Bioinformatics analysis of evolution and human disease related transposable element-derived microRNAs

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Title
Bioinformatics analysis of evolution and human disease related transposable element-derived microRNAs
Author(s)
Hee Eun Lee; Jae Won Huh; H S Kim
Bibliographic Citation
Life-Basel, vol. 10, no. 6, pp. 95-95
Publication Year
2020
Abstract
Transposable element (TE) has the ability to insert into certain parts of the genome, and due to this event, it is possible for TEs to generate new factors and one of these factors are microRNAs (miRNA). miRNAs are non-coding RNAs made up of 19 to 24 nucleotides and numerous miRNAs are derived from TE. In this study, to support general knowledge on TE and miRNAs derived from TE, several bioinformatics tools and databases were used to analyze miRNAs derived from TE in two aspects: evolution and human disease. The distribution of TEs in diverse species presents that almost half of the genome is covered with TE in mammalians and less than a half in other vertebrates and invertebrates. Based on selected evolution-related miRNAs studies, a total of 51 miRNAs derived from TE were found and analyzed. For the human disease-related miRNAs, total of 34 miRNAs derived from TE were organized from the previous studies. In summary, abundant miRNAs derived from TE are found, however, the function of miRNAs derived from TE is not informed either. Therefore, this study provides theoretical understanding of miRNAs derived from TE by using various bioinformatics tools.
Keyword
evolutionhuman diseasemicroRNAtransposable elementstransposable element derived microRNA
ISSN
2075-1729
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/life10060095
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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