Immunoregulatory materials Research Center (면역조절소재연구센터)275

연구분야

  • 유효 생리활성소재 탐색 및 확보
    • 생물소재의 효율적인 추출을 통한 분리·정제 및 구조 규명
    • 식품 미생물 유래 기능성 소재의 추출 및 유효화합물 확보
    • 기능성 단백질/펩타이드의 분리 및 아미노산 분석 공정 기술개발
  • 면역조절 생리활성소재의 효능 검증을 위한 시스템 구축 및 운용
    • 생물자원 유래 활성소재 탐색 및 활성화합물 라이브러리 구축
    • In vitro 활성 검색 시스템을 이용하여 소재의 면역 및 염증세포 조절효능 평가
    • In vivo 모델 구축 및 독성에 의한 안전성 평가
  • 농·생명자원 활용기술(작물보호/미생물 농약 소재 및 사료첨가제)개발
    • 후보물질의 가축 및 어패류 질병 제어용 사료첨가제 개발
    • 미생물을 활용한 농작물 피해 요인의 저해 및 사멸 화학물질 대체제 개발
    • 유해 생물자원으로부터 활성소재의 확보 및 응용 연구 수행
  • 기능성 생물소재의 산업화 연구
    • 안전성 평가 및 전임상 연구를 통한 반복 독성시험의 검증
    • 소재와 활성 관련 특허 기반의 기업 기술이전 시행
    • 질환 치료제 외 기능성 식품의 전략을 통한 레드오션 및 퍼플오션의 가능성 제시
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Showing results 1 to 20 of 196

No. Year Title Type
1 2021

2021Article

Hispidulin alleviates 2,4-dinitrochlorobenzene and house dust mite extract-induced atopic dermatitis-like skin inflammationBiomedicine & Pharmacotherapy, vol. 137, pp. 111359-111359J Kang; Soyoung Lee; N Kim; H Dhakal; Y A Choi; T K Kwon; D Khang; S H Kim
Article
2 2021

2021Article

Peroxiredoxin V silencing elevates susceptibility to doxorubicin-induced cell apoptosis via ROS-dependent mitochondrial dysfunction in AGS gastric cancer cellsAnticancer Research, vol. 41, no. 4, pp. 1831-1840Y J Jin; Y X Gong; Y Liu; D P Xie; C X Ren; Seung Jae Lee; H N Sun; Taeho Kwon; D Y Xu
Article
3 2020

2020Article

Prunus serrulata var. spontanea inhibits mast cell activation and mast cell-mediated anaphylaxisJournal of Ethnopharmacology, vol. 250, pp. 112484-112484M J Kim; Y A Choi; Soyoung Lee; J K Choi; Yeon Yong Kim; E N Kim; G S Jeong; T Y Shin; Y H Jang; S H Kim
Article
4 2020

2020Article

Polyozellin alleviates atopic dermatitis-like inflammatory and pruritic responses in activated keratinocytes and mast cellsBiomedicine & Pharmacotherapy, vol. 122, pp. 109743-109743N H Jeong; Soyoung Lee; J K Choi; Y A Choi; M J Kim; H S Lee; T Y Shin; Y H Jang; K S Song; S H Kim
Article
5 2020

2020Article

Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screeningJournal of Antibiotics, vol. 73, pp. 184-188Byeongsan Lee; Sangkeun Son; Jae Kyoung Lee; Mina Jang; Kyung Taek Heo; Sung-Kyun KoDong Jin ParkChan Sun ParkChang-Jin KimJong Seog Ahn, et al.
Article
6 2020

2020Article

Retrofractamide C derived from Piper longum alleviates xylene-induced mouse ear edema and inhibits phosphorylation of ERK and NF-κB in LPS-induced J774A.1Molecules, vol. 25, no. 18, pp. 4058-4058Hyung Jin Lim; Seon Gyeong Park; Eun Jae Park; S K Ku; Soyoung LeeSeung Woong Lee; K M Lee; Seung Jae LeeMun Chual Rho
Article
7 2020

2020Article

The suppressive effect of dabrafenib, a therapeutic agent for metastatic melanoma, in IgE-mediated allergic inflammationInternational Immunopharmacology, vol. 83, pp. 106398-106398Y A Choi; Soyoung Lee; J K Choi; B C Kang; M J Kim; H Dhakal; T K Kwon; D Khang; S H Kim
Article
8 2020

2020Article

Evaluation of nematicidal activity of Streptomyces yatensis KRA-28 against Meloidogyne incognitaJournal of Microbiology and Biotechnology, vol. 30, no. 5, pp. 700-707Eun Jae Park; Hyun Jae JangChan Sun ParkSeung Jae LeeSoyoung Lee; Kang Hoon Kim; B S Yun; Seung Woong LeeMun Chual Rho
Article
9 2020

2020Article

Changes in the content and bioavailability of onion quercetin and grape resveratrol during in vitro human digestionFoods, vol. 9, no. 6, pp. 694-694S Y Lee; Seung Jae Lee; D G Yim; S J Hur
Article
10 2020

2020Article

Acyclic triterpenoid isolated from Alpinia katsumadai alleviates formalin-induced chronic mouse paw inflammation by inhibiting the phosphorylation of ERK and NF-κBMolecules, vol. 25, pp. 3345-3345Hyung Jin Lim; Seon Gyeong Bak; Hee Ju Im; Seung Woong LeeSoyoung Lee; S K Ku; S I Park; Seung Jae LeeMun Chual Rho
Article
11 2020

2020Article

Anti-inflammatory activity of diterpenoids from Celastrus orbiculatus in lipopolysaccharide-stimulated RAW264.7 cellsJournal of Immunology Research, vol. 2020, pp. 7207354-7207354Hyun Jae Jang; Kang Hoon Kim; Eun Jae Park; Jeong A Kang; B S Yun; Seung Jae LeeChan Sun ParkSoyoung LeeSeung Woong LeeMun Chual Rho
Article
12 2020

2020Article

Oleanolic acid acetate alleviates symptoms of experimental autoimmune encephalomyelitis in mice by regulating Toll-like receptor 2 signalingFrontiers in Pharmacology, vol. 11, pp. 556391-556391M Kim; Soyoung Lee; HyungJin Lim; Jihye Lee; Ji Young ParkHyung Jun KwonIn Chul LeeYoung Bae Ryu; J Kim; T Shin, et al.
Article
13 2020

2020Article

Eleocharis kuroguwai Ohwi ameliorates LPS-mediated inflammation by suppressing MAPKs signaling = LPS로 유도된 염증 상태 내에서 MAPKs 세포신호 전달체계를 저해하는 올방개의 항염증 효과Journal of Life Science, vol. 30, no. 5, pp. 476-482Kang Hoon Kim; E Y Bae; H G Lim; M H Kim; T S Oh; Seung Woong Lee
Article
14 2020

2020Article

AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcεRI/TGF-β signaling pathwayPharmacological Research, vol. 159, pp. 105027-105027Yeon Yong Kim; Gayeong Hur; Seung Woong LeeSeung Jae LeeSoyoung Lee; S H Kim; Mun Chual Rho
Article
15 2020

2020Article

Bakuchicin attenuates atopic skin inflammationBiomedicine & Pharmacotherapy, vol. 129, pp. 110466-110466J S Lim; J Y Kim; Soyoung Lee; J K Choi; E N Kim; Y A Choi; Y H Jang; G S Jeong; S H Kim
Article
16 2020

2020Article

Hispidulin alleviates imiquimod-induced psoriasis-like skin inflammation by inhibiting splenic Th1/Th17 cell population and keratinocyte activationInternational Immunopharmacology, vol. 87, pp. 106767-106767N Kim; Soyoung Lee; J Kang; Y A Choi; B Lee; T K Kwon; Y H Jang; S H Kim
Article
17 2020

2020Article

Inhibitory effects of orientin in mast cell-mediated allergic inflammationPharmacological Reports, vol. 72, no. 4, pp. 1002-1010H Dhakal; Soyoung Lee; J K Choi; T K Kwon; D Khang; S H Kim
Article
18 2020

2020Article

Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritisFood Science & Nutrition, vol. 8, no. 12, pp. 6550-6556Hyung Jin Lim; S I Park; Seon Gyeong Bak; S H Cheong; Soyoung Lee; Y B Baek; C M Lee; K M Lee; Seung Woong LeeSeung Jae Lee, et al.
Article
19 2020

2020Article

Rugosic acid A, derived from Rosa rugosa Thunb., is novel inhibitory agent for NF-κB and IL-6/STAT3 axis in acute lung injury modelPhytotherapy Research, vol. 34, no. 12, pp. 3200-3210Kang Hoon Kim; Ye Ji Park; Hyun-Jae JangSeung Jae LeeSoyoung Lee; B S Yun; Seung Woong LeeMun Chual Rho
Article
20 2020

2020Article

Eudebeiolide B inhibits osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-induced NF-κB, c-Fos and calcium signalingPharmaceuticals, vol. 13, no. 12, pp. 468-468M H Kim; Hyung Jin Lim; Seong Gyeong Bak; Eun Jae Park; Hyun-Jae JangSeung Woong LeeSoyoung Lee; K M Lee; S H Cheong; Seung Jae Lee, et al.
Article
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