Anti-allergy effect of mojabanchromanol isolated from Sargassum horneri in bone marrow-derived cultured mast cells

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Title
Anti-allergy effect of mojabanchromanol isolated from Sargassum horneri in bone marrow-derived cultured mast cells
Author(s)
H S Kim; E J Han; I P S Fernando; K K A Sanjeewa; T u Jayawardena; H J Kim; Y Jee; S H Kang; Jae-Hyuk JangJun-Pil Jang; K H I N M Herath; Y J Jeon; G Ahn
Bibliographic Citation
Algal Research-Biomass Biofuels and Bioproducts, vol. 48, pp. 101898-101898
Publication Year
2020
Abstract
This study was conducted to isolate and identify an active compound possessing anti-allergic property from the Jeju Island inhabiting Sargassum horneri (S. horneri). The ethanol extract of S. horneri (SHE) exhibited an anti-allergic effect via the reduction of β-hexosaminidase release in immunoglobulin E (IgE)/bovine serum albumin (BSA)-stimulated bone marrow-derived cultured mast cells (BMCMCs). SHE was subjected to liquid phase fractionation obtaining the hexane fraction, and this was further purified via ODS column chromatography and prep-C18 HPLC. The isolated compound was identified as mojabanchromanol (MC) by 1H, 13C NMR, and LCMS analysis. Isolated MC showed a higher inhibitory effect on the β-hexosaminidase release than those of SHE without cytotoxicity. Moreover, MC inhibited the mRNA expression levels of allergic cytokines in BMCMCs. This is the first report to inform on the anti-allergic property of MC isolated from S. horneri. In conclusion, SHE, as well as MC, is applicable in the development of functional health food, cosmetics, and pharmaceutical products exhibiting anti-allergic effects.
Keyword
Anti-allergyBrown seaweedMast cellsMojabanchromanolSargassum horneri
ISSN
2211-9264
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.algal.2020.101898
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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