Dysregulation of Rho GTPases in human cancers

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dc.contributor.authorHaiyoung Jung-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorJeewon Lim-
dc.contributor.authorHee Jun Cho-
dc.contributor.authorHee Gu Lee-
dc.date.accessioned2020-09-24T03:13:29Z-
dc.date.available2020-09-24T03:13:29Z-
dc.date.issued2020-
dc.identifier.issn2072-6694-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22652-
dc.description.abstractRho GTPases play central roles in numerous cellular processes, including cell motility, cell polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell adhesion. Dysregulation of Rho GTPase signaling is observed in a broad range of human cancers, and is associated with cancer development and malignant phenotypes, including metastasis and chemoresistance. Rho GTPase activity is precisely controlled by guanine nucleotide exchange factors, GTPase-activating proteins, and guanine nucleotide dissociation inhibitors. Recent evidence demonstrates that it is also regulated by post-translational modifications, such as phosphorylation, ubiquitination, and sumoylation. Here, we review the current knowledge on the role of Rho GTPases, and the precise mechanisms controlling their activity in the regulation of cancer progression. In addition, we discuss targeting strategies for the development of new drugs to improve cancer therapy.-
dc.publisherMDPI-
dc.titleDysregulation of Rho GTPases in human cancers-
dc.title.alternativeDysregulation of Rho GTPases in human cancers-
dc.typeArticle-
dc.citation.titleCancers-
dc.citation.number5-
dc.citation.endPage1179-
dc.citation.startPage1179-
dc.citation.volume12-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorJeewon Lim-
dc.contributor.affiliatedAuthorHee Jun Cho-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.alternativeName정해용-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName임지원-
dc.contributor.alternativeName조희준-
dc.contributor.alternativeName이희구-
dc.identifier.bibliographicCitationCancers, vol. 12, no. 5, pp. 1179-1179-
dc.identifier.doi10.3390/cancers12051179-
dc.subject.keywordCancer-
dc.subject.keywordChemoresistance-
dc.subject.keywordMetastasis-
dc.subject.keywordMigration-
dc.subject.keywordRho GTPases-
dc.subject.localCancers-
dc.subject.localcancer-
dc.subject.localCancer-
dc.subject.localchemoresistance-
dc.subject.localChemoresistance-
dc.subject.localChemo-resistance-
dc.subject.localmetastasis-
dc.subject.localMetastasis-
dc.subject.localMigration-
dc.subject.localmigration-
dc.subject.localRho GTPases-
dc.description.journalClassY-
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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