H I F-1 α 활성을 저해하는 신규 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학조성물
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- Title
- H I F-1 α 활성을 저해하는 신규 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학조성물
- Alternative Title
- Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component
- Assignee(s)
- 한국생명공학연구원,동국대학교 산학협력단
- Application No.
- 15/067,057 (2016.03.10)
- Registration No.
- 9,789,114 (2017.10.17)
- Country
- 미국
- Abstract
- The present invention relates to novel compounds as HIF-1α inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1α, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1α-mediated VEGFA expression.
- Type
- Patent
- Appears in Collections:
- Division of A.I. & Biomedical Research > Genomic Medicine Research Center > 2. Patents
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