Functional Biomaterial Research Center (기능성바이오소재연구센터)331

연구분야

  • 천연소재를 활용한 감염성 질병 제어용 소재 개발
    • 감염성 질병 제어용 타깃 인자를 활용한 생리활성물질의 탐색시스템 구축 및 활성 검증 연구
    • 스크리닝을 통한 바이오소재 확보 및 라이브러리 구축
    • 생리활성 후보 물질의 활성 조절 및 세포 기능 조절기전 구명 연구
    • 감염동물모델 확립을 통한 후보 활성물질의 안전성 및 효능 검증
  • 항바이러스 효과를 갖는 생리활성 저해물질의 효율적 탐색시스템 구축 및 스크리닝을 통한 바이오소재 확보 및 라이브러리 구축
    • ABSL-2/3 동물시설을 이용한 바이러스 감염동물모델 확립을 통해 후보물질의 안정성 및 효능검증
    • 숙주·바이러스간 상호작용 분석을 통한 후보 활성물질의 작용점 구명
    • 바이러스 이미징 시스템 구축을 통한 효율적인 안전성 및 효능검증
  • 천연소재를 이용한 염증제어 및 면역조절 소재의 개발
    • in vitro 시스템을 이용하여 활성소재의 면역세포 및 염증세포 조절효능 평가 및 기전연구
    • 면역질환 동물모델을 이용한 후보물질의 효능 검증 및 작용 기전연구
  • 유용생물소재 생산균주 확보 및 대량생산 공정개발
    • 유용생물소재용 미생물 균주의 개량
    • 발효식품용 미생물 균주의 개량
    • 미생물 유래 기능성 효소의 대량생산
    • 난분해성 농약분해 미생물 개발
  • 식물 및 식물세포배양 기반 식물백신 소재 및 유용물질 대량생산을 위한 분자농업 연구
    • 가축질병 제어용 식물백신 소재 및 유용 소재 개발
    • 식물세포배양을 통한 유용물질 생산 증진기술 개발
    • 바이오리액터를 활용한 유용 식물세포주 소재 대량생산기술 개발
    • 나고야의정서 대응 식물세포주 기반 산업계 대체 생물자원 개발
  • 식물 대사플럭스 조절 및 대사재설계를 통한 유용물질 생산 극대화
    • 오믹스 기반 식물 대사생합성 경로 탐색 및 대사조절기술 개발
    • 유전자 교정 기술접목을 통한 유용대사체 생산 극대화
    • 식물 스마트 세포 기반 생물전환을 통한 유용소재의 가치제고
    • NGS 기술을 이용한 주요 대사생합성 네트워크 및 유전체-대사체 조절 상관관계 규명
더보기

Showing results 1 to 20 of 250

No. Year Title Type
1 2021

2021Article

Evaluation of 13-week subchronic toxicity of Platycodon grandiflorus (Jacq.) A.DC. root extract in ratsJournal of Ethnopharmacology, vol. 267, pp. 113621-113621S B Cha; Y Li; J S Bae; S W Song; In Chul Lee; J C Kim
Article
2 2021

2021Article

Sargassum horneri ethanol extract ameliorates TNF-α/IFN-γ-induced inflammation in human keratinocytes and TPA-induced ear edema in miceFood Bioscience, vol. 39, pp. 100831-100831E J Han; H S Kim; Kyungsook Jung; K K A Sanjeewa; K H I N M Herath; W Lee; Y Jee; Y J Jeon; J Lee; T Kim, et al.
Article
3 2021

2021Article

Salmonella vaccine vector system for foot-and-mouth disease virus and evaluation of its efficacy with virus-like particles = 구제역 바이러스에 대한 살모넬라 백신 백터 시스템과 바이러스 유사입자에 대한 백신 효능 평가Vaccines, vol. 9, pp. 22-22Y Zhi; H J Ji; H Guo; J H Lim; E B Byun; Woo Sik Kim; H S Seo
Article
4 2021

2021Article

Native high-density lipoproteins (HDL) with higher paraoxonase exerts a potent antiviral effect against SARS-CoV-2 (COVID-19), while glycated HDL lost the antiviral activityAntioxidants, vol. 10, no. 2, pp. 209-209K H Cho; J R Kim; In Chul LeeHyung-Jun Kwon
Article
5 2021

2021Article

Bombyx batryticatus protein-rich extract induces maturation of dendritic cells and Th1 polarization: a potential immunological adjuvant for cancer vaccineMolecules, vol. 26, no. 2, pp. 476-476H Y Song; J M Han; E H Byun; Woo Sik Kim; H S Seo; E B Byun
Article
6 2021

2021Article

HMOC, a chrysin derivative, induces tolerogenic properties in lipopolysaccharide-stimulated dendritic cellsInternational Journal of Immunopharmacology, vol. 95, pp. 107523-107523H Y Song; Woo Sik Kim; J M Han; W Y Park; S T Lim; E B Byun
Article
7 2021

2021Article

Safety pharmacology of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG), a novel siRNA nanoparticle platformToxicology Reports, vol. 8, pp. 839-845T R Kim; H Y Kim; I H Kim; K C Kim; Y Ko; J H Park; S Yun; In Chul Lee; S H Kim; H O Park
Article
8 2021

2021Article

Alnus hirsuta (Spach) Rupr. attenuates airway inflammation and mucus overproduction in a murine model of ovalbumin-challenged asthmaFrontiers in Pharmacology, vol. 12, pp. 614442-614442Ba Wool Lee; Ji Hye Ha; Yeongseon Ji; Seong Hun Jeong; Ju Hong Kim; Jihye Lee; Ji Young ParkHyung-Jun KwonKyungsook Jung; J C Kim, et al.
Article
9 2021

2021Article

Chrysin derivative CM1 and exhibited anti-inflammatory action by upregulating toll-iInteracting protein expression in lipopolysaccharide-stimulated RAW264.7 macrophage cellsMolecules, vol. 26, no. 6, pp. 1532-1532E B Byun; H Y Song; Woo Sik Kim; J M Han; H S Seo; W Y Park; K Kim; E H Byun
Article
10 2021

2021Article

Immunoregulatory properties of a crude extraction fraction rich in polysaccharide from Chrysanthemum zawadskii Herbich var. latilobum and its potential role as a vaccine adjuvantInternational Immunopharmacology, vol. 95, pp. 107513-107513J M Han; H Y Song; H S Seo; E H Byun; S T Lim; Woo Sik Kim; E B Byun
Article
11 2021

2021Article

The metabolite profile in culture supernatant of Aster yomena callus and its anti-photoaging effect in skin cells exposed to UVBPlants-Basel, vol. 10, no. 4, pp. 659-659Woo Sik Kim; J H Seo; Jae In Lee; E S Ko; S M Cho; J R Kang; J H Jeong; Yu Jeong JeongCha Young Kim; J D Cha, et al.
Article
12 2021

2021Article

Comparative analysis of metabolite profiling of momordica charantia leaf and the anti-obesity effect through regulating lipid metabolismInternational Journal of Environmental Research and Public Health, vol. 18, no. 11, pp. 5584-5584M Fan; Jae In Lee; Young Bae Ryu; Y J Choi; Y Tang; M Oh; S H Moon; B Lee; E K Kim
Article
13 2020

2020Article

Spiraea prunifolia var. simpliciflora attenuates oxidative stress and inflammatory responses in a murine model of lipopolysaccharide-iInduced acute lung injury and TNF-α-stimulated NCI-H292 cellsAntioxidants, vol. 9, pp. 198-198Ba Wool Lee; Ji Hye Ha; Han-Gyo Shin; Seong Hun Jeong; Da-Bin Jeon; Ju-Hong Kim; Ji Young ParkHyung Jun KwonKyungsook JungWoo Song Lee, et al.
Article
14 2020

2020Article

Metabolomic analysis of Morus cultivar root extracts and their ameliorative effect on testosterone-induced prostate enlargement in Sprague-Dawley ratsInternational Journal of Molecular Sciences, vol. 21, no. 4, pp. 1435-1435Y J Choi; Jae In Lee; M Fan; Y Tang; E J Yoon; Young Bae Ryu; E K Kim
Article
15 2020

2020Article

4-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challengePhytotherapy Research, vol. 34, pp. 624-633J W Ko; Hyung Jun Kwon; C S Seo; S J Choi; N R Shin; S H Kim; Y H Kim; J C Kim; M S Kim; I S Shin
Article
16 2020

2020Article

Induced extracellular production of stilbenes in grapevine cell culture medium by elicitation with methyl jasmonate and steviosideBioresources and Bioprocessing, vol. 7, pp. 38-38Jeong Yu Jeong; Park Su Hyun; Sung Chul Park; Soyoung Kim; Tae Hee Kim; Jiyoung LeeSuk Weon KimYoung Bae RyuJae Cheol JeongCha Young Kim
Article
17 2020

2020Article

Pinus thunbergii PARL leaf protects against alcohol-induced liver disease by enhancing antioxidant defense mechanism in BALB/c miceJournal of Functional Foods, vol. 73, pp. 104116-104116M S Jeong; S Park; E J Han; S Y Park; M J Kim; Kyungsook Jung; S H Cho; S Y Kim; W J Yoon; G Ahn, et al.
Article
18 2020

2020Article

Oleanolic acid acetate alleviates symptoms of experimental autoimmune encephalomyelitis in mice by regulating Toll-like receptor 2 signalingFrontiers in Pharmacology, vol. 11, pp. 556391-556391M Kim; Soyoung Lee; HyungJin Lim; Jihye Lee; Ji Young ParkHyung Jun KwonIn Chul LeeYoung Bae Ryu; J Kim; T Shin, et al.
Article
19 2020

2020Article

The synergistic effect of co-treatment of methyl jasmonate and cyclodextrins on pterocarpan production in Sophora flavescens cell culturesInternational Journal of Molecular Sciences, vol. 21, no. 11, pp. 3944-3944Soyoung Kim; Yu Jeong Jeong; Su Hyun Park; Sung Chul Park; Saet Buyl Lee; Jiyoung LeeSuk Weon Kim; B K Ha; Hyun Soon KimHyeran Kim, et al.
Article
20 2020

2020Article

Lindera obtusiloba attenuates oxidative stress and airway inflammation in a murine model of ovalbumin-challenged asthmaAntioxidants, vol. 9, no. 7, pp. 563-563Ba Wool Lee; Ji Hye Ha; Han Gyo Shin; S H Jeong; Ju Hong Kim; Jihye Lee; Ji Young ParkHyung Jun KwonKyungsook JungWoo Song Lee, et al.
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