Prevalence and characterization of Clostridium perfringens isolated from feces of captive cynomolgus monkeys (Macaca fascicularis)

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Title
Prevalence and characterization of Clostridium perfringens isolated from feces of captive cynomolgus monkeys (Macaca fascicularis)
Author(s)
Bon Sang Koo; Eun Ha Hwang; Green Kim; Joon Young Park; Hanseul OhKyung Seob LimPhilyong KangHwal Yong LeeKang Jin Jeong; I Mo; F Villinger; Jung Joo Hong
Bibliographic Citation
Anaerobe, vol. 64, pp. 102236-102236
Publication Year
2020
Abstract
Clostridium perfringens is ubiquitous in the environment and the gastrointestinal tract of warm-blooded animals. While part of the gut microbiome, abnormal growth of C. perfringens causes histotoxic, neurologic, and enteric diseases in a variety of animal species, including humans, due to the production of toxins. There is extremely limited information on C. perfringens infection in non-human primates. Presently, 10 strains were successfully isolated from 126 monkeys and confirmed by molecular and biochemical analyses. All isolates were genotype A based on molecular analysis. Alpha toxin was identified in all isolates. Beta 2 toxin was detected in only three isolates. No other toxins, including enterotoxin, beta, iota, epsilon, and net B toxin, were identified in any isolate. All isolates were highly susceptible to β-lactam antibiotics. Double hemolysis and lecithinase activity were commonly observed in all strains. Biofilm formation, which can increase antibiotic resistance, was identified in 90% of the isolates. The data are the first report the prevalence and characteristics of C. perfringens isolated from captive cynomolgus monkeys.
Keyword
Clostridium perfringensNon-human primatesCynomolgus monkeysAcute gastric dilatationAntibiotic resistanceBiofilm
ISSN
1075-9964
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.anaerobe.2020.102236
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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