Natural Medicine Research Center (천연물의약전문연구단)921

연구분야

  • 국내/해외 식물자원의 식물추출물 라이브러리 구축
  • 만성염증질환(천식/COPD, atopy 등) 치료용 천연물소재 개발
  • 대사성질환(비만, 당뇨) 치료용 천연물소재 개발
  • 기능성 유전체학 및 단백체학에 근거한 천식/COPD 생체지표 개발
  • 천연물대사체를 이용한 약용자원의 원산지판별 및 표준화
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Showing results 1 to 20 of 673

No. Year Title Type
1 2021

2021Article

Biflavonoid-rich fraction from Daphne pseudomezereum var. koreana Hamaya exerts anti-inflammatory effect in an experimental animal model of allergic asthmaJournal of Ethnopharmacology, vol. 265, pp. 113386-113386Jae Won LeeHyung Won RyuDoo-Young KimOk-Kyoung KwonHyun Jae Jang; H J Kwon; S Y Kim; Su Ui Lee; Sung-Man Kim; Eun Sol Oh, et al.
Article
2 2021

2021Article

Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-κB activation and upregulating HO-1 expressionJournal of Ethnopharmacology, vol. 267, pp. 113523-113523Sung-Man Kim; Hyung Won RyuOk-Kyoung Kwon; Daseul Hwang; Min Gu Kim; Jae-Hong Min; Z Zhang; Soo Yong KimJin Hyub PaikSei-Ryang Oh, et al.
Article
3 2021

2021Article

Transforming growth factor β inhibits MUC5AC expression by Smad3/HDAC2 complex formation and NF-κB deacetylation at K310 in NCI-H292 cellsMolecules and Cells, vol. 44, no. 1, pp. 38-49Su Ui LeeMun-Ock Kim; Myung Ji Kang; Eun Sol Oh; H Ro; Ro-Woon Lee; Yu Na Song; Sunin Jung; Jae-Won LeeSoo Yun Lee, et al.
Article
4 2021

2021Article

Rapid identification of isoprenylated flavonoids constituents with inhibitory activity on bacterial neuraminidase from root barks of paper mulberry (Broussonetia papyrifera)International Journal of Biological Macromolecules, vol. 174, pp. 61-68Mi Hyeon Park; Sunin Jung; H J Yuk; Hyun-Jae Jang; Won Jun Kim; Doo-Young Kim; GyuTae Lim; Jinhyuk LeeSei-Ryang OhSu Ui Lee, et al.
Article
5 2021

2021Article

A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis by modulating immune balance and skin barrier function in a 1-chloro-2,4-dinitrobenzene-induced murine modelPhytomedicine, vol. 82, pp. 153407-153407Y S Lee; Hyung Won Ryu; W K Yang; Mi Hyeon Park; Y C Park; Doo-Young Kim; H J Kwon; S Y Kim; Sei-Ryang Oh; S H Kim
Article
6 2021

2021Article

Dutomycin induces autophagy and apoptosis by targeting the serine protease inhibitor SERPINB6ACS Chemical Biology, vol. 16, no. 2, pp. 360-370Mina Jang; S Hara; Gun-Hee Kim; Seung Min Kim; Sangkeun Son; Mincheol Kwon; In Ja Ryoo; H Seo; M J Kim; N D Kim, et al.
Article
7 2021

2021Article

Tilianin attenuates HDM-induced allergic asthma by suppressing Th2-immune responses via downregulation of IRF4 in dendritic cellsPhytomedicine, vol. 80, pp. 153392-153392Soo-Jin Park; Kiram Lee; Min Ah Kang; Tae-Hyoun Kim; Hyun Jae JangHyung Won RyuSei-Ryang OhHyun-Jun Lee
Article
8 2021

2021Article

Polyacetylene (9Z,16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid in Dendropanax morbifera leavesFood Bioscience, vol. 40, pp. 100878-100878Mun-Ock Kim; Myung Ji Kang; Su Ui LeeDoo-Young KimHyun-Jae Jang; Ju Hyeon An; Hyun Sun LeeHyung Won RyuSei-Ryang Oh
Article
9 2021

2021Article

A pipecolic acid-rich branched cyclic depsipeptide ulleungamide C from a Streptomyces species induces G0/G1 cell cycle arrest in promyelocytic leukemia cellsJournal of Antibiotics, vol. 74, no. 3, pp. 181-189Sangkeun Son; Mina Jang; Byeongsan Lee; Jun-Pil JangYoung-Soo HongBo Yeon KimSung-Kyun KoJae-Hyuk JangJong Seog Ahn
Article
10 2021

2021Article

8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generationPhytotherapy Research, vol. 35, pp. 1508-1520Yujin Lee; Jiyeon Choi; Yae Jin Yoon; Yugyeong Sim; Hyung Won RyuSei-Ryang OhDoo-Young Kim; Jihyun Hwang; Seung-Wook ChiDong Cho Han, et al.
Article
11 2021

2021Article

Diacylglycerol acyltransferase inhibitory new meroterpenes from the seeds of Psoralea corylifolia, and their structure-activity relationship studyFitoterapia, vol. 151, pp. 104881-104881M X Xiu; Y M Zhao; Y Zhang; D X Xiong; D Wang; Hyun Sun Lee; L Cui
Article
12 2021

2021Article

The role of macrophages in the development of acute and chronic inflammatory lung diseasesCells, vol. 10, no. 4, pp. 897-897Jae-Won Lee; W Chun; H J Lee; Jae-Hong Min; Seong Man Kim; Ji-Yun Seo; Kyung Seop AhnSei-Ryang Oh
Article
13 2021

2021Article

3,4,5-Trihydroxycinnamic acid exerts anti-inflammatory effects on TNF-α/IFN-γ-stimulated HaCaT cellsMolecular Medicine Reports, vol. 24, no. 1, pp. 509-509Ji Won Park; Jae-Hoon Oh; Daseul Hwang; Seong Man Kim; Jae-Hong Min; Ji-Yun Seo; W Chun; H J Lee; Sei-Ryang OhJae-Won Lee, et al.
Article
14 2020

2020Article

Acacetin enhances glucose uptake through insulin-independent GLUT4 translocation in L6 myotubesPhytomedicine, vol. 68, pp. 153178-153178Eun-Bin Kwon; Myung Ji Kang; Hyung Won Ryu; Seokhyen Lee; Jae Won Lee; M K Lee; Hyun Sun LeeSu Ui LeeSei-Ryang OhMun-Ock Kim
Article
15 2020

2020Article

Catenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora speciesBioorganic & Medicinal Chemistry Letters, vol. 30, no. 7, pp. 127005-127005Sangkeun Son; Mina Jang; Byeongsan Lee; Jung-Sook LeeYoung-Soo HongBo Yeon KimSung-Kyun KoJae-Hyuk JangJong Seog Ahn
Article
16 2020

2020Article

Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylationBone, vol. 131, pp. 115153-115153Hye-Min Kim; L He; Sangku Lee; Chanmi park; Dong Hyun Kim; Ho Jin Han; Junyeol Han; Joonsung HwangHyunjoo ChaKyung Ho Lee, et al.
Article
17 2020

2020Article

Methyl lucidone induces apoptosis and G2/M phase arrest via the PI3K/Akt/NF-κB pathway in ovarian cancer cellsPharmaceutical Biology, vol. 58, no. 1, pp. 51-59J H Yoon; J W Shin; T H Pham; Y J Choi; Hyung Won RyuSei-Ryang Oh; J W Oh; D Y Yoon
Article
18 2020

2020Article

Antiangiogenic potentials of ahpatinins obtained from a Streptomyces speciesOncology Reports, vol. 43, no. 2, pp. 625-634Jang Mi Han; Jun-Pil JangJae-Hyuk JangJong Seog Ahn; H J Jung
Article
19 2020

2020Article

Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screeningJournal of Antibiotics, vol. 73, pp. 184-188Byeongsan Lee; Sangkeun Son; Jae Kyoung Lee; Mina Jang; Kyung Taek Heo; Sung-Kyun KoDong Jin ParkChan Sun ParkChang-Jin KimJong Seog Ahn, et al.
Article
20 2020

2020Article

mpCRISTAR: multiple plasmid approach for CRISPR/Cas9 and TAR-mediated multiplexed refactoring of natural product biosynthetic gene clustersACS Synthetic Biology, vol. 9, no. 1, pp. 175-180H Kim; C H Ji; H W Je; Jong-Pyung Kim; H S Kang
Article
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