신이 추출물, 분획물 또는 이의 활성분획물을 유효성분으로 함유하는 만성폐쇄성 폐질환 예방 및 치료용 약학적 조성물

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Title
신이 추출물, 분획물 또는 이의 활성분획물을 유효성분으로 함유하는 만성폐쇄성 폐질환 예방 및 치료용 약학적 조성물
Alternative Title
A composition comprising extracts, fractions or isolated active fractions of Magnoliae flos for prevention and treatment of chronic obstructive pulmonary disease
Inventor(s)
오세량안경섭; 이형규; 김두영권옥경이수의류형원김정희이현준
Assignee(s)
한국생명공학연구원
Application No.
15/573,207 (2017.11.10)
Registration No.
10,376,553 (2019.08.13)
Country
미국
Abstract
A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-α and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.
Type
Patent
Appears in Collections:
Ochang Branch Institute > 2. Patents
Ochang Branch Institute > Natural Product Research Center > 2. Patents
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