Anti-allergy effect of mojabanchromanol isolated from Sargassum horneri in bone marrow-derived cultured mast cells

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dc.contributor.authorH S Kim-
dc.contributor.authorE J Han-
dc.contributor.authorI P S Fernando-
dc.contributor.authorK K A Sanjeewa-
dc.contributor.authorT u Jayawardena-
dc.contributor.authorH J Kim-
dc.contributor.authorY Jee-
dc.contributor.authorS H Kang-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorJun-Pil Jang-
dc.contributor.authorK H I N M Herath-
dc.contributor.authorY J Jeon-
dc.contributor.authorG Ahn-
dc.date.accessioned2020-09-24T03:10:51Z-
dc.date.available2020-09-24T03:10:51Z-
dc.date.issued2020-
dc.identifier.issn22119264-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22645-
dc.description.abstractThis study was conducted to isolate and identify an active compound possessing anti-allergic property from the Jeju Island inhabiting Sargassum horneri (S. horneri). The ethanol extract of S. horneri (SHE) exhibited an anti-allergic effect via the reduction of β-hexosaminidase release in immunoglobulin E (IgE)/bovine serum albumin (BSA)-stimulated bone marrow-derived cultured mast cells (BMCMCs). SHE was subjected to liquid phase fractionation obtaining the hexane fraction, and this was further purified via ODS column chromatography and prep-C18 HPLC. The isolated compound was identified as mojabanchromanol (MC) by 1H, 13C NMR, and LCMS analysis. Isolated MC showed a higher inhibitory effect on the β-hexosaminidase release than those of SHE without cytotoxicity. Moreover, MC inhibited the mRNA expression levels of allergic cytokines in BMCMCs. This is the first report to inform on the anti-allergic property of MC isolated from S. horneri. In conclusion, SHE, as well as MC, is applicable in the development of functional health food, cosmetics, and pharmaceutical products exhibiting anti-allergic effects.-
dc.publisherElsevier-
dc.titleAnti-allergy effect of mojabanchromanol isolated from Sargassum horneri in bone marrow-derived cultured mast cells-
dc.title.alternativeAnti-allergy effect of mojabanchromanol isolated from Sargassum horneri in bone marrow-derived cultured mast cells-
dc.typeArticle-
dc.citation.titleAlgal Research-Biomass Biofuels and Bioproducts-
dc.citation.number0-
dc.citation.endPage101898-
dc.citation.startPage101898-
dc.citation.volume48-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJun-Pil Jang-
dc.contributor.alternativeName김현수-
dc.contributor.alternativeName한의정-
dc.contributor.alternativeNameFernando-
dc.contributor.alternativeNameSanjeewa-
dc.contributor.alternativeNameJayawardena-
dc.contributor.alternativeName김학주-
dc.contributor.alternativeName지영흔-
dc.contributor.alternativeName강세희-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName장준필-
dc.contributor.alternativeNameHerath-
dc.contributor.alternativeName전유진-
dc.contributor.alternativeName안긴래-
dc.identifier.bibliographicCitationAlgal Research-Biomass Biofuels and Bioproducts, vol. 48, pp. 101898-101898-
dc.identifier.doi10.1016/j.algal.2020.101898-
dc.subject.keywordAnti-allergy-
dc.subject.keywordBrown seaweed-
dc.subject.keywordMast cells-
dc.subject.keywordMojabanchromanol-
dc.subject.keywordSargassum horneri-
dc.subject.localAnti-allergy-
dc.subject.localBrown seaweed-
dc.subject.localMast cells-
dc.subject.localMast cell-
dc.subject.localMojabanchromanol-
dc.subject.localSargassum horneri-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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