Acyclic triterpenoid isolated from Alpinia katsumadai alleviates formalin-induced chronic mouse paw inflammation by inhibiting the phosphorylation of ERK and NF-κB

Cited 10 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorHyung Jin Lim-
dc.contributor.authorSeon Gyeong Bak-
dc.contributor.authorHee Ju Im-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorSoyoung Lee-
dc.contributor.authorS K Ku-
dc.contributor.authorS I Park-
dc.contributor.authorSeung Jae Lee-
dc.contributor.authorMun Chual Rho-
dc.date.accessioned2020-09-24T03:51:43Z-
dc.date.available2020-09-24T03:51:43Z-
dc.date.issued2020-
dc.identifier.issn1420-3049-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22759-
dc.description.abstractChronic and excessive inflammation can destroy host organs and cause inflammatory diseases such as inflammatory bowel disease, asthma, and rheumatoid arthritis. In this study, we investigated the anti-inflammatory effects of Alpinia katsumadai seed-derived 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (PHT) using lipopolysaccharide (LPS)-stimulated J774 cells and a formalin-induced chronic paw inflammation mouse model. The in vitro results showed that PHT exhibited no cytotoxicity and decreased LPS-induced NO secretion. Additionally, PHT inhibited LPS-induced inducible NO synthase (iNOS) and cyclooxygenase 2 (COX2) protein expression. The quantitative real-time PCR results showed that PHT downregulated the gene expression of the proinflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) but not tumor necrosis factor α (TNF-α). PHT inhibited the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB). In a mouse model, oral administration of 50 mg/kg PHT significantly alleviated both mouse paw thickness and volume. These results indicate that PHT has potential anti-inflammatory effects and should be considered a possible functional material.-
dc.publisherMDPI-
dc.titleAcyclic triterpenoid isolated from Alpinia katsumadai alleviates formalin-induced chronic mouse paw inflammation by inhibiting the phosphorylation of ERK and NF-κB-
dc.title.alternativeAcyclic triterpenoid isolated from Alpinia katsumadai alleviates formalin-induced chronic mouse paw inflammation by inhibiting the phosphorylation of ERK and NF-κB-
dc.typeArticle-
dc.citation.titleMolecules-
dc.citation.number0-
dc.citation.endPage3345-
dc.citation.startPage3345-
dc.citation.volume25-
dc.contributor.affiliatedAuthorHyung Jin Lim-
dc.contributor.affiliatedAuthorSeon Gyeong Bak-
dc.contributor.affiliatedAuthorHee Ju Im-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorSoyoung Lee-
dc.contributor.affiliatedAuthorSeung Jae Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName임형진-
dc.contributor.alternativeName박선경-
dc.contributor.alternativeName임희주-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName이소영-
dc.contributor.alternativeName구새광-
dc.contributor.alternativeName박상익-
dc.contributor.alternativeName이승재-
dc.contributor.alternativeName노문철-
dc.identifier.bibliographicCitationMolecules, vol. 25, pp. 3345-3345-
dc.identifier.doi10.3390/molecules25153345-
dc.subject.keywordAlpinia katsumadai-
dc.subject.keyword2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14, 18-tetraene-
dc.subject.keywordchronic mouse model-
dc.subject.keywordanti-inflammation-
dc.subject.localAlpinia katsumadai-
dc.subject.local2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14, 18-tetraene-
dc.subject.localchronic mouse model-
dc.subject.localantiinflammation-
dc.subject.localAntiinflammation-
dc.subject.localanti-inflammation-
dc.subject.localAnti-Inflammation-
dc.subject.localAnti-inflammation-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.