DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ba Wool Lee | - |
dc.contributor.author | Ji Hye Ha | - |
dc.contributor.author | Han Gyo Shin | - |
dc.contributor.author | S H Jeong | - |
dc.contributor.author | Ju Hong Kim | - |
dc.contributor.author | Jihye Lee | - |
dc.contributor.author | Ji Young Park | - |
dc.contributor.author | Hyung Jun Kwon | - |
dc.contributor.author | Kyungsook Jung | - |
dc.contributor.author | Woo Song Lee | - |
dc.contributor.author | Young Bae Ryu | - |
dc.contributor.author | J H Jeong | - |
dc.contributor.author | In Chul Lee | - |
dc.date.accessioned | 2020-09-24T03:36:59Z | - |
dc.date.available | 2020-09-24T03:36:59Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/22715 | - |
dc.description.abstract | Lindera obtusiloba is widespread in northeast Asia and used for treatment of improvement of blood circulation and anti-inflammation. In this study, we investigated anti-inflammatory and anti-oxidant effects of the methanolic extract of L. obtusiloba leaves (LOL) in an ovalbumin (OVA)-challenged allergic asthma model and tumor necrosis factor (TNF)-α-stimulated NCI-H292 cell. Female BALB/c mice were sensitized with OVA by intraperitoneal injection on days 0 and 14, and airway-challenged with OVA from days 21 to 23. Mice were administered 50 and 100 mg/kg of LOL by oral gavage 1 h before the challenge. LOL treatment effectively decreased airway hyper-responsiveness and inhibited inflammatory cell recruitment, Th2 cytokines, mucin 5AC (MUC5AC) in bronchoalveolar lavage fluid in OVA-challenged mice, which were accompanied by marked suppression of airway inflammation and mucus production in the lung tissue. LOL pretreatment inhibited the phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) with suppression of activator protein (AP)-1 and MUC5AC in the lung tissue. LOL also down-regulated expression of inflammatory cytokines, and inhibited the activation of NF-κB in TNF-α-stimulated NCI-H292 cells. LOL elevated the translocation of nuclear factor-erythroid 2-related factor (Nrf-2) into nucleus concurrent with increase of heme oxyngenase-1 (HO-1) and NAD(P)H quinine oxidoreductase 1 (NQO1). Moreover, LOL treatment exhibited a marked increase in the anti-oxidant enzymes activities, whereas effectively suppressed the production of reactive oxygen species and nitric oxide, as well as lipid peroxidation in lung tissue of OVA-challenged mice and TNF-α-stimulated NCI-H292 cells. These findings suggest that LOL might serve as a therapeutic agent for the treatment of allergic asthma. | - |
dc.publisher | MDPI | - |
dc.title | Lindera obtusiloba attenuates oxidative stress and airway inflammation in a murine model of ovalbumin-challenged asthma | - |
dc.title.alternative | Lindera obtusiloba attenuates oxidative stress and airway inflammation in a murine model of ovalbumin-challenged asthma | - |
dc.type | Article | - |
dc.citation.title | Antioxidants | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 563 | - |
dc.citation.startPage | 563 | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Ba Wool Lee | - |
dc.contributor.affiliatedAuthor | Ji Hye Ha | - |
dc.contributor.affiliatedAuthor | Han Gyo Shin | - |
dc.contributor.affiliatedAuthor | Ju Hong Kim | - |
dc.contributor.affiliatedAuthor | Jihye Lee | - |
dc.contributor.affiliatedAuthor | Ji Young Park | - |
dc.contributor.affiliatedAuthor | Hyung Jun Kwon | - |
dc.contributor.affiliatedAuthor | Kyungsook Jung | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.affiliatedAuthor | Young Bae Ryu | - |
dc.contributor.affiliatedAuthor | In Chul Lee | - |
dc.contributor.alternativeName | 이바울 | - |
dc.contributor.alternativeName | 하지혜 | - |
dc.contributor.alternativeName | 신한교 | - |
dc.contributor.alternativeName | 정성훈 | - |
dc.contributor.alternativeName | 김주홍 | - |
dc.contributor.alternativeName | 이지혜 | - |
dc.contributor.alternativeName | 박지영 | - |
dc.contributor.alternativeName | 권형준 | - |
dc.contributor.alternativeName | 정경숙 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.contributor.alternativeName | 류영배 | - |
dc.contributor.alternativeName | 정재호 | - |
dc.contributor.alternativeName | 이인철 | - |
dc.identifier.bibliographicCitation | Antioxidants, vol. 9, no. 7, pp. 563-563 | - |
dc.identifier.doi | 10.3390/antiox9070563 | - |
dc.subject.keyword | Lindera obtusiloba | - |
dc.subject.keyword | allergic asthma | - |
dc.subject.keyword | anti-oxidants activity | - |
dc.subject.keyword | nuclear factor-erythroid 2-related factor | - |
dc.subject.keyword | mitogen-activated protein kinases | - |
dc.subject.keyword | nuclear factor-kappaB | - |
dc.subject.local | Lindera obtusiloba | - |
dc.subject.local | Allergic asthma | - |
dc.subject.local | allergic asthma | - |
dc.subject.local | Anti-oxidant activity | - |
dc.subject.local | Antioxidant activity | - |
dc.subject.local | anti-oxidant activity | - |
dc.subject.local | anti-oxidants activity | - |
dc.subject.local | antioxidant activity | - |
dc.subject.local | Nuclear factor erythroid 2-related factor | - |
dc.subject.local | nuclear factor-erythroid 2-related factor | - |
dc.subject.local | mitogen activated protein kinase | - |
dc.subject.local | mitogen-activated protein kinase | - |
dc.subject.local | mitogen-activated protein kinases | - |
dc.subject.local | Mitogen activated protein kinase | - |
dc.subject.local | Mitogen-acti-vated protein kinase | - |
dc.subject.local | Mitogen-activated protein kinase | - |
dc.subject.local | Mitogen-activated protein kinase (MAPK) | - |
dc.subject.local | Mitogen-activated protein kinases | - |
dc.subject.local | Mitogen-activated protein kinases (MAPKs) | - |
dc.subject.local | Mitogen-activated protein (MAP) kinase | - |
dc.subject.local | Mitogenactivated protein kinase | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.description.journalClass | Y | - |
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