신규 튜불린 중합 저해제 및 그 합성방법

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Title
신규 튜불린 중합 저해제 및 그 합성방법
Alternative Title
A NOVEL TUBULIN POLYMERIZATION INHIBITO+.R, AND THE SYNTHESIZING METHOD THEREOF
Inventor(s)
안종석김보연장재혁; 크리사다; 류인자; 김선옥; 띠메오고단; 성낙균
Assignee(s)
한국생명공학연구원
Application No.
14/787,243 (2015.10.26)
Registration No.
9,643,959 (2017.05.09)
Country
미국
Abstract
The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.
Type
Patent
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 2. Patents
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