Anticancer Agent Research Center (항암물질연구센터)690

연구분야

  • 항암 및 암전이 후보물질 발굴
    • 암세포 특이대사 조절 항암 유효물질 발굴
    • 암세포 이동 및 전이기작 규명과 암전이 억제제 발굴
  • 대사산물의 화학생물학적 타겟 규명
    • 미생물 신규대사산물의 세포내 작용기작 분석
    • 화학생물학적 기법을 통한 세포내 신규 타겟분자 발굴
  • 세포내 소기관 물질이동 조절물질 발굴
    • Autophagy 및 세포내 소기관 기능 조절 생리활성 물질의 개발
  • 단백질분해 기반 발암 제어기술 개발
    • N-end rule pathway에 의한 단백질분해 경로를 분석하여 새로운 항암타겟 및 항암물질 발굴
  • 미생물 기능대사체 공학
    • 미생물의 생리활성 2차대사산물의 발굴과 라이브러리 구축
    • 미생물 합성생물공학 및 대사제어 기술을 통해 생리활성 2차대사체 발굴
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Showing results 1 to 20 of 615

No. Year Title Type
1 2021

2021Article

Total synthesis of agastaquinone, a diterpenoid quinone isolated from Agastache rugosaSynthetic Communications, vol. 51, no. 1, pp. 134-138Sangku Lee; Jisu Yoo; J K Jung; J N Kim; M S Yoon
Article
2 2021

2021Article

Collapsin response mediator protein 4 enhances the radiosensitivity of colon cancer cells through calcium-mediated cell signalingOncology Reports, vol. 45, no. 4, pp. 6-6Sang Yoon Park; Jong-Tae Kim; Eun Sun Park; Yo Sep Hwang; Hyang Ran Yoon; Kyung Eun Baek; Haiyoung JungSuk Ran YoonBo Yeon KimHee Jun Cho, et al.
Article
3 2021

2021Article

Dutomycin induces autophagy and apoptosis by targeting the serine protease inhibitor SERPINB6ACS Chemical Biology, vol. 16, no. 2, pp. 360-370Mina Jang; S Hara; Gun-Hee Kim; Seung Min Kim; Sangkeun Son; Mincheol Kwon; In Ja Ryoo; H Seo; M J Kim; N D Kim, et al.
Article
4 2021

2021Article

A pipecolic acid-rich branched cyclic depsipeptide ulleungamide C from a Streptomyces species induces G0/G1 cell cycle arrest in promyelocytic leukemia cellsJournal of Antibiotics, vol. 74, no. 3, pp. 181-189Sangkeun Son; Mina Jang; Byeongsan Lee; Jun-Pil JangYoung-Soo HongBo Yeon KimSung-Kyun KoJae-Hyuk JangJong Seog Ahn
Article
5 2021

2021Article

P62-induced cancer-associated fibroblast activation via the Nrf2-ATF6 pathway promotes lung tumorigenesisCancers, vol. 13, no. 4, pp. 864-864Ji In Kang; Dong Hyun Kim; K W Sung; S M Shim; Hyunjoo Cha-MolstadNak-Kyun SoungKyung Ho LeeJoonsung HwangHee Gu Lee; Y T Kwon, et al.
Article
6 2021

2021Article

Synthesis of spirooxindoles bearing 1,3-oxathiolane-2-thione moiety from isatin-derived propargylic alcoholsBulletin of Korean Chemical Society, vol. 42, pp. 429-434J N Kim; Sangku Lee
Article
7 2021

2021Article

Enzymatic characterization and comparison of two steroid hydroxylases CYP154C3-1 and CYP154C3-2 from Streptomyces speciesJournal of Microbiology and Biotechnology, vol. 31, no. 3, pp. 464-474P Subedi; K H Kim; Young-Soo Hong; J H Lee; T J Oh
Article
8 2021

2021Article

Altered endocytosis in cellular senescenceAgeing Research Reviews, vol. 68, pp. 101332-101332E Y Shin; Nak-Kyun Soung; M A Schwartz; E G Kim
Article
9 2021

2021Article

Jejucarbazoles A-C, Carbazole Glycosides with Indoleamine 2,3-dioxygenase 1 inhibitory activity from Streptomyces sp. KCB15JA151RSC Advances, vol. 11, pp. 19805-19812Gil Su Kim; Jun-Pil Jang; Mincheol Kwon; Tae Hoon Oh; Kyung Taek Heo; Byeongsan Lee; Jung-Sook LeeSung-Kyun KoYoung-Soo HongJong Seog Ahn, et al.
Article
10 2021

2021Article

R-catcher, a potent molecular tool to unveil the arginylomeCellular and Molecular Life Sciences, vol. 78, no. 7, pp. 3725-3741Taewook Seo; Jihyo Kim; Ho Chul Shin; Jung Gi Kim; S Ju; L Nawale; Goeun Han; Hye Seon Lee; G Bang; J Y Kim, et al.
Article
11 2021

2021Article

Identification of molecules from coffee silverskin that suppresses myostatin activity and improves muscle mass and strength in miceMolecules, vol. 26, no. 9, pp. 2676-2676J H Kim; J H Kim; Jun-Pil JangJae-Hyuk Jang; D H Jin; Y S Kim; H J Jin
Article
12 2021

2021Article

Wnt5a-induced docking of Plk1 on HEF1 promotes HEF1 translocation and tumorigenesisGenes & Genomics, vol. 43, no. 5, pp. 567-575Jeong Ah Hwang; Ji Eun Yu; Sun Ok Kim; Dong Hyun Kim; K S Cho; Kyung Ho Lee
Article
13 2020

2020Article

Regulation of reticulophagy by the N-degron pathwayAutophagy, vol. 16, no. 2, pp. 373-375J H Ji; H Y Kim; A J Heo; M J Lee; D Y Park; Dong Hyun Kim; Bo Yeon Kim; Y T Kwon
Article
14 2020

2020Article

Catenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora speciesBioorganic & Medicinal Chemistry Letters, vol. 30, no. 7, pp. 127005-127005Sangkeun Son; Mina Jang; Byeongsan Lee; Jung-Sook LeeYoung-Soo HongBo Yeon KimSung-Kyun KoJae-Hyuk JangJong Seog Ahn
Article
15 2020

2020Article

Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylationBone, vol. 131, pp. 115153-115153Hye-Min Kim; L He; Sangku Lee; Chanmi park; Dong Hyun Kim; Ho Jin Han; Junyeol Han; Joonsung HwangHyunjoo ChaKyung Ho Lee, et al.
Article
16 2020

2020Article

Antiangiogenic potentials of ahpatinins obtained from a Streptomyces speciesOncology Reports, vol. 43, no. 2, pp. 625-634Jang Mi Han; Jun-Pil JangJae-Hyuk JangJong Seog Ahn; H J Jung
Article
17 2020

2020Article

Wnt3a stimulation promotes primary ciliogenesis through beta-catenin phosphorylation-induced reorganization of centriolar satellitesCell Reports, vol. 30, pp. 1447-1462Mi-Lang Kyun; Sun Ok Kim; Hee Gu Lee; J A Hwang; Joonsung HwangNak Kyun SoungHyunjoo ChaSangku Lee; Y T Kwon; Bo Yeon Kim, et al.
Article
18 2020

2020Article

Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screeningJournal of Antibiotics, vol. 73, pp. 184-188Byeongsan Lee; Sangkeun Son; Jae Kyoung Lee; Mina Jang; Kyung Taek Heo; Sung-Kyun KoDong Jin ParkChan Sun ParkChang-Jin KimJong Seog Ahn, et al.
Article
19 2020

2020Article

Xyloneside A: a new glycosylated incisterol derivative from Xylaria sp. FB = Xyloneside A: Xylaria sp.의 새로운 glycosylated Incisterol 유도체 FBChembiochem, vol. 21, no. 16, pp. 2253-2258S R Lee; N B Kreuzenbeck; Mina Jang; Taehoon Oh; Sung-Kyun KoJong Seog Ahn; C Beemelmanns; K H Kim
Article
20 2020

2020Article

Kushenol E inhibits autophagy and impairs lysosomal positioning via VCP/p97 inhibitionBiochemical Pharmacology, vol. 175, pp. 113861-113861Mincheol Kwon; Mina Jang; Gun-Hee Kim; Taehoon Oh; In Ja RyooHyung Won RyuSei-Ryang OhBo Yeon KimJae-Hyuk JangSung-Kyun Ko, et al.
Article
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