuk Lee; S Nam
Article
4 2022

2022Article

Binding mode of brazzein to the taste receptor based on crystal structure and docking simulationBiochemical and Biophysical Research Communications, vol. 592, pp. 119-124Tae-Yeon Kim; Euijeon WooTae-Sung Yoon
Article
5 2022

2022Article

Global proteomic analysis of mesenchymal stem cells derived from human embryonic stem cells via connective tissue growth factor treatment under chemically defined feeder-free culture conditionsJournal of Microbiology and Biotechnology, vol. 32, no. 1, pp. 126-140J H Seo; Young Joo Jeon
Article
6 2022

2022Article

Novel GPR43 agonists exert an anti-Inflammatory effect in a colitis modelBiomolecules & Therapeutics, vol. 30, no. 1, pp. 48-54Bioh Park; Jong Soon Kang; S Paudel; Sung Goo ParkByoung Chul Park; S B Han; Y S Kwak; Jeong Hoon Kim; Sunhong Kim
Article
7 2022

2022Article

Licochalcone H induces cell cycle arrest and apoptosis in human skin cancer cells by modulating JAK2/STAT3 signalingBiomolecules & Therapeutics, vol. 30, no. 1, pp. 72-79K H Park; S H Joo; J H Seo; J Kim; G Yoon; Young Joo Jeon; M H Lee; J I Chae; W K Kim; J H Shim
Article
8 2022

2022Article

Marine invertebrate sialyltransferase of the sea squirt Ciona savignyi sialylated core 1 O-linked glycansInternational Journal of Biological Macromolecules, vol. 194, pp. 366-376Seonghun KimJinhyuk LeeDoo-Byoung OhOhsuk Kwon
Article
9 2022

2022Article

A comprehensive evaluation of regression-based drug responsiveness prediction models, using cell viability inhibitory concentrations (IC50 values)Bioinformatics, vol. 38, no. 10, pp. 2810-2817A Park; M Joo; K Kim; W J Son; GyuTae Lim; Jinhyuk Lee; J H Kim; D H Lee; S Nam
Article
10 2022

2022Article

Dimeric architecture of maltodextrin glucosidase (MalZ) provides insights into the substrate recognition and hydrolysis mechanismBiochemical and Biophysical Research Communications, vol. 586, pp. 49-54Woo-Chan Ahn; Yan An; K M Song; Kwang Hyun Park; Sujin Lee; B H Oh; J T Park; Euijeon Woo
Article
11 2022

2022Article

Artificial intelligence-based identification of octenidine as a Bcl-xL inhibitorBiochemical and Biophysical Research Communications, vol. 588, pp. 97-103A R N Bui; H Son; Seulki Park; Sohee Oh; Jin Sik Kim; Jin Hwa Cho; Hye-Jin Hwang; Jeong Hoon Kim; G S Yi; Seung-Wook Chi
Article
12 2022

2022Article

One-step synthesis of glycogen-type polysaccharides from maltooctaose and its structural characteristicsCarbohydrate Polymers, vol. 284, pp. 119175-119175P L Tran; Yan An; G Y Jeong; S Y Ban; P C Nguyen; Euijeon Woo; S You; J T Park
Article
13 2022

2022Article

Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse modelBioorganic Chemistry, vol. 127, pp. 105923-105923A D Takwale; E Y Kim; Y Jang; D H Lee; S Kim; Y Choi; J H Kim; D Y Lee; Y Kim; S M Lee, et al.
Article
14 2022

2022Article

Structural and biochemical analysis of the PTPN4 PDZ domain bound to the C-terminal tail of the human papillomavirus E6 oncoproteinJournal of Microbiology, vol. 60, no. 4, pp. 395-401Hye Seon Lee; Hye-Yeoung Yun; Eun-Woo LeeHo-Chul ShinSeung Jun KimBonsu Ku
Article
15 2022

2022Article

Ligation-free isothermal nucleic acid amplificationBiosensors & Bioelectronics, vol. 209, pp. 114256-114256Jeong Moon; Jayeon Song; Hyowon Jang; Hyunju Kang; Y M Huh; H Y Son; H W Rho; M Park; Chandana Shiva Talwar; Kwang Hyun Park, et al.
Article
16 2022

2022Article

Downregulation of SETD5 suppresses the tumorigenicity of hepatocellular carcinoma cellsMolecules and Cells, vol. 45, no. 8, pp. 550-563Mijin Park; Byul Moon; Jong-Hwan Kim; Seung-Jin Park; Seon-Kyu Kim; K Park; J Kim; Seon-Young KimJeong Hoon KimJung Ae Kim
Article
17 2022

2022Article

Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1Biochemical and Biophysical Research Communications, vol. 625, pp. 174-180Dahwan Lim; Sein Jin; Ho-Chul Shin; W Kim; J S Choi; Doo-Byoung OhSeung Jun KimJinho SeoBonsu Ku
Article
18 2022

2022Article

Deoxypodophyllotoxin induces ROS-mediated apoptosis by modulating the PI3K/AKT and p38 MAPK-dependent signaling in oral squamous cell carcinomaJournal of Microbiology and Biotechnology, vol. 32, no. 9, pp. 1103-1109J H Seo; G Yoon; Seryoung Park; J H Shim; J I Chae; Young Joo Jeon
Article
19 2022

2022Article

A study of Pb2+ induced unfolding and aggregation of arginine kinase from Euphausia superba: kinetics and computational simulation integrating studyJournal of Biomolecular Structure & Dynamics, vol. 40, no. 18, pp. 8206-8215S J Yin; Jinhyuk Lee; Gyu Tae Lim; Z Chen; G Y Qian; Y X Si; Y D Park
Article
20 2022

2022Article

Acceptor dependent catalytic properties of GH57 4-α-glucanotransferase from Pyrococcus sp. ST04Frontiers in Microbiology, vol. 13, pp. 1016675-1016675J H Jung; S Hong; E J Jeon; M K Kim; D H Seo; Eui-Jeon Woo; J F Holden; C S Park
Article
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