Disease Target Structure Research Center (질환표적구조연구센터)519

연구분야

  • 질환표적 단백질의 구조 및 기능에 관한 연구
    • X-선 결정학(X-ray crystallography) 및 핵자기공명학(NMR spectroscopy)을 이용한 세포사멸, 세포분열, 암세포 생성 등 세포신호전달 조절 단백질들의 삼차구조 및 작용기작 규명
    • 질환표적 제어를 위한 구조 기반 약물 개발
  • 단백체학 기반 질환표적 단백질 발굴 및 검증
    • 단백체학 기반 세포사멸 interactome 분석
    • 아토피성 피부염, 천식, 류마티스성 관절염 등 면역질환 생체지표의 발굴 및 기능성 검증
  • 동물모델 기반 퇴행성질환 제어 연구
    • 맞춤형 다중 퇴행성뇌질환 표현형 동물모델 (초파리 및 제브라피쉬) 평가 플랫폼 확립
    • 퇴행성뇌질환 동물모델 기반 신규 후보물질 및 바이오마커 기작 연구
  • 세포신호전달 연구를 통한 신약개발
    • GPCR, Wnt, mTOR 등 다양한 세포신호전달 기전 연구
    • 다양한 활성평가법을 이용한 유효물질 발굴 및 선도물질 도출
  • 나노포어 (Nanopore) 기반 단백질 및 RNA 센싱 연구
    • 나노포어를 이용한 약물 스크리닝 기술 개발
더보기

Showing results 1 to 20 of 467

No. Year Title Type
1 2021

2021Article

Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brainNature Cell Biology, vol. 23, no. 2, pp. 172-183Eunbyul Yeom; H Shin; Wonbeak Yoo; E Jun; S Kim; Seung Hyun Hong; Dae Woo Kwon; Tae Hoon Ryu; J M Suh; S C Kim, et al.
Article
2 2021

2021Article

Molecular analysis of the interaction between human PTPN21 and the oncoprotein E7 from human papillomavirus genotype 18Molecules and Cells, vol. 44, no. 1, pp. 26-37Hye Seon Lee; Min Wook Kim; K S Jin; Ho-Chul ShinWon Kon KimSang Chul LeeSeung Jun KimEun-Woo LeeBonsu Ku
Article
3 2021

2021Article

Tertiary RNA folding-targeted drug screening strategy using a protein nanoporeAnalytical Chemistry, vol. 93, no. 5, pp. 2811-2819Dong-Hwa Lee; Sohee Oh; Kyungeun Lim; B Lee; G S Yi; Y R Kim; K B Kim; C K Lee; Seung-Wook ChiMi-Kyung Lee
Article
4 2021

2021Article

Sjogren syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and humanBiochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol. 1864, pp. 194684-194684Seong Heon Kim; Bi-Oh Park; Kidae Kim; Byoung Chul ParkSung Goo ParkJeong Hoon Kim; S Kim
Article
5 2021

2021Article

Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathwaysCell Death and Differentiation, vol. 28, no. 3, pp. 900-914Jin Hwa Cho; Kidae Kim; Sung Ah Kim; Seongryul Park; Bi-Oh Park; Jong-Hwan Kim; Seon-Young Kim; M J Kwon; M H Han; S B Lee, et al.
Article
6 2021

2021Article

UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradationNature Communications, vol. 12, pp. 3291-3291M Subramanian; S J Hyeon; T Das; Yoon Seok Suh; Y K Kim; Jeong Soo Lee; E J Song; H Ryu; Kweon Yu
Article
7 2021

2021Article

Global proteomics to study silica nanoparticle-induced cytotoxicity and is mechanisms in HepG2 cellsBiomolecules, vol. 11, no. 3, pp. 375-375S Y Lee; I Y Kim; M B Heo; Jeong Hee Moon; J G Son; T G Lee
Article
8 2021

2021Article

Crystal structure of human LC8 bound to a peptide from Ebola virus VP35Journal of Microbiology, vol. 59, no. 4, pp. 410-416Dahwan Lim; Ho Chul Shin; J S Choi; Seung Jun KimBonsu Ku
Article
9 2021

2021Article

Genetic approaches using zebrafish to study the microbiota-gut-brain axis in neurological disordersCells, vol. 10, no. 3, pp. 566-566Jae-Geun Lee; Hyun-Ju Cho; Yun-Mi Jeong; Jeong Soo Lee
Article
10 2021

2021Article

Eif2b3 mutants recapitulate phenotypes of vanishing white matter disease and validate novel disease alleles in zebrafishHuman Molecular Genetics, vol. 30, no. 5, pp. 331-342Y R Lee; S H Kim; A Ben-Mahmoud; O H Kim; T I Choi; K H Lee; Bonsu Ku; J Eum; Y Kee; S Lee, et al.
Article
11 2021

2021Article

R-catcher, a potent molecular tool to unveil the arginylomeCellular and Molecular Life Sciences, vol. 78, no. 7, pp. 3725-3741Taewook Seo; Jihyo Kim; Ho Chul Shin; Jung Gi Kim; S Ju; L Nawale; Goeun Han; Hye Seon Lee; G Bang; J Y Kim, et al.
Article
12 2021

2021Article

Single-molecule analysis of interaction between p53TAD and MDM2 using aerolysin nanoporesChemical Science, vol. 12, no. 16, pp. 5883-5891Sohee Oh; Mi-Kyung LeeSeung-Wook Chi
Article
13 2021

2021Article

Directed evolution of glycosyltransferase for enhanced efficiency of avermectin glucosylationApplied Microbiology and Biotechnology, vol. 105, no. 11, pp. 4599-4607Ha-Young Choi; Hyun Seung Lim; Kwang Hyun Park; J Kim; Won Gon Kim
Article
14 2021

2021Article

Phosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of Transferrin receptorBMB Reports, vol. 54, no. 5, pp. 272-277Seong Heon Kim; Jin Hwa Cho; Bi-Oh Park; Byoung Chul ParkJeong Hoon KimSung Goo Park; Sunhong Kim
Article
15 2020

2020Article

Crystal structure of the Csm5 subunit of the type III-A CRISPR-Cas systemBiochemical and Biophysical Research Communications, vol. 523, pp. 112-116Y An; Kwang Hyun Park; Minho Lee; T J Kim; Eui-Jeon Woo
Article
16 2020

2020Article

Asparaginyl-tRNA synthetase, a novel component of Hippo signaling, binds to Salvador and enhances Yorkie-mediated tumorigenesisFrontiers in Cell and Developmental Biology, vol. 8, pp. 32-32Eunbyul Yeom; Dae Woo Kwon; Jaemin Lee; S H Kim; J H Lee; K J Min; Kyu-Sun LeeKweon Yu
Article
17 2020

2020Article

Differential proteomic analyses of green microalga Ettlia sp. at various dehydration levelsPlant Physiology and Biochemistry, vol. 146, pp. 198-210S Sajjad; J S Ha; Seong Hyun Seo; Tae-Sung YoonHee-Mock OhHyung Gwan LeeSunghyun Kang
Article
18 2020

2020Article

Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplicationMolecular and Cellular Biology, vol. 40, no. 10, pp. e00535-e00535Z Wei; T S Kim; J I Ahn; L Meng; Y Chen; E K Ryu; Bonsu Ku; M Zhou; Seung Jun Kim; J K Bang, et al.
Article
19 2020

2020Article

The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 geneJournal of Biological Chemistry, vol. 295, no. 39, pp. 13677-13690Jeong Su ByunMihee Oh; Seonha Lee; Jung-Eun Gil; Yeajin Mo; Bonsu KuWon Kon KimKyoung-Jin OhEun-Woo LeeKwang-Hee Bae, et al.
Article
20 2020

2020Article

Depression-like behaviors induced by defective PTPRT activity through dysregulated synaptic functions and neurogenesisJournal of Cell Science, vol. 133, pp. jcs243972-jcs243972So-Hee Lim; S Shin; M H Kim; E C Kim; Da Yong LeeJeonghee Moon; Hey-Yeon Park; Young-Kyoung Ryu; Young Mi Kang; Y J Kang, et al.
Article
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