Mojabanchromanol isolated from Sargassum horneri attenuates particulate matter induced inflammatory responses via suppressing TLR2/4/7-MAPK signaling in MLE-12 cells

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Title
Mojabanchromanol isolated from Sargassum horneri attenuates particulate matter induced inflammatory responses via suppressing TLR2/4/7-MAPK signaling in MLE-12 cells
Author(s)
K H I N M Herath; H J Kim; Jae-Hyuk Jang; H S Kim; H J Kim; Y J Jeon; Y Jee
Bibliographic Citation
Marine Drugs, vol. 18, no. 7, pp. 355-355
Publication Year
2020
Abstract
Chromanols from marine algae are studied for drug development due to its prominent bioactive properties, and mojabanchromanol (MC), a chromanol isolated from a brown algae Sargassum horneri, is found to possess anti-oxidant potential. In this study, we hypothesized MC may attenuate particulate matter (PM)-induced and reactive oxygen species (ROS)-mediated inflammatory responses in airways and tried to identify its potential and underlying mechanism against PM (majority <2.5 μm in diameter)-induced inflammatory responses in a lung type II alveolar epithelial cell line, MLE-12. MC attenuated PM-induced malondialdehyde (MDA), a lipid peroxidation end product, and 8-hydroxydeoxyguanosine (8-OHdG), the most representative DNA oxidative damage product, further validating MC's potential in attenuating PM-induced oxidative stress. MC also suppressed PM-triggered TLR2/4/7 activation in MLE-12 cells. Moreover, MC reduced ROS-mediated phosphorylation of mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun NH (2)-terminal kinase (JNK) that were also activated in PM exposed cells. MC further inhibited the secretion of pro-inflammatory cytokines (IL-6, IL-1β and IL-33) in MLE-12 cells exposed to PM. These results provide a clear evidence for MC's potential in attenuating PM-triggered inflammatory responses in MLE-12 cells via repressing TLR2/4/7 and MAPK signaling. Therefore, MC can be developed as a therapeutic agent against PM induced airway inflammatory responses.
Keyword
MojabanchromanolTLR2/4/7MAPKIL-1βIL-6Sargassum horneri
ISSN
1660-3397
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/md18070355
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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