Genome Editing Research Center (유전자교정연구센터)880

연구분야

  • 유전자 교정 기술의 고도화 연구
    • CRISPR/Cas9 및 CRISPR/cpf1 유전자 교정 기술의 효율성 증대 연구
    • 줄기세포, 질병 및 노화 관련 유전자들의 표적 조절 시스템 구축
  • 당질 유전자 교정 기술을 이용한 인간모사 마우스모델 개발
    • 인간과 마우스의 당질 차이를 유발하는 당질 유전자 선정 및 이 유전자를 교정한 마우스모델 개발
    • 인간모사 마우스의 비임상 적합성 검증
  • 신규 유전자 교정 기술 개발
    • 제 4세대 유전자 교정 기술 개발 및 효능 검증
  • 동물형질전환기술을 이용한 질환모델마우스 개발
  • 암발달과정에 있어서 항산화효소의 작용기전 연구
  • 무정형 단백질의 생물학적 활성 기전 및 질병 유발 기전 규명
  • 난치성 질환의 진단 및 치료를 위한 신규 유기 고분자/나노 화합물의 설계, 합성 및 응용
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Showing results 1 to 20 of 796

No. Year Title Type
1 2021

2021Article

Profiling genome-wide specificity of CRISPR-Cas9 using Digenome-seqMethods in Molecular Biology, vol. 2162, pp. 233-242Daesik Kim; J S Kim
Article
2 2021

2021Article

One-step genotyping method in CRISPR based on short inner primer-assisted, tetra primer-paired amplificationsMolecular and Cellular Probes, vol. 55, pp. 101675-101675Nan Ee Lee; Dae In Ha; Jeong Heon KoYong-Sam Kim
Article
3 2021

2021Article

Whole exome sequencing identifies novel de novo variants interacting with six gene networks in autism spectrum disorderGenes, vol. 12, no. 1, pp. 1-1Namshin Kim; Kyoung Hyoun Kim; Won-Jun Lim; Jiwoong Kim; S A Kim; H J Yoo
Article
4 2021

2021Article

Rapid identification of isoprenylated flavonoids constituents with inhibitory activity on bacterial neuraminidase from root barks of paper mulberry (Broussonetia papyrifera)International Journal of Biological Macromolecules, vol. 174, pp. 61-68Mi Hyeon Park; Sunin Jung; H J Yuk; Hyun-Jae Jang; Won Jun Kim; Doo-Young Kim; GyuTae Lim; Jinhyuk LeeSei-Ryang OhSu Ui Lee, et al.
Article
5 2021

2021Article

MicroRNA profile for diagnostic and prognostic biomarkers in thyroid cancerCancers, vol. 13, no. 4, pp. 632-632Jong Lyul ParkSeon-Kyu Kim; S Jeon; C K Jung; Yong Sung Kim
Article
6 2021

2021Article

Structural interplays in the flexible N-terminus and scaffolding domain of human membrane protein caveolin 3Membranes, vol. 11, no. 2, pp. 82-82H J Park; J Jang; K S Ryu; Jinhyuk Lee; S H Lee; H S Won; E H Kim; M D Seo; J H Kim
Article
7 2021

2021Article

Analysis of genomic pathogenesis according to the revised Bethesda guidelines and additional criteriaJournal of Cancer Research and Clinical Oncology, vol. 147, no. 1, pp. 117-128J C Kim; Jong-Hwan Kim; Y J Ha; Chan Wook Kim; K H Tak; Y S Yoon; Y H Kwon; S A Roh; D H Cho; Seon-Kyu Kim, et al.
Article
8 2021

2021Article

Discovery of natural inhibitors of cholinesterases from Hydrangea: in vitro and in silico approachesNutrients, vol. 13, no. 1, pp. 254-254J Hwang; K Youn; Gyutae Lim; Jinhyuk Lee; D H Kim; M Jun
Article
9 2021

2021Article

Identifying genome-wide off-target sites of CRISPR RNA-guided nucleases and deaminases with Digenome-seqNature Protocols, vol. 16, no. 2, pp. 1170-1192Daesik Kim; B C Kang; J S Kim
Article
10 2021

2021Article

STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse modelOncology Reports, vol. 45, no. 4, pp. 42-42Dong Hyuck Bae; Hee Jin Kim; Byoung Ha Yoon; Jong Lyul ParkMirang KimSeon-Kyu KimSeon-Young Kim; S I Lee; K S Song; Yong Sung Kim
Article
11 2021

2021Article

8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generationPhytotherapy Research, vol. 35, pp. 1508-1520Yujin Lee; Jiyeon Choi; Yae Jin Yoon; Yugyeong Sim; Hyung Won RyuSei-Ryang OhDoo-Young Kim; Jihyun Hwang; Seung-Wook ChiDong Cho Han, et al.
Article
12 2021

2021Article

The mitochondrial genome of hydrothermal vent barnacle Eochionelasmus coreana (Cirripedia: Thoracica) from the Indian OceanMitochondrial DNA Part B-Resources, vol. 6, no. 3, pp. 710-712Won Kyung Lee; B K K Chan; S J Ju; D Kim; Se-Joo Kim
Article
13 2021

2021Article

Diversity and characterization of bacterial communities of five co?occurring species at a hydrothermal vent on the Tonga ArcEcology and Evolution, vol. 11, pp. 4481-4493Won Kyung Lee; S K Juniper; M Perez; S J Ju; Se-Joo Kim
Article
14 2021

2021Article

Evaluation of the uninjured anterior talofibular ligament by ultrasound for assessing generalized joint hypermobilityFoot and Ankle Surgery, vol. 27, pp. 256-262J H Song; C Kang; Namshin Kim; J W Yi; G S Lee; M G Jang; T H Kim
Article
15 2021

2021Article

Targeting HSF1 as a therapeutic strategy for multiple mechanisms of EGFR inhibitor resistance in EGFR mutant non-small-cell lung cancer = 활성 EGFR 발현 비소세포 폐암의 EGFR 표적항암제에 대한 다중 내성 치료표적으로의 HSF1Cancers, vol. 13, pp. 2987-2987Sangah Lee; JiYae Jung; Yu-Jin LeeSeon-Kyu KimJung Ae KimBo Kyung KimKyung Chan ParkByoung-Mog KwonDong Cho Han
Article
16 2020

2020Article

Genome-wide association and epistatic interactions of flowering time in soybean cultivarPLoS One, vol. 15, pp. e0228114-e0228114Kyoung Hyoun Kim; Jae-Yoon Kim; Won-Jun Lim; Seongmun Jeong; Ho-Yeon Lee; Youngbum Cho; J K Moon; Namshin Kim
Article
17 2020

2020Article

A novel heterozygous missense variant (c.667G>T;p.Gly223Cys) in USH1C that interferes with cadherin-related 23 and harmonin interaction causes autosomal dominant nonsyndromic hearing lossAnnals of Laboratory Medicine, vol. 40, no. 3, pp. 224-231J S Song; A Bahloul; C Petit; S J Kim; I J Moon; Jinhyuk Lee; C S Ki
Article
18 2020

2020Article

Genomic signature of the standardized uptake value in 18F-fluorodeoxyglucose positron emission tomography in breast cancerCancers, vol. 12, no. 2, pp. 497-497Seon-Kyu Kim; S G Ahn; J Y Mun; M S Jeong; S J Bae; J S Lee; J Jeong; S H Leem; In-Sun Chu
Article
19 2020

2020Article

ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5International Journal of Cancer, vol. 146, no. 12, pp. 3354-3368Eun Hye Seo; Hee Jin Kim; Jong-Hwan Kim; B Lim; Jong Lyul ParkSeon-Young Kim; S I Lee; H Y Jeong; K S Song; Yong Sung Kim
Article
20 2020

2020Article

Protein kinase A catalytic subunit is a molecular switch that promotes the pro-tumoral function of macrophagesCell Reports, vol. 31, no. 6, pp. 107643-107643Y R Na; J W Kwon; D Y Kim; H Chung; J Song; D Jung; H Quan; Daesik Kim; J S Kim; Y W Ju, et al.
Article
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