2,3-부탄디올 합성 유전자가 결실된 미생물 변이체를 이용한 1,3-프로판디올의 제조방법

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Title
2,3-부탄디올 합성 유전자가 결실된 미생물 변이체를 이용한 1,3-프로판디올의 제조방법
Alternative Title
Methods for Peparing 1,3-Propanediol Using Variant of Microorganism Deleted 2,3-Butanediol Synthesis Gene
Inventor(s)
김철호오백록; 정유리; 서정우; 박장민; 허선연
Assignee(s)
한국생명공학연구원
Application No.
15/120,516 (2016.08.20)
Registration No.
9,896,701 (2018.02.20)
Country
미국
Abstract
The present invention relates to a method for producing 1,3-propanediol using a mutant microorganism lacking a 2,3-butanediol synthetic gene, and more particularly to a mutant microorganism wherein a gene encoding lactate dehydrogenase and a gene encoding an enzyme which is involved in 2,3-butanediol synthesis are deleted in a microorganism having the ability to produce 1,3-propanediol from glycerol and wherein a gene encoding pyruvate decarboxylase and a gene encoding aldehyde dehydrogenase are introduced or amplified, and to a method of promoting the production of 1,3-propanediol while inhibiting the production of 2,3-butanediol by using the mutant microorganism. The use of the glycerol-fermenting mutant microorganism according to the present invention can significantly increase the production of 1,3-propanediol while minimizing the production of 2,3-butanediol.
Type
Patent
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 2. Patents
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