Genome Editing Research Center (유전자교정연구센터)195

연구분야

  • 유전자 교정 기술의 고도화 연구
    • CRISPR/Cas9 및 CRISPR/cpf1 유전자 교정 기술의 효율성 증대 연구
    • 줄기세포, 질병 및 노화 관련 유전자들의 표적 조절 시스템 구축
  • 당질 유전자 교정 기술을 이용한 인간모사 마우스모델 개발
    • 인간과 마우스의 당질 차이를 유발하는 당질 유전자 선정 및 이 유전자를 교정한 마우스모델 개발
    • 인간모사 마우스의 비임상 적합성 검증
  • 신규 유전자 교정 기술 개발
    • 제 4세대 유전자 교정 기술 개발 및 효능 검증
  • 동물형질전환기술을 이용한 질환모델마우스 개발
  • 암발달과정에 있어서 항산화효소의 작용기전 연구
  • 무정형 단백질의 생물학적 활성 기전 및 질병 유발 기전 규명
  • 난치성 질환의 진단 및 치료를 위한 신규 유기 고분자/나노 화합물의 설계, 합성 및 응용
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Showing results 61 to 80 of 104

No. Year Title Type
61 2008

2008Article

The AP-2α transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN geneGlycobiology, vol. 18, no. 5, pp. 395-407H J Choi; T W Chung; S J Kim; S Y Cho; Y S Lee; Y C Lee; Jeong Heon Ko; C H Kim
Article
62 2008

2008Article

Membrane type sialidase inhibits the megakaryocytic differentiation of human leukemia K562 cellsBiochimica et Biophysica Acta-General Subjects, vol. 1780, no. 5, pp. 757-763U H Jin; K T Ha; K W Kim; Y C Chang; Y C Lee; Jeong Heon Ko; C H Kim
Article
63 2008

2008Article

Biochemical charactrization of a glycosyltransferase homolog from an oral pathogen Fusobacterium nucleatum as a human glycan-modifying enzymeJournal of Microbiology and Biotechnology, vol. 18, no. 5, pp. 859-865Seong Hun KimDoo-Byoung OhOh Suk Kwon; J K Jeong; Yun Mi Lee; K Ko; Jeong Heon Ko; H A Kang
Article
64 2008

2008Article

Development of a decoy immunization strategy to identify cell-surface molecules expressed on undifferentiated human embryonic stem cellsCell and Tissue Research, vol. 333, no. 2, pp. 197-206H S Choi; H Kim; A Won; J J Kim; C Y Son; K S Kim; Jeong Heon Ko; M Y Lee; C H Kim; C J Ryu
Article
65 2008

2008Article

Disialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cellsProteomics, vol. 8, no. 16, pp. 3317-3328S K Kang; Yong Sam Kim; Y J Kong; K H Song; Y C Chang; Y G Park; Jeong Heon Ko; Y C Lee; C H Kim
Article
66 2008

2008Article

Functional proteomic study reveals that N-acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on TIMP-1Molecular & Cellular Proteomics, vol. 7, no. 1, pp. 1-14Yong Sam Kim; S Y Hwang; Hye Yeon Kang; H Sohn; S Oh; J Y Kim; J S Yoo; Y H Kim; C H Kim; Jae Heung Jeon, et al.
Article
67 2008

2008Article

Development of patatin knockdown potato tubers using RNA interference (RNAi) technology, for the production of human-therapeutic glycoproteinsBMC Biotechnology, vol. 8, pp. 36-36Yoon Sik Kim; Yong Hwa Lee; Hyun Soon Kim; Mi Sun Kim; K W Hahn; Jeong Heon Ko; Hyouk Joung; Jae Heung Jeon
Article
68 2008

2008Article

Lectin precipitation using phytohemagglutinin-L(4) coupled to avidin-agarose for serological biomarker discovery in colorectal cancerProteomics, vol. 8, no. 16, pp. 3229-3235Yong Sam Kim; O L Son; J Y Lee; S H Kim; S Oh; Y S Lee; C H Kim; J S Yoo; J H Lee; E Miyoshi, et al.
Article
69 2007

2007Article

Molecular cloning and analysis of the Thermus caldophilus ADP-glucose pyrophosphorylaseEnzyme and Microbial Technology, vol. 41, no. 4, pp. 423-431Yong Sam Kim; H Sohn; U H Jin; S J Suh; Sang Chul Lee; Jae Heung Jeon; Dae Sil Lee; C H Kim; Jeong Heon Ko
Article
70 2007

2007Article

Expression of the human CMP-NeuAc:GM3 α2,8-sialyltransferase (GD3 synthase) gene through the NF-κB activation in human melanoma SK-MEL-2 cellsBiochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol. 1769, no. 11, pp. 622-630N Y Kang; C H Kim; K S Kim; Jeong Heon Ko; J H Lee; Y K Jeong; Y C Lee
Article
71 2007

2007Article

Overexpression of membrane sialic acid-specific sialidase Neu3 inhibits matrix metalloproteinase-9 expression in vascular smooth muscle cellsBiochemical and Biophysical Research Communications, vol. 356, no. 3, pp. 542-547S K Moon; S H Cho; K W Kim; Jae Heung Jeon; Jeong Heon KoBo Yeon Kim; C H Kim
Article
72 2006

2006Article

Identification of target proteins of N-acetylglucosaminyl transferase V in human colon cancer and implications of protein tyrosine phosphatase kappa in enhanced cancer cell migrationProteomics, vol. 6, no. 4, pp. 1187-1191Yong Sam Kim; Hye Yeon Kang; J Y Kim; S Oh; C H Kim; Chun Jeih Ryu; E Miyoshi; N Taniguchi; Jeong Heon Ko
Article
73 2006

2006Article

Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-κB in regulated expressionGlycobiology, vol. 16, no. 5, pp. 375-389Y Kang; S K Kang; Y C Lee; H J Choi; Y S Lee; S Y Cho; Yong Sam KimJeong Heon Ko; C H Kim
Article
74 2006

2006Article

Ganglioside GM3 is involved in neuronal cell deathFASEB Journal, vol. 20, no. 8, pp. 1248-1250Hosung Sohn; Yong Sam Kim; H T Kim; C H Kim; Eun Wie Cho; H Y Kang; Nam-Soon Kim; C H Kim; Seong Eon Ryu; J H Lee, et al.
Article
75 2006

2006Article

Alteration of the substrate specificity of Thermus caldophilus ADP-glucose pyrophosphorylase by random mutagenesis through error-prone polymerase chain reactionGlycoconjugate Journal, vol. 23, no. 9, pp. 619-625Hosung Sohn; Yong Sam Kim; U H Jin; S J Suh; Sang Chul Lee; Dae Sil Lee; Jeong Heon Ko; C H Kim
Article
76 2006

2006Article

Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21WAF1 and p27kip1 by inhibition of PI-3K/AKT pathwayGlycobiology, vol. 16, no. 7, pp. 573-583H J Choi; T W Chung; S K Kang; Y C Lee; Jeong Heon Ko; J G Kim; C H Kim
Article
77 2005

2005Article

Glycobiology of selectin = 셀렉틴의 당생물학: 암 및 염증의 발생과 전이에 관련하여Journal of Breast Cancer, vol. 8, no. 1, pp. 4-16Yong Sam KimJeong Heon Ko
Article
78 2005

2005Article

Heat shock 70-kDa protein 8 isoform 1 is expressed on the surface of human embryonic stem cells and downregulated upon differentiationStem Cells, vol. 23, no. 10, pp. 1502-1513Yeon Sung Son; Jae Hyun Park; Young Kook Kang; Jin Sung Park; Hong Seo Choi; Ji Young Lim; J E Le; J B Lee; M S Ko; Yong Sam Kim, et al.
Article
79 2005

2005Article

Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27Experimental and Molecular Medicine, vol. 37, no. 6, pp. 624-630Y J Seo; M H Jeon; J H Lee; Y J Lee; H J Youn; Jeong Heon Ko; J H Lee
Article
80 2004

2004Article

A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cellsLife Sciences, vol. 75, no. 19, pp. 2363-2375B S Koo; W C Lee; K H Chung; Jeong Heon Ko; C H Kim
Article
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