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- 항-사이토케라틴 8/18 복합체 자가면역항체를 포함하는 암 진단 마커 및 이의 항원을 포함하는 암 진단용 조성물
- Alternative Title
- A MARKER COMPRISING ANTI-CK8/18 COMPLEX AUTOANTIBODIES AND A COMPOSITION COMPRISING ANTIGEN THEREOF FOR DIAGNOSING CANCER
- 유향숙; 고정헌; 황해민; 허창규; 우미경; 조은위
- Application No.
- 14/000,221 (2013.08.19)
- Registration No.
- 9,234,893 (2016.01.12)
- The present invention relates to a cytokeratin 8/18 complex-specific autoantibody or a fragment comprising an antigen-binding site (paratope) thereof, the use thereof in the diagnosis of breast cancer, a polypeptide having an amino acid sequence of an epitope specifically binding to the autoantibody, a composition for diagnosing breast cancer comprising an agent capable of measuring an expression level of the autoantibody or the fragment comprising an antigen-binding site thereof, a hybridoma cell line producing the autoantibody, and a kit for diagnosing breast cancer comprising the composition of the present invention. Further, the present invention relates to a method for diagnosing breast cancer, comprising the step of detecting the cytokeratin 8/18 complex-specific autoantibody or the fragment comprising the antigen-binding site thereof using the composition of the present invention, and a method for screening a therapeutic agent for breast cancer using the autoantibody.
- Appears in Collections:
- Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 2. Patents
Division of Biomedical Research > Rare Disease Research Center > 2. Patents
- Files in This Item:
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