Troponin Aptamer on an Atomically Flat Au Nanoplate Platform for Detection of Cardiac Troponin I

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dc.contributor.authorH Lee-
dc.contributor.authorH Youn-
dc.contributor.authorAhreum Hwang-
dc.contributor.authorH Lee-
dc.contributor.authorJ Y Park-
dc.contributor.authorW Kim-
dc.contributor.authorY Yoo-
dc.contributor.authorC Ban-
dc.contributor.authorTaejoon Kang-
dc.contributor.authorB Kim-
dc.date.accessioned2020-08-25T08:43:23Z-
dc.date.available2020-08-25T08:43:23Z-
dc.date.issued2020-
dc.identifier.issn20794991-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19749-
dc.description.abstractWell-ordered bioreceptors on atomically flat Au surfaces can be a high-performance biosensor. Cardiac troponin I proteins (cTnIs) have been regarded as a specific biomarker for acute myocardial infarction (AMI). Here, we report the accurate detection of cTnIs using an aptamer-immobilized Au nanoplate platform. The single-crystalline and atomically flat Au nanoplate was characterized by atomic force microscopy. For the precise detection of cTnI, we immobilized an aptamer that can strongly bind to cTnI onto an atomically flat Au nanoplate. Using the aptamer-immobilized Au nanoplate, cTnIs were successfully detected at a concentration of 100 aM (2.4 fg/mL) in buffer solution. Furthermore, cTnIs in serum could be identified at a concentration of 100 fM (2.4 pg/mL). The total assay time was ~7 h. Importantly, the aptamer-immobilized Au nanoplate enabled us to diagnose AMI patients accurately, suggesting the potential of the present method in the diagnosis of AMI.-
dc.publisherMDPI-
dc.titleTroponin Aptamer on an Atomically Flat Au Nanoplate Platform for Detection of Cardiac Troponin I-
dc.title.alternativeTroponin Aptamer on an Atomically Flat Au Nanoplate Platform for Detection of Cardiac Troponin I-
dc.typeArticle-
dc.citation.titleNanomaterials-
dc.citation.number7-
dc.citation.endPage1402-
dc.citation.startPage1402-
dc.citation.volume10-
dc.contributor.affiliatedAuthorAhreum Hwang-
dc.contributor.affiliatedAuthorTaejoon Kang-
dc.contributor.alternativeName이효반-
dc.contributor.alternativeName윤형준-
dc.contributor.alternativeName황아름-
dc.contributor.alternativeName이현수-
dc.contributor.alternativeName박정영-
dc.contributor.alternativeName김원-
dc.contributor.alternativeName유영동-
dc.contributor.alternativeName반창일-
dc.contributor.alternativeName강태준-
dc.contributor.alternativeName김봉수-
dc.identifier.bibliographicCitationNanomaterials, vol. 10, no. 7, pp. 1402-1402-
dc.identifier.doi10.3390/nano10071402-
dc.subject.keywordcTnI-
dc.subject.keywordAptamer-
dc.subject.keywordNanoplate-
dc.subject.keywordSurface-enhanced Raman scattering-
dc.subject.localAptamer-
dc.subject.localSurface-enhanced Raman scattering-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
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