이형접합체 결손 분열효모 균주를 이용하는 약물에 대한 표적유전자스크리닝방법

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Title
이형접합체 결손 분열효모 균주를 이용하는 약물에 대한 표적유전자스크리닝방법
Alternative Title
-
Inventor(s)
허광래; 김동욱
Assignee(s)
한국생명공학연구원
Application No.
14/728,789 (2015.06.02)
Registration No.
10,174,312 (2019.01.08)
Country
미국
Abstract
The present invention relates to a screening method for a drug target gene by using chemical-genetic profile compendium of the heterozygous deletion fission yeast strain and the comparative genetic analysis using the same. More precisely, the present inventors constructed the chemical-genetic profile compendium for drug candidates from the heterozygous deletion fission yeast strain of Schizosaccharomyces pombe (S. pombe), and then compared with the compendium with the chemical-genetic profile compendium of the budding yeast Saccharomyces cerevisiae (S. cerevisiae) in order to select efficiently drug target genes showing drug sensitivity. The screening method of the present invention can be efficiently used for the identification of a drug target gene in various eukaryotes because it facilitates the selection of a drug target gene showing sensitivity to the drug from the chemical-genetic profile compendium of the heterozygous deletion fission yeast strain.
Type
Patent
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 2. Patents
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