Xyloneside A: a new glycosylated incisterol derivative from Xylaria sp. FB = Xyloneside A: Xylaria sp.의 새로운 glycosylated Incisterol 유도체 FB

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Title
Xyloneside A: a new glycosylated incisterol derivative from Xylaria sp. FB = Xyloneside A: Xylaria sp.의 새로운 glycosylated Incisterol 유도체 FB
Author(s)
S R Lee; N B Kreuzenbeck; Mina Jang; Taehoon Oh; Sung-Kyun Ko; Jong Seog Ahn; C Beemelmanns; K H Kim
Bibliographic Citation
Chembiochem, vol. 21, no. 16, pp. 2253-2258
Publication Year
2020
Abstract
Xylaria species are prolific natural product producers. Here, we report the characterization of a new glycosylated incisterol derivative, called xyloneside A (1) and two known lignans (2 and 3) from the ascomycetous Xylaria sp. FB. The structure of xyloneside A (1) was determined by 1D and 2D NMR spectroscopy, high-resolution electrospray ionization mass spectrometry and electronic circular dichroism measurements. Xyloneside A is composed of a 1,2,3,4,5,10,19-heptanorergosterane skeleton and a β-D-mannopyranose moiety. This is the first report of an incisterol derivative from an Ascomycete. The biological effects of the isolated metabolites on cytotoxicity, autophagy, cell-migration, and angiogenesis were evaluated.
ISSN
1439-4227
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/cbic.202000065
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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