RNA-seq based transcriptome analysis of EHMT2 functions in breast cancer

Cited 3 time in scopus
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Title
RNA-seq based transcriptome analysis of EHMT2 functions in breast cancer
Author(s)
Kwangho Kim; Tae Young Ryu; Jea Woon Ryu; Tae Su HanCho Rok JungMi Young SonDae Soo KimHyun Soo Cho
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 524, pp. 672-676
Publication Year
2020
Abstract
For breast cancer treatment, hormone therapy is effective for hormone receptor-positive breast cancer but not for TNBC (triple-negative breast cancer). Thus, many researchers have attempted to identify more effective therapeutic candidates for all subtypes of breast cancer. In this study, we established an RNA-seq analytical pipeline to analyze the subtype-specific functions of EHMT2 in the MB231 and MCF7 cell lines. After EHMT2 knockdown, we identified subtype-specific DEGs (differentially expressed genes) and overlapping DEGs. Through GO (Gene Ontology) analysis, GSEA (gene set enrichment analysis), and KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis using the DEGs, we identified the subtype-specific functions of EHMT2 in the MB231 and MCF7 cell lines. Therefore, herein, we suggest that EHMT2 is an attractive therapeutic target for the treatment of all types of breast cancer.
Keyword
Breast cancerEHMT2RNA-seq
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2020.01.128
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
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