CPPF, a novel microtubule targeting anticancer agent, inhibits the growth of a wide variety of cancers

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dc.contributor.authorHo Jin Han-
dc.contributor.authorChanmi Park-
dc.contributor.authorJoonsung Hwang-
dc.contributor.authorN R Thimmegowda-
dc.contributor.authorSun Ok Kim-
dc.contributor.authorJunyeol Han-
dc.contributor.authorMinsik Woo-
dc.contributor.authorB Shwetha-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorKyung Ho Lee-
dc.contributor.authorHyunjoo Cha-
dc.contributor.authorY T Kwon-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorNak Kyun Soung-
dc.date.accessioned2020-09-24T03:42:31Z-
dc.date.available2020-09-24T03:42:31Z-
dc.date.issued2020-
dc.identifier.issn14220067-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22732-
dc.description.abstractIn the past, several microtubule targeting agents (MTAs) have been developed into successful anticancer drugs. However, the usage of these drugs has been limited by the acquisition of drug resistance in many cancers. Therefore, there is a constant demand for the development of new therapeutic drugs. Here we report the discovery of 5-5 (3-cchlorophenyl)-N-(3-pyridinyl)-2-furamide (CPPF), a novel microtubule targeting anticancer agent. Using both 2D and 3D culture systems, we showed that CPPF was able to suppress the proliferation of diverse cancer cell lines. In addition, CPPF was able to inhibit the growth of multidrug-resistant cell lines that are resistant to other MTAs, such as paclitaxel and colchicine. Our results showed that CPPF inhibited growth by depolymerizing microtubules leading to mitotic arrest and apoptosis. We also confirmed CPPF anticancer effects in vivo using both a mouse xenograft and a two-step skin cancer mouse model. Using established zebrafish models, we showed that CPPF has low toxicity in vivo. Overall, our study proves that CPPF has the potential to become a successful anticancer chemotherapeutic drug.-
dc.publisherMDPI-
dc.titleCPPF, a novel microtubule targeting anticancer agent, inhibits the growth of a wide variety of cancers-
dc.title.alternativeCPPF, a novel microtubule targeting anticancer agent, inhibits the growth of a wide variety of cancers-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.number13-
dc.citation.endPage4800-
dc.citation.startPage4800-
dc.citation.volume21-
dc.contributor.affiliatedAuthorHo Jin Han-
dc.contributor.affiliatedAuthorChanmi Park-
dc.contributor.affiliatedAuthorJoonsung Hwang-
dc.contributor.affiliatedAuthorSun Ok Kim-
dc.contributor.affiliatedAuthorJunyeol Han-
dc.contributor.affiliatedAuthorMinsik Woo-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorKyung Ho Lee-
dc.contributor.affiliatedAuthorHyunjoo Cha-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorNak Kyun Soung-
dc.contributor.alternativeName한호진-
dc.contributor.alternativeName박찬미-
dc.contributor.alternativeName황준성-
dc.contributor.alternativeNameThimmegowda-
dc.contributor.alternativeName김선옥-
dc.contributor.alternativeName한준열-
dc.contributor.alternativeName우민식-
dc.contributor.alternativeNameShwetha-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName이경호-
dc.contributor.alternativeName차현주-
dc.contributor.alternativeName권용태-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName성낙균-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, vol. 21, no. 13, pp. 4800-4800-
dc.identifier.doi10.3390/ijms21134800-
dc.subject.keywordmicrotubule target agent-
dc.subject.keywordanticancer drug-
dc.subject.keywordskin cancer prevention/animal model-
dc.subject.keywordmultidrug resistance-
dc.subject.keywordCPPF-
dc.subject.localmicrotubule target agent-
dc.subject.localanticancer drug-
dc.subject.localAnticancer drug-
dc.subject.localskin cancer prevention/animal model-
dc.subject.localmultidrug resistance-
dc.subject.localmultidrug-resistance (MDR)-
dc.subject.localCPPF-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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