TM4SF5에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도

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Title
TM4SF5에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도
Alternative Title
A novel TM4SF5 specific monoclonal antibody and use thereof
Inventor(s)
최인표; 김세미; 송진명; 민혜진; 안혜미; 김상직
Assignee(s)
한국생명공학연구원,서울대학교 산학협력단
Application No.
14/613,014 (2015.02.03)
Registration No.
9,815,900 (2017.11.14)
Country
미국
Abstract
The present invention relates to a novel monoclonal antibody which is specifically bound to a transmembrane 4 L six family member 5 (TM4SF5) protein. More particularly, the present invention relates to a monoclonal antibody which is specifically bound to a human TM4SF5 protein, to polynucleotides coding for the monoclonal antibody, to an expression vector comprising the nucleotides, to a transformant with the vector introduced thereto, to a method for preparing the monoclonal antibody, to a composition comprising the monoclonal antibody, to a method for treating liver fibrosis using the monoclonal antibody, to a method for treating cancer using the monoclonal antibody, to a method for inhibiting metastasis of cancer, to a method for diagnosing cancer using the monoclonal antibody and to a cancer diagnosis kit comprising the monoclonal antibody.
Type
Patent
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 2. Patents
Division of Biomaterials Research > Synthetic Biology and Bioengineering Research Center > 2. Patents
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