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Disease Target Structure Research Center (질환표적구조연구센터)635

연구분야

질환표적 단백질의 구조 및 기능에 관한 연구
- X-선 결정학(X-ray crystallography) 및 핵자기공명학(NMR spectroscopy)을 이용한 세포사멸, 세포분열, 암세포 생성 등 세포신호전달 조절 단백질들의 삼차구조 및 작용기작 규명
- 질환표적 제어를 위한 구조 기반 약물 개발
단백체학 기반 질환표적 단백질 발굴 및 검증
- 단백체학 기반 세포사멸 interactome 분석
- 아토피성 피부염, 천식, 류마티스성 관절염 등 면역질환 생체지표의 발굴 및 기능성 검증
동물모델 기반 퇴행성질환 제어 연구
- 맞춤형 다중 퇴행성뇌질환 표현형 동물모델 (초파리 및 제브라피쉬) 평가 플랫폼 확립
- 퇴행성뇌질환 동물모델 기반 신규 후보물질 및 바이오마커 기작 연구
세포신호전달 연구를 통한 신약개발
- GPCR, Wnt, mTOR 등 다양한 세포신호전달 기전 연구
- 다양한 활성평가법을 이용한 유효물질 발굴 및 선도물질 도출
나노포어 (Nanopore) 기반 단백질 및 RNA 센싱 연구
- 나노포어를 이용한 약물 스크리닝 기술 개발

Showing results 1 to 20 of 411

No.	Year	Title	Type
1	2023	2023Article Influenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell deathCell Death & Disease, vol. 14, no. 3, pp. 228-228Chang Ung Kim; Dahwan Lim; Y S Kim; Bonsu Ku; Doo-Jin Kim	Article
2	2023	2023Article CDK9 inhibitors downregulate DKK1 expression to suppress the metastatic potential of HCC cellsGenes & Genomics, vol. 45, no. 3, pp. 285-293Mijin Park; Jin Hwa Cho; Byul Moon; Jeong Hoon Kim; Jung Ae Kim	Article
3	2023	2023Article Discovery of pan-IAP degraders via a CRBN recruiting mechanismEuropean Journal of Medicinal Chemistry, vol. 245, no. 2, pp. 114910-114910Seulki Park; D Kim; W Lee; Jin Hwa Cho; Sungyoung Kim; Ga Seul Lee; Jeong Hee Moon; Jung Ae Kim; J D Ha; Jeong Hoon Kim, et al.	Article
4	2023	2023Article Characterization and tissue expression analysis of mitochondrial creatine kinases (types I and II) from Pelodiscus sinensisJournal of Biomolecular Structure & Dynamics, vol. 41, no. 4, pp. 1388-1402L F Zeng; Jinhyuk Lee; Gyutae Lim; Y F Yang; R L Lin; S J Yin; W Wang; Y D Park	Article
5	2023	2023Article Neuroprotective effects of licochalcone D in oxidative-stress-induced primitive neural stem cells from Parkinson's disease patient-derived iPSCsBiomedicines, vol. 11, no. 1, pp. 228-228Minyoung Oh; Juhyeon Nam; Areum Baek; J H Seo; J I Chae; S Y Lee; S K Chung; Byoung Chul Park; Sung Goo Park; Janghwan Kim, et al.	Article
6	2023	2023Article Identification of new N-methyl-piperazine chalcones as dual MAO-B/AChE inhibitorsPharmaceuticals, vol. 16, no. 1, pp. 83-83A K El-Damasy; J E Park; H J Kim; Jinhyuk Lee; E K Bang; H Kim; G Keum	Article
7	2023	2023Article Shear stress induces monocyte/macrophage-mediated inflammation by upregulating cell-surface expression of heat shock proteinsBiomedicine & Pharmacotherapy, vol. 161, pp. 114566-114566H Son; H S Choi; S E Baek; Y H Kim; J Hur; J H Han; Jeong Hee Moon; Ga Seul Lee; Sung Goo Park; C H Woo, et al.	Article
8	2023	2023Article Verproside, the most active ingredient in YPL-001 isolated from Pseudolysimachion rotundum var. subintegrum, decreases inflammatory response by inhibiting PKCδ activation in human lung epithelial cellsInternational Journal of Molecular Sciences, vol. 24, no. 8, pp. 7229-7229Eun Sol Oh; Hyung Won Ryu; Mun-Ock Kim; Jae-Won Lee; Yu Na Song; Ji-Yoon Park; Doo-Young Kim; H Ro; Jinhyuk Lee; Tae-Don Kim, et al.	Article
9	2023	2023Article Construction of deep learning-based disease detection model in plantsScientific Reports, vol. 13, pp. 7331-7331Minah Jung; J S Song; Ah Young Shin; Beomjo Choi; Sangjin Go; Suk Yoon Kwon; J Park; Sung Goo Park; Yong Min Kim	Article
10	2023	2023Article A fluorescent probe to simultaneously detect both O-GlcNAcase and phosphataseFrontiers in Chemistry, vol. 11, pp. 1133018-1133018J Boo; J Lee; Y H Kim; C H Lee; Bonsu Ku; I Shin	Article
11	2023	2023Article Structural analysis of the interaction between Bcl-xL and the noncanonical BH3 domain of non-Bcl-2 family proteinsCurrent Protein & Peptide Science, vol. 24, no. 4, pp. 296-306Bonsu Ku	Article
12	2023	2023Article Hypoxia stabilizes SETDB1 to maintain genome stabilityNucleic Acids Research, vol. 51, no. 20, pp. 11178-11196Sungryul Park; Jin Hwa Cho; Jong-Hwan Kim; Mijin Park; Seulki Park; Seon-Young Kim; Seon-Kyu Kim; K Kim; Sung Goo Park; Byoung Chul Park, et al.	Article
13	2023	2023Article Mutational and structural analyses of UdgX: insights into the active site pocket architecture and its evolutionNucleic Acids Research, vol. 51, no. 13, pp. 6554-6565S Aroli; Euijeon Woo; B Gopal; U Varshney	Article
14	2023	2023Article Crystal structures of Plk1 polo-box domain bound to the human papillomavirus minor capsid protein L2-derived peptideJournal of Microbiology, vol. 61, pp. 755-764Sujin Jung; Hye Seon Lee; Ho Chul Shin; J S Choi; Seung Jun Kim; Bonsu Ku	Article
15	2023	2023Article The distinctive permutated domain structure of periplasmic α-amylase (MalS) from glycoside hydrolase family 13 subfamily 19Molecules, vol. 28, no. 10, pp. 3972-3972Yan An; P L Tran; M J Yoo; Hyung-Nam Song; Kwang Hyun Park; T J Kim; J T Park; Euijeon Woo	Article
16	2023	2023Article Design of hypoxia responsive CRISPR-Cas9 for target gene regulationScientific Reports, vol. 13, pp. 16763-16763Yan An; C S Talwar; Kwang Hyun Park; Woo-Chan Ahn; Su-Jin Lee; Seong Ryeong Go; Jin Hwa Cho; Do Yon Kim; Yong-Sam Kim; S Cho, et al.	Article
17	2023	2023Article Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male miceNature Communications, vol. 14, pp. 3746-3746Anna Park; K E Kim; I Park; S H Lee; K Y {Park; M Jung; x Li; M B Sleiman; Su Jeong Lee; Dae Soo Kim, et al.	Article
18	2023	2023Article Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1PLoS Biology, vol. 21, no. 6, pp. e3002156-e3002156Dahwan Lim; So Hui Choe; Sein Jin; S Lee; Y Kim; Ho Chul Shin; J S Choi; Doo-Byoung Oh; Seung Jun Kim; Jinho Seo, et al.	Article
19	2023	2023Article Efficient valorization of food waste oils to renewable biodiesel by a Candida antarctica lipase B mutant that catalyzes the ester synthesis reaction in the presence of waterJournal of Cleaner Production, vol. 428, pp. 139336-139336Hyun Jun Ko; Mi-Jin Kim; H J Kim; Jin Kang; Ho-Yeon Lee; Jinhyuk Lee; Jung Hoon Bae; Bong Hyun Sung; Jung Hoon Sohn	Article
20	2023	2023Article Improving geometric validation metrics and ensuring consistency with experimental data through TrioSA: an NMR re？nement protocol = 실험 데이터와 일관성을 보장하고 TrioSA를 통한 NMR 정제 프로토콜을 통해 기하학적 검증 지표를 개선하는 방법International Journal of Molecular Sciences, vol. 24, no. 17, pp. 13337-13337Youngbeom Cho; Hyojung Ryu; Gyutae Lim; S Nam; Jinhyuk Lee	Article

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