Inhibition of skin inflammation by scytonemin, an ultraviolet sunscreen pigment

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dc.contributor.authorMoo Rim Kang-
dc.contributor.authorSun Ah Jo-
dc.contributor.authorHyun Ju Lee-
dc.contributor.authorYeo Dae Yoon-
dc.contributor.authorJu Hee Kwon-
dc.contributor.authorJeong Wook Yang-
dc.contributor.authorByung Jo Choi-
dc.contributor.authorKi Hwan Park-
dc.contributor.authorMyung Youl Lee-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorKyeong-Ryoon Lee-
dc.contributor.authorJong Soon Kang-
dc.date.accessioned2020-08-25T10:03:09Z-
dc.date.available2020-08-25T10:03:09Z-
dc.date.issued2020-
dc.identifier.issn16603397-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/20134-
dc.description.abstractScytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytonemin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear swelling in BALB/c mice. The expression of tumor necrosis factor-a (TNF-a) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice. In addition, scytonemin inhibited lipopolysaccharide (LPS)-induced production of TNF-a and nitric oxide (NO) in RAW 264.7 cells, a murine macrophage-like cell line, and the mRNA expressions of TNF-a and iNOS were also suppressed by scytonemin in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced NF-kB activity was significantly suppressed by scytonemin treatment in RAW 264.7 cells. Our results also showed that the degradation of IkBa and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. Collectively, these results suggest that scytonemin inhibits skin inflammation by blocking the expression of inflammatory mediators, and the anti-inflammatory effect of scytonemin is mediated, at least in part, by down-regulation of NF-kB activity. Our results also suggest that scytonemin might be used as a multi-function skin care ingredient for UV protection and anti-inflammation.-
dc.publisherMDPI-
dc.titleInhibition of skin inflammation by scytonemin, an ultraviolet sunscreen pigment-
dc.title.alternativeInhibition of skin inflammation by scytonemin, an ultraviolet sunscreen pigment-
dc.typeArticle-
dc.citation.titleMarine Drugs-
dc.citation.number6-
dc.citation.endPage300-
dc.citation.startPage300-
dc.citation.volume18-
dc.contributor.affiliatedAuthorMoo Rim Kang-
dc.contributor.affiliatedAuthorSun Ah Jo-
dc.contributor.affiliatedAuthorHyun Ju Lee-
dc.contributor.affiliatedAuthorYeo Dae Yoon-
dc.contributor.affiliatedAuthorJu Hee Kwon-
dc.contributor.affiliatedAuthorJeong Wook Yang-
dc.contributor.affiliatedAuthorByung Jo Choi-
dc.contributor.affiliatedAuthorKi Hwan Park-
dc.contributor.affiliatedAuthorMyung Youl Lee-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorKyeong-Ryoon Lee-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName강무림-
dc.contributor.alternativeName조선아-
dc.contributor.alternativeName이현주-
dc.contributor.alternativeName윤여대-
dc.contributor.alternativeName권주희-
dc.contributor.alternativeName양정욱-
dc.contributor.alternativeName최병조-
dc.contributor.alternativeName박기환-
dc.contributor.alternativeName이명열-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName이경륜-
dc.contributor.alternativeName강종순-
dc.identifier.bibliographicCitationMarine Drugs, vol. 18, no. 6, pp. 300-300-
dc.identifier.doi10.3390/md18060300-
dc.subject.keywordscytonemin-
dc.subject.keywordskin inflammation-
dc.subject.keywordtumor necrosis factor--
dc.subject.keywordnitric oxide-
dc.subject.keywordNF-kB-
dc.subject.localscytonemin-
dc.subject.localskin inflammation-
dc.subject.localSkin inflammation-
dc.subject.localtumor necrosis factor--
dc.subject.localTumor necrosis factor-
dc.subject.localnitric oxide-
dc.subject.localNitric oxide (NO)-
dc.subject.localNF-kB-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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