N-메틸렌나프토[2,1-b]퓨란-2-카보하이드라지드 유도체를 유효성분으로 포함하는 암 예방 또는 치료용 조성물

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Title
N-메틸렌나프토[2,1-b]퓨란-2-카보하이드라지드 유도체를 유효성분으로 포함하는 암 예방 또는 치료용 조성물
Alternative Title
Anti cancer and prevention Activity of (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate, a Novel Small Molecule Tubulin Inhibitor
Inventor(s)
안종석김보연장재혁성낙균; 크리사다; 류인자; 김선옥; 띠메오고단; 황준성
Assignee(s)
한국생명공학연구원
Application No.
14/641,065 (2015.03.06)
Registration No.
9,433,607 (2016.09.06)
Country
미국
Abstract
The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.
Type
Patent
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 2. Patents
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