Genome Editing Research Center (유전자교정연구센터)201

연구분야

  • 유전자 교정 기술의 고도화 연구
    • CRISPR/Cas9 및 CRISPR/cpf1 유전자 교정 기술의 효율성 증대 연구
    • 줄기세포, 질병 및 노화 관련 유전자들의 표적 조절 시스템 구축
  • 당질 유전자 교정 기술을 이용한 인간모사 마우스모델 개발
    • 인간과 마우스의 당질 차이를 유발하는 당질 유전자 선정 및 이 유전자를 교정한 마우스모델 개발
    • 인간모사 마우스의 비임상 적합성 검증
  • 신규 유전자 교정 기술 개발
    • 제 4세대 유전자 교정 기술 개발 및 효능 검증
  • 동물형질전환기술을 이용한 질환모델마우스 개발
  • 암발달과정에 있어서 항산화효소의 작용기전 연구
  • 무정형 단백질의 생물학적 활성 기전 및 질병 유발 기전 규명
  • 난치성 질환의 진단 및 치료를 위한 신규 유기 고분자/나노 화합물의 설계, 합성 및 응용
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Showing results 1 to 20 of 103

No. Year Title Type
1 2022

2022Article

Efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs delivered by adeno-associated virusNature Biotechnology, vol. 40, no. 1, pp. 94-102Doyon Kim; Jeongmi Lee; Subin Moon; Hyun Jung Chin; S Park; Y Lim; Daesik Kim; T Koo; Jeong Heon KoYong-Sam Kim
Article
2 2022

2022Article

Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and impairs muscle function in vivoScientific Reports, vol. 12, pp. 3216-3216M Oh; Dae In Ha; C Son; Jeong Gu Kang; H Hwang; Su Bin Moon; M Kim; Jihae Nam; Jung Soo Kim; S Y Song, et al.
Article
3 2022

2022Article

O-GlcNAcylation: an emerging protein modification regulating the hippo pathwayCancers, vol. 14, no. 12, pp. 3013-3013E Kim; Jeong Gu Kang; E H Jho; W H Yang; J W Cho
Article
4 2022

2022Article

Editing of StSR4 by Cas9-RNPs confers resistance to Phytophthora infestans in potatoFrontiers in Plant Science, vol. 13, pp. 997888-997888Ki Beom Moon; Su-Jin Park; Ji-Sun Park; Hyo Jun Lee; Seung Yong Shin; S M Lee; G J Choi; S G Kim; Hye Sun ChoJae Heung Jeon, et al.
Article
5 2022

2022Article

Hypercompact adenine base editors based on transposase B guided by engineered RNANature Chemical Biology, vol. 18, no. 9, pp. 1005-1013D Y Kim; Y Chung; Yujin Lee; Dongmin Jeong; Kwang Hyun Park; Hyun Jung Chin; Jeong Mi Lee; S Park; S Ko; Jeong Heon Ko, et al.
Article
6 2022

2022Article

SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 ExpressionMolecules and Cells, vol. 45, no. 10, pp. 718-728H Kim; J Lee; S Y Jung; H H Yun; Jeong Heon Ko; J H Lee
Article
7 2021

2021Article

One-step genotyping method in CRISPR based on short inner primer-assisted, tetra primer-paired amplificationsMolecular and Cellular Probes, vol. 55, pp. 101675-101675Nan Ee Lee; Dae In Ha; Jeong Heon KoYong-Sam Kim
Article
8 2021

2021Article

Detection of infectious viruses using CRISPR-Cas12-based assayBiosensors, vol. 11, no. 9, pp. 301-301C S Talwar; Kwang Hyun Park; Woo-Chan Ahn; Yong-Sam KimOh Seok Kwon; D Yong; Taejoon KangEuijeon Woo
Article
9 2021

2021Article

Depletion of ST6GALNACIII retards A549 non-small cell lung cancer cell proliferation by downregulating transferrin receptor protein 1 expressionBiochemical and Biophysical Research Communications, vol. 575, pp. 78-84S Y Jung; H K Lee; H Kim; S Kim; Jung Soo KimJeong Gu Kang; H J Kuh; J S Yoo; Jeong Heon Ko; J H Lee
Article
10 2020

2020Article

Machine learning classifies core and outer fucosylation of N-glycoproteins using mass spectrometryScientific Reports, vol. 10, pp. 318-318H Hwang; H K Jeong; H K Lee; G W Park; J Y Lee; S Y Lee; Y M Kang; H J An; Jeong Gu KangJeong Heon Ko, et al.
Article
11 2020

2020Article

Highly efficient and safe genome editing by CRISPR-Cas12a using CRISPR RNA with a ribosyl-2'-O-methylated uridinylate-rich 3'-overhang in mouse zygotesExperimental and Molecular Medicine, vol. 52, no. 11, pp. 1823-1830Dae In Ha; Jeongmi Lee; Nan Ee Lee; Daesik Kim; Jeong Heon KoYong-Sam Kim
Article
12 2020

2020Article

Unbiased investigation of specificities of prime editing systems in human cellsNucleic Acids Research, vol. 48, no. 18, pp. 10576-10589Do Yon Kim; Su Bin Moon; Jeong Heon KoYong Sam Kim; Daesik Kim
Article
13 2020

2020Article

Aglycosylated antibody-producing mice for aglycosylated antibody-lectin coupled immunoassay for the quantification of tumor markers (ALIQUAT)Communications Biology, vol. 3, pp. 636-636Nan Ee Lee; Sun Hee Kim; Dae Yeul Yu; Eui-jeon Woo; M I Kim; G S Seong; S M Lee; Jeong Heon KoYong Sam Kim
Article
14 2020

2020Article

O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activityProceedings of National Academy of Sciences of United States of America, vol. 117, no. 25, pp. 14259-14269E Kim; Jeong Gu Kang; M J Kang; J H Park; Y J Kim; T H Kweon; H W Lee; E H Jho; Y H Lee; S I Kim, et al.
Article
15 2020

2020Article

Selective identification of α-galactosyl epitopes in N-glycoproteins using characteristic fragment ions from higher-energy collisional dissociationAnalytical Chemistry, vol. 92, no. 19, pp. 13144-13154H K Lee; Dae In Ha; Jeong Gu Kang; G W Park; J Y Lee; K Cho; Su Bin Moon; J H Shin; Yong-Sam Kim; H J An, et al.
Article
16 2019

2019Article

Improving CRISPR genome editing by engineering guide RNAsTrends in Biotechnology, vol. 37, no. 8, pp. 870-881Su Bin Moon; Do Yon Kim; Jeong Heon Ko; J S Kim; Yong Sam Kim
Article
17 2019

2019Article

Regulation of gene expression by altered promoter methylation using a CRISPR/Cas9-mediated epigenetic editing systemScientific Reports, vol. 9, pp. 11960-11960Jeong Gu Kang; Jin Suk Park; Jeong Heon KoYong Sam Kim
Article
18 2019

2019Article

In vivo genome editing using the Cpf1 ortholog derived from Eubacterium eligensScientific Reports, vol. 9, pp. 13911-13911Woo-Chan Ahn; Kwang Hyun Park; I S Bak; H N Song; Yan An; Su-Jin Lee; M Jung; K W Yoo; Dae Yeul Yu; Yong Sam Kim, et al.
Article
19 2019

2019Article

Recent advances in the CRISPR genome editing tool setExperimental and Molecular Medicine, vol. 51, no. 11, pp. 130-130Su Bin Moon; Do Yon Kim; Jeong Heon KoYong Sam Kim
Article
20 2019

2019Article

Comprehensive profiling of surface gangliosides extracted from various cell lines by LC-MS/MSCells, vol. 8, no. 11, pp. 1323-1323J Lee; H Hwang; S Kim; J Hwang; J Yoon; D Yin; S I Choi; Y H Kim; Yong Sam Kim; H J An
Article
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