Lindera obtusiloba attenuates oxidative stress and airway inflammation in a murine model of ovalbumin-challenged asthma

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dc.contributor.authorBa Wool Lee-
dc.contributor.authorJi Hye Ha-
dc.contributor.authorHan Gyo Shin-
dc.contributor.authorS H Jeong-
dc.contributor.authorJu Hong Kim-
dc.contributor.authorJihye Lee-
dc.contributor.authorJi Young Park-
dc.contributor.authorHyung Jun Kwon-
dc.contributor.authorKyungsook Jung-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorJ H Jeong-
dc.contributor.authorIn Chul Lee-
dc.date.accessioned2020-09-24T03:36:59Z-
dc.date.available2020-09-24T03:36:59Z-
dc.date.issued2020-
dc.identifier.issn20763921-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22715-
dc.description.abstractLindera obtusiloba is widespread in northeast Asia and used for treatment of improvement of blood circulation and anti-inflammation. In this study, we investigated anti-inflammatory and anti-oxidant effects of the methanolic extract of L. obtusiloba leaves (LOL) in an ovalbumin (OVA)-challenged allergic asthma model and tumor necrosis factor (TNF)-α-stimulated NCI-H292 cell. Female BALB/c mice were sensitized with OVA by intraperitoneal injection on days 0 and 14, and airway-challenged with OVA from days 21 to 23. Mice were administered 50 and 100 mg/kg of LOL by oral gavage 1 h before the challenge. LOL treatment effectively decreased airway hyper-responsiveness and inhibited inflammatory cell recruitment, Th2 cytokines, mucin 5AC (MUC5AC) in bronchoalveolar lavage fluid in OVA-challenged mice, which were accompanied by marked suppression of airway inflammation and mucus production in the lung tissue. LOL pretreatment inhibited the phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) with suppression of activator protein (AP)-1 and MUC5AC in the lung tissue. LOL also down-regulated expression of inflammatory cytokines, and inhibited the activation of NF-κB in TNF-α-stimulated NCI-H292 cells. LOL elevated the translocation of nuclear factor-erythroid 2-related factor (Nrf-2) into nucleus concurrent with increase of heme oxyngenase-1 (HO-1) and NAD(P)H quinine oxidoreductase 1 (NQO1). Moreover, LOL treatment exhibited a marked increase in the anti-oxidant enzymes activities, whereas effectively suppressed the production of reactive oxygen species and nitric oxide, as well as lipid peroxidation in lung tissue of OVA-challenged mice and TNF-α-stimulated NCI-H292 cells. These findings suggest that LOL might serve as a therapeutic agent for the treatment of allergic asthma.-
dc.publisherMDPI-
dc.titleLindera obtusiloba attenuates oxidative stress and airway inflammation in a murine model of ovalbumin-challenged asthma-
dc.title.alternativeLindera obtusiloba attenuates oxidative stress and airway inflammation in a murine model of ovalbumin-challenged asthma-
dc.typeArticle-
dc.citation.titleAntioxidants-
dc.citation.number7-
dc.citation.endPage563-
dc.citation.startPage563-
dc.citation.volume9-
dc.contributor.affiliatedAuthorBa Wool Lee-
dc.contributor.affiliatedAuthorJi Hye Ha-
dc.contributor.affiliatedAuthorHan Gyo Shin-
dc.contributor.affiliatedAuthorJu Hong Kim-
dc.contributor.affiliatedAuthorJihye Lee-
dc.contributor.affiliatedAuthorJi Young Park-
dc.contributor.affiliatedAuthorHyung Jun Kwon-
dc.contributor.affiliatedAuthorKyungsook Jung-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.alternativeName이바울-
dc.contributor.alternativeName하지혜-
dc.contributor.alternativeName신한교-
dc.contributor.alternativeName정성훈-
dc.contributor.alternativeName김주홍-
dc.contributor.alternativeName이지혜-
dc.contributor.alternativeName박지영-
dc.contributor.alternativeName권형준-
dc.contributor.alternativeName정경숙-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName정재호-
dc.contributor.alternativeName이인철-
dc.identifier.bibliographicCitationAntioxidants, vol. 9, no. 7, pp. 563-563-
dc.identifier.doi10.3390/antiox9070563-
dc.subject.keywordLindera obtusiloba-
dc.subject.keywordallergic asthma-
dc.subject.keywordanti-oxidants activity-
dc.subject.keywordnuclear factor-erythroid 2-related factor-
dc.subject.keywordmitogen-activated protein kinases-
dc.subject.keywordnuclear factor-kappaB-
dc.subject.localLindera obtusiloba-
dc.subject.localallergic asthma-
dc.subject.localAllergic asthma-
dc.subject.localanti-oxidants activity-
dc.subject.localAntioxidant activity-
dc.subject.localnuclear factor-erythroid 2-related factor-
dc.subject.localmitogen-activated protein kinases-
dc.subject.localmitogen-activated protein kinase-
dc.subject.localnuclear factor-kappaB-
dc.subject.localNuclear factor κB (NF-κB)-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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