DC Field | Value | Language |
---|---|---|
dc.contributor.author | D B Jeon | - |
dc.contributor.author | H G Shin | - |
dc.contributor.author | B W Lee | - |
dc.contributor.author | S H Jeong | - |
dc.contributor.author | J H Kim | - |
dc.contributor.author | J H Ha | - |
dc.contributor.author | J Y Park | - |
dc.contributor.author | H J Kwon | - |
dc.contributor.author | W J Kim | - |
dc.contributor.author | Young Bae Ryu | - |
dc.contributor.author | In Chul Lee | - |
dc.date.accessioned | 2020-09-11T06:06:42Z | - |
dc.date.available | 2020-09-11T06:06:42Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0960-3271 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/21530 | - |
dc.description.abstract | Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute gastric injury. EF-2001 (20, 40, and 80 mg/kg/day) was administered by oral gavage for 5 days before EtOH treatment (10 mL/kg body weight). EF-2001 effectively attenuated EtOH-induced gastric mucosal injury with reduced gastric mucosal ulcer and histological damage score. Pretreatment of EF-2001 markedly suppressed the phosphorylation of mitogen-activated protein kinases (MAPKs; ERK1/2, JNK, and p38MAPK). In addition, EF-2001 significantly inhibited phosphorylation of nuclear factor kappa B (NF-κB) and subsequently suppressed the upregulation of inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 in gastric tissues. Taken together, these results suggest that EF-2001 exerts a gastroprotective effect against acute gastric injury, and the underlying mechanism might be associated with the suppression of MAPKs and NF-κB signaling and consequent reduction of pro-inflammatory mediators or cytokines. | - |
dc.publisher | Sage | - |
dc.title | Effect of heat-killed Enterococcus faecalis EF-2001 on ethanol-induced acute gastric injury in mice: protective effect of EF-2001 on acute gastric ulcer | - |
dc.title.alternative | Effect of heat-killed Enterococcus faecalis EF-2001 on ethanol-induced acute gastric injury in mice: protective effect of EF-2001 on acute gastric ulcer | - |
dc.type | Article | - |
dc.citation.title | Human & Experimental Toxicology | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 733 | - |
dc.citation.startPage | 721 | - |
dc.citation.volume | 39 | - |
dc.contributor.affiliatedAuthor | Young Bae Ryu | - |
dc.contributor.affiliatedAuthor | In Chul Lee | - |
dc.contributor.alternativeName | 전 | - |
dc.contributor.alternativeName | 신 | - |
dc.contributor.alternativeName | 이 | - |
dc.contributor.alternativeName | 정 | - |
dc.contributor.alternativeName | 김 | - |
dc.contributor.alternativeName | 하 | - |
dc.contributor.alternativeName | 박 | - |
dc.contributor.alternativeName | 권 | - |
dc.contributor.alternativeName | 김 | - |
dc.contributor.alternativeName | 류영배 | - |
dc.contributor.alternativeName | 이인철 | - |
dc.identifier.bibliographicCitation | Human & Experimental Toxicology, vol. 39, no. 5, pp. 721-733 | - |
dc.identifier.doi | 10.1177/0960327119899987 | - |
dc.subject.keyword | acute gastric ulcer | - |
dc.subject.keyword | anti-inflammatory activity | - |
dc.subject.keyword | Enterococcus faecalis EF-2001 | - |
dc.subject.keyword | Ethanol | - |
dc.subject.keyword | MAPK/NF-κB pathway | - |
dc.subject.local | acute gastric ulcer | - |
dc.subject.local | Anti-inflammatory activity | - |
dc.subject.local | Anti-infl ammatory activity | - |
dc.subject.local | anti-inflammatory activity | - |
dc.subject.local | Anti-inflammatory activities | - |
dc.subject.local | Enterococcus faecalis EF-2001 | - |
dc.subject.local | Ethanol | - |
dc.subject.local | ETHANOL | - |
dc.subject.local | ethanol | - |
dc.subject.local | MAPK/NF-κB pathway | - |
dc.description.journalClass | Y | - |
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