Pinus thunbergii PARL leaf protects against alcohol-induced liver disease by enhancing antioxidant defense mechanism in BALB/c mice

Cited 7 time in scopus
Metadata Downloads
Title
Pinus thunbergii PARL leaf protects against alcohol-induced liver disease by enhancing antioxidant defense mechanism in BALB/c mice
Author(s)
M S Jeong; S Park; E J Han; S Y Park; M J Kim; Kyungsook Jung; S H Cho; S Y Kim; W J Yoon; G Ahn; K N Kim
Bibliographic Citation
Journal of Functional Foods, vol. 73, pp. 104116-104116
Publication Year
2020
Abstract
Pinus thunbergii is a black pine that has been widely used in health-promoting foods. This study was conducted to investigate the hepatoprotective effects of the alcohol-aqueous extract of Pinus thunbergii PARL leaves (PTE) in ethanol-induced liver-damaged mice. PTE increased the weight and survival rate of mice while reducing the levels of serum hepatic marker enzymes. PTE also restored the levels of antioxidant enzymes in liver tissues while drastically increasing lipid peroxidation concentrations. Histopathological examination of PTE-treated mice presented relatively less lipid droplets and hepatic tissue damage compared to ethanol-treated mice. Finally, to identify PTE components, Natural Products Application Solution with UNIFI along with an in-house library was processed and results revealed 35 compounds in the extract. These compounds were reported to exhibit significant antioxidant and/or hepatoprotective properties. Our results suggest that PTE improves liver function and can be developed as a food product with hepatoprotective effects.
Keyword
Alcoholic liver diseasePinus thunbergii PARLHepatoprotective effectSerum hepatic biomarkerAntioxidant enzymes activity
ISSN
1756-4646
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jff.2020.104116
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.