Functional Biomaterial Research Center (기능성바이오소재연구센터)675

연구분야

  • 천연소재를 활용한 감염성 질병 제어용 소재 개발
    • 감염성 질병 제어용 타깃 인자를 활용한 생리활성물질의 탐색시스템 구축 및 활성 검증 연구
    • 스크리닝을 통한 바이오소재 확보 및 라이브러리 구축
    • 생리활성 후보 물질의 활성 조절 및 세포 기능 조절기전 구명 연구
    • 감염동물모델 확립을 통한 후보 활성물질의 안전성 및 효능 검증
  • 항바이러스 효과를 갖는 생리활성 저해물질의 효율적 탐색시스템 구축 및 스크리닝을 통한 바이오소재 확보 및 라이브러리 구축
    • ABSL-2/3 동물시설을 이용한 바이러스 감염동물모델 확립을 통해 후보물질의 안정성 및 효능검증
    • 숙주·바이러스간 상호작용 분석을 통한 후보 활성물질의 작용점 구명
    • 바이러스 이미징 시스템 구축을 통한 효율적인 안전성 및 효능검증
  • 천연소재를 이용한 염증제어 및 면역조절 소재의 개발
    • in vitro 시스템을 이용하여 활성소재의 면역세포 및 염증세포 조절효능 평가 및 기전연구
    • 면역질환 동물모델을 이용한 후보물질의 효능 검증 및 작용 기전연구
  • 유용생물소재 생산균주 확보 및 대량생산 공정개발
    • 유용생물소재용 미생물 균주의 개량
    • 발효식품용 미생물 균주의 개량
    • 미생물 유래 기능성 효소의 대량생산
    • 난분해성 농약분해 미생물 개발
  • 식물 및 식물세포배양 기반 식물백신 소재 및 유용물질 대량생산을 위한 분자농업 연구
    • 가축질병 제어용 식물백신 소재 및 유용 소재 개발
    • 식물세포배양을 통한 유용물질 생산 증진기술 개발
    • 바이오리액터를 활용한 유용 식물세포주 소재 대량생산기술 개발
    • 나고야의정서 대응 식물세포주 기반 산업계 대체 생물자원 개발
  • 식물 대사플럭스 조절 및 대사재설계를 통한 유용물질 생산 극대화
    • 오믹스 기반 식물 대사생합성 경로 탐색 및 대사조절기술 개발
    • 유전자 교정 기술접목을 통한 유용대사체 생산 극대화
    • 식물 스마트 세포 기반 생물전환을 통한 유용소재의 가치제고
    • NGS 기술을 이용한 주요 대사생합성 네트워크 및 유전체-대사체 조절 상관관계 규명
더보기

Showing results 1 to 20 of 400

No. Year Title Type
1 2022

2022Article

Inhibitory effects of euscaphic acid in the atopic dermatitis model by reducing skin inflammation and intense pruritusInflammation, vol. 45, no. 4, pp. 1680-1691N H Jeong; Soyoung Lee; Y A Choi; K S Song; S H Kim
Article
2 2022

2022Article

Hot water extract of Sasa borealis (Hack.) Makino & Shibata abate hydrogen peroxide-induced oxidative stress and apoptosis in kidney epithelial cellsAntioxidants, vol. 11, no. 5, pp. 1013-1013I P S Fernando; K G I S Kirindage; A M K Jayasinghe; E J Han; M K H M Dias; K P Kang; S I Moon; T S Shin; A Ma; Kyungsook Jung, et al.
Article
3 2022

2022Article

Characterization of a lactic acid bacterium-derived β-glucosidase for the production of rubusoside from steviosideEnzyme and Microbial Technology, vol. 153, pp. 109939-109939J A Ko; S Y Kim; H S Ahn; J G Go; Young Bae RyuWoo Song Lee; Y J Wee; J S Park; D Kim; Y M Kim
Article
4 2022

2022Article

Lipocalin2 as a potential antibacterial drug against Acinetobacter baumannii infectionJournal of Microbiology, vol. 60, no. 4, pp. 444-449D Lim; Su-Jin Park; H Y Kim; M Shin; M Song
Article
5 2022

2022Article

Osteopontin is a biomarker for early autoimmune uveoretinitisNeural Regeneration Research, vol. 17, no. 7, pp. 1604-1608J Kim; M Ahn; Y Choi; J Chun; Kyungsook Jung; A Tanaka; H Matsuda; T Shin
Article
6 2022

2022Article

Highly efficient bioconversion of trans-resveratrol to δ-viniferin using conditioned medium of grapevine callus suspension culturesInternational Journal of Molecular Sciences, vol. 23, no. 8, pp. 4403-4403Su Hyun Park; Yu Jeong Jeong; Sung Chul Park; Soyoung Kim; Yong Goo Kim; Gilok Shin; Hyung Jae JeongYoung Bae RyuJiyoung Lee; O R Lee, et al.
Article
7 2022

2022Article

Surface-enhanced Raman scattering-based immunoassay for severe acute respiratory syndrome coronavirus 2Biosensors & Bioelectronics, vol. 202, pp. 114008-114008Hyunjung Cha; Hyeran Kim; Y Joung; Hyunju Kang; Jeong Moon; Hyowon Jang; S Park; Hyung-Jun KwonIn Chul Lee; S Kim, et al.
Article
8 2022

2022Article

Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targetsAnatomy & Cell Biology, vol. 55, no. 1, pp. 20-27J Kim; J Chun; M Ahn; Kyungsook Jung; C Moon; T Shin
Article
9 2022

2022Article

Anti-obesity and anti-hyperglycemic effects of Meretrix lusoria protamex hydrolysate in ob/ob miceInternational Journal of Molecular Sciences, vol. 23, no. 7, pp. 4015-4015M J Kim; R Chilakala; H G Jo; Seung Jae Lee; D S Lee; S H Cheong
Article
10 2022

2022Article

Effect of Portulaca Oleracea L. extract on functional constipation: a randomized, double-blind, placebo-controlled trialSaudi Journal of Gastroenterology, vol. 28, no. 4, pp. 296-303K B Bang; J H Choi; J H Park; S Lee; Mun Chual RhoSeung Woong LeeSoyoung Lee; J E Shin
Article
11 2022

2022Article

Smartphone-based SARS-CoV-2 and variants detection system using colorimetric DNAzyme reaction triggered by loop-mediated isothermal amplification (LAMP) with clustered regularly interspaced short palindromic repeats (CRISPR)ACS Nano, vol. 16, no. 7, pp. 11300-11314Jayeon Song; B Cha; Jeong Moon; Hyowon Jang; S Kim; J Jang; D Yong; Hyung-Jun KwonIn Chul LeeEun Kyung Lim, et al.
Article
12 2022

2022Article

Deinococcus radiodurans R1 lysate induces tolerogenic maturation in lipopolysaccharide-stimulated dendritic cells and protects dextran sulfate sodium-induced colitis in miceJournal of Microbiology and Biotechnology, vol. 32, no. 7, pp. 835-843H Y Song; J M Han; Woo Sik Kim; J H Lee; W Y Park; E B Byun; E H Byun
Article
13 2022

2022Article

Peroxiredoxin 5 protects HepG2 cells from ethyl β-carboline-3-carboxylate-induced cell death via ROS-dependent MAPK signalling pathwaysJournal of Cancer, vol. 13, no. 11, pp. 3258-3267D P Xie; Y X Gong; J Lee; E M Jeong; C X Ren; X Y Guo; Y H Han; Y D Cui; Seung Jae LeeTaeho Kwon, et al.
Article
14 2022

2022Article

Nuclear receptor estrogen-related receptor modulates antimicrobial peptide expression for host innate immunity in Tribolium castaneumInsect Biochemistry and Molecular Biology, vol. 148, pp. 103816-103816B Choi; W R Park; Y J Kim; S Mun; Su-Jin Park; J H Jeong; H S Choi; D K Kim
Article
15 2022

2022Article

Immunological effects of Aster yomena callus-derived extracellular vesicles as potential therapeutic agents against allergic asthmaCells, vol. 11, no. 18, pp. 2805-2805Woo Sik Kim; Ji Hye Ha; Seong Hun Jeong; Jae In Lee; Ba-Wool Lee; Yu Jeong JeongCha Young KimJi Young ParkYoung Bae RyuHyung-Jun Kwon, et al.
Article
16 2022

2022Article

Genotoxicity evaluation of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG), a novel siRNA nanoparticle for the treatment of fibrotic diseaseDrug and Chemical Toxicology, vol. 45, no. 5, pp. 2109-2115H Y Kim; T R Kim; S H Kim; I H Kim; Y Ko; S Yun; In Chul Lee; H O Park; J C Kim
Article
17 2022

2022Article

Regulatory effects of Lycium barbarum extract and isolated scopoletin on atopic dermatitis-like skin inflammationBiomed Research International, vol. 2022, pp. 2475699-2475699Seon Gyeong Bak; Hyung-Jin Lim; Yeong-Seon Won; Soyoung Lee; S H Cheong; S J Lee; E Y Bae; Seung Woong LeeSeung Jae LeeMun Chual Rho
Article
18 2021

2021Article

Native high-density lipoproteins (HDL) with higher paraoxonase exerts a potent antiviral effect against SARS-CoV-2 (COVID-19), while glycated HDL lost the antiviral activityAntioxidants, vol. 10, no. 2, pp. 209-209K H Cho; J R Kim; In Chul LeeHyung-Jun Kwon
Article
19 2021

2021Article

Alnus hirsuta (Spach) Rupr. attenuates airway inflammation and mucus overproduction in a murine model of ovalbumin-challenged asthmaFrontiers in Pharmacology, vol. 12, pp. 614442-614442Ba Wool Lee; Ji Hye Ha; Yeongseon Ji; Seong Hun Jeong; Ju Hong Kim; Jihye Lee; Ji Young ParkHyung-Jun KwonKyungsook Jung; J C Kim, et al.
Article
20 2021

2021Article

Immunoregulatory properties of a crude extraction fraction rich in polysaccharide from Chrysanthemum zawadskii Herbich var. latilobum and its potential role as a vaccine adjuvantInternational Immunopharmacology, vol. 95, pp. 107513-107513J M Han; H Y Song; H S Seo; E H Byun; S T Lim; Woo Sik Kim; E B Byun
Article
1 2 3 4 5 6 7 8 9 10 11 20