Regulation of hematopoietic stem cell fate and malignancy

Cited 3 time in scopus
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Title
Regulation of hematopoietic stem cell fate and malignancy
Author(s)
Hee Jun ChoJungwoon LeeSuk Ran YoonHee Gu LeeHaiyoung Jung
Bibliographic Citation
International Journal of Molecular Sciences, vol. 21, no. 13, pp. 4780-4780
Publication Year
2020
Abstract
The regulation of hematopoietic stem cell (HSC) fate decision, whether they keep quiescence, self-renew, or differentiate into blood lineage cells, is critical for maintaining the immune system throughout one's lifetime. As HSCs are exposed to age-related stress, they gradually lose their self-renewal and regenerative capacity. Recently, many reports have implicated signaling pathways in the regulation of HSC fate determination and malignancies under aging stress or pathophysiological conditions. In this review, we focus on the current understanding of signaling pathways that regulate HSC fate including quiescence, self-renewal, and differentiation during aging, and additionally introduce pharmacological approaches to rescue defects of HSC fate determination or hematopoietic malignancies by kinase signaling pathways.
Keyword
hematopoietic stem cellagingquiescenceself-renewaldifferentiationkinase inhibitor
ISSN
1422-0067
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms21134780
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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