Effect of heat-killed Enterococcus faecalis EF-2001 on ethanol-induced acute gastric injury in mice: protective effect of EF-2001 on acute gastric ulcer

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dc.contributor.authorD B Jeon-
dc.contributor.authorH G Shin-
dc.contributor.authorB W Lee-
dc.contributor.authorS H Jeong-
dc.contributor.authorJ H Kim-
dc.contributor.authorJ H Ha-
dc.contributor.authorJ Y Park-
dc.contributor.authorH J Kwon-
dc.contributor.authorW J Kim-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorIn Chul Lee-
dc.date.accessioned2020-09-11T06:06:42Z-
dc.date.available2020-09-11T06:06:42Z-
dc.date.issued2020-
dc.identifier.issn0960-3271-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/21530-
dc.description.abstractEnterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute gastric injury. EF-2001 (20, 40, and 80 mg/kg/day) was administered by oral gavage for 5 days before EtOH treatment (10 mL/kg body weight). EF-2001 effectively attenuated EtOH-induced gastric mucosal injury with reduced gastric mucosal ulcer and histological damage score. Pretreatment of EF-2001 markedly suppressed the phosphorylation of mitogen-activated protein kinases (MAPKs; ERK1/2, JNK, and p38MAPK). In addition, EF-2001 significantly inhibited phosphorylation of nuclear factor kappa B (NF-κB) and subsequently suppressed the upregulation of inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 in gastric tissues. Taken together, these results suggest that EF-2001 exerts a gastroprotective effect against acute gastric injury, and the underlying mechanism might be associated with the suppression of MAPKs and NF-κB signaling and consequent reduction of pro-inflammatory mediators or cytokines.-
dc.publisherSage-
dc.titleEffect of heat-killed Enterococcus faecalis EF-2001 on ethanol-induced acute gastric injury in mice: protective effect of EF-2001 on acute gastric ulcer-
dc.title.alternativeEffect of heat-killed Enterococcus faecalis EF-2001 on ethanol-induced acute gastric injury in mice: protective effect of EF-2001 on acute gastric ulcer-
dc.typeArticle-
dc.citation.titleHuman & Experimental Toxicology-
dc.citation.number5-
dc.citation.endPage733-
dc.citation.startPage721-
dc.citation.volume39-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName이인철-
dc.identifier.bibliographicCitationHuman & Experimental Toxicology, vol. 39, no. 5, pp. 721-733-
dc.identifier.doi10.1177/0960327119899987-
dc.subject.keywordacute gastric ulcer-
dc.subject.keywordanti-inflammatory activity-
dc.subject.keywordEnterococcus faecalis EF-2001-
dc.subject.keywordEthanol-
dc.subject.keywordMAPK/NF-κB pathway-
dc.subject.localacute gastric ulcer-
dc.subject.localAnti-inflammatory activity-
dc.subject.localAnti-infl ammatory activity-
dc.subject.localanti-inflammatory activity-
dc.subject.localAnti-inflammatory activities-
dc.subject.localEnterococcus faecalis EF-2001-
dc.subject.localEthanol-
dc.subject.localETHANOL-
dc.subject.localethanol-
dc.subject.localMAPK/NF-κB pathway-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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