Genome Editing Research Center (유전자교정연구센터)195

연구분야

  • 유전자 교정 기술의 고도화 연구
    • CRISPR/Cas9 및 CRISPR/cpf1 유전자 교정 기술의 효율성 증대 연구
    • 줄기세포, 질병 및 노화 관련 유전자들의 표적 조절 시스템 구축
  • 당질 유전자 교정 기술을 이용한 인간모사 마우스모델 개발
    • 인간과 마우스의 당질 차이를 유발하는 당질 유전자 선정 및 이 유전자를 교정한 마우스모델 개발
    • 인간모사 마우스의 비임상 적합성 검증
  • 신규 유전자 교정 기술 개발
    • 제 4세대 유전자 교정 기술 개발 및 효능 검증
  • 동물형질전환기술을 이용한 질환모델마우스 개발
  • 암발달과정에 있어서 항산화효소의 작용기전 연구
  • 무정형 단백질의 생물학적 활성 기전 및 질병 유발 기전 규명
  • 난치성 질환의 진단 및 치료를 위한 신규 유기 고분자/나노 화합물의 설계, 합성 및 응용
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Showing results 1 to 20 of 104

No. Year Title Type
1 1993

1993Article

Design and cloning of the gene for a novel insulin analogue,(B30-homoserine) human insulinArchives of Pharmacal Research, vol. 16, no. 4, pp. 271-275D H Nam; Jung Hun Koh; S Y Lee
Article
2 1994

1994Article

Metal affinity engineering of proinsulin carrying genetically attached (His)10-X-met affinity tail and removal of the tag by cyanogen bromideBioscience Biotechnology and Biochemistry, vol. 58, no. 9, pp. 1694-1699Jung Hun Koh; Wook Joon Chung; Suk Hoon Koh; Byoung Chul Park; Suk Tae Kwon; Chul Ho Kim; Dae Sil Lee
Article
3 1996

1996Article

Fermentation and purification of LacZ-fused single chain insulin precursor for (B3-homoserine) human insulinBiotechnology and Bioprocess Engineering, vol. 1, no. 1, pp. 9-12S Y Lee; Jeong Heon Ko; M H Choi; D H Nam
Article
4 1996

1996Article

Improved isolation of genomic DNA from mycobacteria in agarose plugs by rapid lysis with a combination of N-acetylglucosaminidase and lysozymeBiotechniques, vol. 20, no. 4, pp. 547-552Y K Choe; Y J Huh; Jong Hoon Park; J R Kim; J S Park; J C Song; Jung Hun Koh; Young Choon Lee; O Nashiru; Jin Koo Kim, et al.
Article
5 1996

1996Article

Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase IIIGene, vol. 170, no. 2, pp. 281-283Yeon Jeong Kim; Jong Hoon Park; Kyung Sook Kim; Ji Eun Chang; Jung Hun Koh; Myung Hee Kim; Dong Hyo Chung; Tai Wha Chung; In Seong Choe; Young Choon Lee, et al.
Article
6 1996

1996Article

Genomic heterogeneity in clinical strains of Mycobacterium tuberculosis, M. terrae complex, M. gordonae, M. avium-intracellulae complex and M. fortuitum by pulsed-field gel electrophoresisBMB Reports, vol. 29, no. 6, pp. 569-573Jeong Ran Kim; Bong Seok Kang; Jung Hun Koh; J S Park; S J Kim; G H Bai; T H Chung; K S Nam; Yong Kyung Choe; In Seong Choe, et al.
Article
7 1996

1996Article

Purification and characterization of a thermostable ADP-glucose pyrophosphorylase from Thermus caldophilus GK-24Biochemical Journal, vol. 319, pp. 977-983Jeong Heon Ko; Chul Ho Kim; Dae Sil Lee; Yu Sam Kim
Article
8 1996

1996Article

Purification and biochemical characterization of pullulanase type I from Thermus caldophilus GK-24FEMS Microbiology Letters, vol. 138, no. 2, pp. 147-152C H Kim; O Nashiru; Jung Hun Koh
Article
9 1996

1996Article

Purification and characterization of β-amylase from Bacillus polymyxa No. 26-1Journal of Food Science, vol. 61, no. 1, pp. 230-234C B Sohn; S M lee; M H Kim; Jung Hun Koh; K S Kim; J E Chang; Y K Ahn; C H Kim
Article
10 1996

1996Article

Biotransformation of uridine monophosphate(UMP) and glucose to uridine diphosphate-glucose(UDPG) by Candida saitoana KCTC7249 cellsApplied Biochemistry and Biotechnology, vol. 60, no. 1, pp. 41-48Jung Hun Koh; H S Shin; Y S Kim; Dae Sil Lee; C H Kim
Article
11 1996

1996Article

Molecular cloning and expression of human galβ1,3galNAc α2,3-Sialyltransferase(hST3Gal II)Biochemical and Biophysical Research Communications, vol. 228, no. 2, pp. 324-327Y J Kim; K S Kim; S H Kim; C H Kim; Jung Hun Koh; In Seong Choe; S Tsuji; Y C Lee
Article
12 1999

1999Article

High intracellular levels of uridinemonophosphate under nitrogen limited conditions enhance metabolic flux of curdlan synthesis in Agrobacterium speciesBiotechnology and Bioengineering, vol. 62, no. 3, pp. 317-323Mi Kyung Kim; In Young Lee; Jung Hun Koh; Y H Rhee; Young Hoon Park
Article
13 2002

2002Article

Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding β1-6 GlcNAc branchingJournal of Biological Chemistry, vol. 277, no. 19, pp. 16960-16967Shinji Ihara; Eiji Miyoshi; Jeong Heon Ko; Kohei Murata; Susumu Nakahara; Koichi Honke; Robert B Dickson; Chen Yong Lin; Naoyuki Taniguchi
Article
14 2002

2002Article

Enhanced expression of matrix metalloproteinase-9 by hepatitis B virus infection in liver cellsArchives of Biochemistry and Biophysics, vol. 408, no. 2, pp. 147-154T W Chung; S K Moon; Y C Lee; J G Kim; Jeong Heon Ko; C H Kim
Article
15 2003

2003Article

A water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterol-fed rabbitsInternational Immunopharmacology, vol. 3, no. 5, pp. 723-734B J Kim; Y K Kim; W H Park; Jung Hun Koh; Y C Lee; C H Kim
Article
16 2003

2003Article

Bombycis corpus extract (BCE) protects hippocampal neurons against excitatory amino acid-induced neurotoxicityImmunopharmacology and Immunotoxicology, vol. 25, no. 2, pp. 191-201B S Koo; H G An; S K Moon; Y C Lee; H M Kim; Jung Hun Koh; C H Kim
Article
17 2003

2003Article

Hepatitis B virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cellsCancer Research, vol. 63, no. 13, pp. 3453-3458T W Chung; Y C Lee; Jung Hun Koh; C H Kim
Article
18 2003

2003Article

Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampusJournal of Ethnopharmacology, vol. 87, no. 2, pp. 149-154Y K Kim; B S Koo; D J Gong; Y C Lee; Jung Hun Koh; C H Kim
Article
19 2003

2003Article

Analysis of plausible downstream target genes of Hoxc8 in F9 teratocarcinoma cells : Putative downstream target genes of Hoxc8Molecular Biology Reports, vol. 30, no. 3, pp. 141-148Y J Kwon; Jeong Heon Ko; B K Kim; M H Kim
Article
20 2003

2003Article

Genome mapping of an extreme thermophile, Thermus caldophilus GK24Genomics & Informatics, vol. 1, no. 1, pp. 50-54J H Park; Byoung Chul Park; Suk Hoon Koh; Joong Soo KimJeong Heon Ko; M H Yang; Yong Sung Kim; C H Kim; M H Kim; S T Kwon, et al.
Article
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