Immunotherapy Research Center (면역치료제연구센터)791

연구분야

  • HSC 기반 유전자 NK세포치료제 개발 (PL1,2)
    • 융복합 NK세포치료 임상연구
    • CAR-NK 세포 치료제 개발
    • 단일세포 영상 기반 면역세포 효능 검증
    • 주입형 나노하이드로겔 복합체 기반 면역세포 3차원 배양기술 개발
  • 항암제 활용 맞춤형 혼합 NK세포치료제 개발 (PL3)
    • 암세포에 있어서 NK 세포의 공격에 대한 감수성을 높이는 항암제 개발
    • 줄기세포 유래 NK 세포 항암기능향상 항암제 개발
    • 간암 맞춤형 전임상을 통한 NK 세포 치료제와의 혼합치료 최적화 기술 개발
  • 생체 이미징을 이용한 전임상 동물모델에서의 면역세포치료 효능 검증
    • 이식된 세포에 대한 동물모델에서의 실시간 생체영상 추적으로 NK 세포치료 유효성 검증
    • 생체영상 치료효과 모니터링을 통한 NK, NK-항암제, NK-항체 치료에 대한 치료 유효성 검증
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Showing results 181 to 200 of 554

No. Year Title Type
181 2015

2015Article

1-pamitoyl-2-linoleoyl-3-acetyl-rac-glycerol may reduce incidence of gemcitabine-induced neutropenia: A pilot case-controlled studyWorld Journal of Oncology, vol. 6, no. 4, pp. 410-415D Oh; M H Kim; T J Song; C J Cho; K Nam; M K Cho; J H Chun; K Jung; K P Kim; Jae Wha Kim
Article
182 2015

2015Article

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 bindingNature Cell Biology, vol. 17, no. 7, pp. 917-929Hyunjoo Cha; K S Sung; Joonsung Hwang; Kyeong A Kim; Ji-eun Yu; Y D Yoo; J M Jang; D H Han; M Molstad; Jung Gi Kim, et al.
Article
183 2015

2015Article

Proteomic and network analysis of proteins regulated by REX1 in human embryonic stem cellsProteomics, vol. 15, no. 13, pp. 2220-2229Mi Young Son; Jae Eun Kwak; Young-Dae Kim; Yee Sook Cho
Article
184 2015

2015Article

NMDA (n-mehtyl-d-aspartate) change expression level of transcription factors (Egr-1, c-jun, Junb, Fosb) mRMA in the cerebellum tissue of Balb/c mouse = NMDA 투여에 의한 transcription factor (Egr-1, c-jun, JunB, FosB)의 발현 변화 양상Journal of Life Science, vol. 25, no. 9, pp. 1043-1050J S Ha; Jae Wha Kim; J C Song
Article
185 2015

2015Article

Liposome-encapsulated CpG enhances antitumor activity accompanying the changing of lymphocyte populations in tumor via intratumoral administrationNucleic Acid Therapeutics, vol. 25, no. 2, pp. 95-102D H Kim; C Moon; S S Oh; S Park; J W Jeong; S Kim; Hee Gu Lee; H J Kwon; K D Kim
Article
186 2015

2015Article

Understanding of molecular mechanisms in natural killer cell therapyExperimental and Molecular Medicine, vol. 47, no. 2, pp. e141-e141Suk Ran YoonTae-Don Kim; In Pyo Choi
Article
187 2015

2015Article

Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinomaOncotarget, vol. 6, no. 9, pp. 7182-7194Sang Hyun Lee; I C Jeung; T W Park; Kungmin Lee; Dong Gwang Lee; Y L Cho; T S Lee; H J Na; Young-Jun ParkHee Gu Lee, et al.
Article
188 2015

2015Article

1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) modulates Th2 immunity through attenuation of IL-4 expressionImmune Network, vol. 15, no. 2, pp. 100-109S Y Yoon; Ho Bum Kang; Young Eun Go; Su Hyun Shin; Young-Jun Kim; K Y Sohn; Y H Han; S Chong; Jae Wha Kim
Article
189 2015

2015Article

NAD(P)H:Quinone oxidoreductase 1 activation reduces blood pressure through regulation of endothelial nitric oxide synthase acetylation in spontaneously hypertensive ratsAmerican Journal of Hypertension, vol. 28, no. 1, pp. 50-57Yong-Hoon KimJung Hwan HwangKyoung Shim KimJung Ran Noh; Gil Tae Gang; Youngwon SeoKi Hoan Nam; T H Kwak; Hee Gu LeeChul Ho Lee
Article
190 2015

2015Article

The effect of 4α,5α-epoxy-10α,14-dihydro-inuviscolide, a novel immunosuppressant isolated from Carpesium abrotanoides, on the cytokine profile in vitro and in vivoInternational Immunopharmacology, vol. 25, no. 1, pp. 121-129Young Eun Ko; Sei-Ryang Oh; Hyuk-Hwan Song; Hyung Won Ryu; S Y Ly; Jae Wha Kim
Article
191 2015

2015Article

Biochemical and molecular characterization of novel mutations in GLB1 and NEU1 in patient cells with lysosomal storage disordersBiochemical and Biophysical Research Communications, vol. 457, no. 4, pp. 554-560Jae Eun Kwak; Mi Young Son; Ye Seul Son; Myung Jin SonYee Sook Cho
Article
192 2015

2015Article

Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibodyBiomaterials, vol. 51, pp. 119-128Byngtae Hwang; Sang Hyun Lee; Jang Seong Kim; ji Hyun Moon; I C Jeung; Na Geum Lee; Jongjin Park; H J Hong; Young Lai Cho; Haiyoung Jung, et al.
Article
193 2015

2015Article

Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on immune functions in healthy adults in a randomized controlled trialImmune Network, vol. 15, no. 3, pp. 150-160H J Hwang; K Y Sohn; Y H Han; S Chong; S Y Yoon; Young-Jun Kim; Jinseoun Jeong; S H Kim; Jae Wha Kim
Article
194 2015

2015Article

Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS = iNOS의 억제를 통한 진세노사이드 Rg3의 역할Biochemical and Biophysical Research Communications, vol. 463, no. 4, pp. 1184-1189Sung Jin Yoon; Jun-Young Park; Song Choi; Jin-Bong Lee; Haiyoung JungTae-Don KimSuk Ran Yoon; In Pyo Choi; S Shim; Young-Jun Park
Article
195 2015

2015Article

Thymic stromal lymphopoietin induction is mediated by the major whey proteins α-lactalbumin and β-lactoglobulin through the NF-κB pathway in immune cellsJournal of Agricultural and Food Chemistry, vol. 63, no. 50, pp. 10803-10810Jae Min Yoo; Y W Park; S Y Yoon; J Y Son; S G Jeong; B Y Park; Jae Wha Kim; M S Nam
Article
196 2014

2014Article

Interleukin-32α modulates promyelocytic leukemia zinc finger gene activity by inhibiting protein kinase C?-dependent sumoylationInternational Journal of Biochemistry & Cell Biology, vol. 55, no. C, pp. 136-143Y S Park; J W Kang; D H Lee; M S Kim; Y Bak; Y Yang; Hee Gu Lee; J Hong; D Y Yoon
Article
197 2014

2014Article

Dephosphorylation of CCAAT/enhancer-binding protein β by protein phosphatase 2A containing B56δ is required at the early time of adipogenesisBiochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, vol. 1841, no. 11, pp. 1608-1618M Park; Y A Choi; Hee Gu Lee; K I Kim; J S Lim; M S Lee; K S Oh; Y Yang
Article
198 2014

2014Article

Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modificationOncotarget, vol. 5, no. 18, pp. 8765-8777Y S Park; J W Kang; D H Lee; M S Kim; Y Bak; Y Yang; Hee Gu Lee; J T Hong; D Y Yoon
Article
199 2014

2014Article

Genkwadaphnin induces IFN-γ via PKD1/NF-κB/STAT1 dependent pathway in NK-92 cellsPLoS One, vol. 9, no. 12, pp. e115146-e115146Ho Bum Kang; Kyung Seop AhnSei-Ryang OhJae Wha Kim
Article
200 2014

2014Article

Integrated mRNA-microRNA profiling of human NK cell differentiation identifies MiR-583 as a negative regulator of IL2Rγ expressionPLoS One, vol. 9, no. 10, pp. e108913-e108913Sohyun Yun; Su Ui Lee; J M Kim; Hyun-Jun Lee; Hae Young Song; Young Kyeung Kim; Haiyoung JungYoung-Jun ParkSuk Ran YoonSei-Ryang Oh, et al.
Article
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