DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyung Jin Lim | - |
dc.contributor.author | Seon Gyeong Bak | - |
dc.contributor.author | Hee Ju Im | - |
dc.contributor.author | Seung Woong Lee | - |
dc.contributor.author | Soyoung Lee | - |
dc.contributor.author | S K Ku | - |
dc.contributor.author | S I Park | - |
dc.contributor.author | Seung Jae Lee | - |
dc.contributor.author | Mun Chual Rho | - |
dc.date.accessioned | 2020-09-24T03:51:43Z | - |
dc.date.available | 2020-09-24T03:51:43Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/22759 | - |
dc.description.abstract | Chronic and excessive inflammation can destroy host organs and cause inflammatory diseases such as inflammatory bowel disease, asthma, and rheumatoid arthritis. In this study, we investigated the anti-inflammatory effects of Alpinia katsumadai seed-derived 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (PHT) using lipopolysaccharide (LPS)-stimulated J774 cells and a formalin-induced chronic paw inflammation mouse model. The in vitro results showed that PHT exhibited no cytotoxicity and decreased LPS-induced NO secretion. Additionally, PHT inhibited LPS-induced inducible NO synthase (iNOS) and cyclooxygenase 2 (COX2) protein expression. The quantitative real-time PCR results showed that PHT downregulated the gene expression of the proinflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) but not tumor necrosis factor α (TNF-α). PHT inhibited the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB). In a mouse model, oral administration of 50 mg/kg PHT significantly alleviated both mouse paw thickness and volume. These results indicate that PHT has potential anti-inflammatory effects and should be considered a possible functional material. | - |
dc.publisher | MDPI | - |
dc.title | Acyclic triterpenoid isolated from Alpinia katsumadai alleviates formalin-induced chronic mouse paw inflammation by inhibiting the phosphorylation of ERK and NF-κB | - |
dc.title.alternative | Acyclic triterpenoid isolated from Alpinia katsumadai alleviates formalin-induced chronic mouse paw inflammation by inhibiting the phosphorylation of ERK and NF-κB | - |
dc.type | Article | - |
dc.citation.title | Molecules | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 3345 | - |
dc.citation.startPage | 3345 | - |
dc.citation.volume | 25 | - |
dc.contributor.affiliatedAuthor | Hyung Jin Lim | - |
dc.contributor.affiliatedAuthor | Seon Gyeong Bak | - |
dc.contributor.affiliatedAuthor | Hee Ju Im | - |
dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
dc.contributor.affiliatedAuthor | Soyoung Lee | - |
dc.contributor.affiliatedAuthor | Seung Jae Lee | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.alternativeName | 임형진 | - |
dc.contributor.alternativeName | 박선경 | - |
dc.contributor.alternativeName | 임희주 | - |
dc.contributor.alternativeName | 이승웅 | - |
dc.contributor.alternativeName | 이소영 | - |
dc.contributor.alternativeName | 구새광 | - |
dc.contributor.alternativeName | 박상익 | - |
dc.contributor.alternativeName | 이승재 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.identifier.bibliographicCitation | Molecules, vol. 25, pp. 3345-3345 | - |
dc.identifier.doi | 10.3390/molecules25153345 | - |
dc.subject.keyword | Alpinia katsumadai | - |
dc.subject.keyword | 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14, 18-tetraene | - |
dc.subject.keyword | chronic mouse model | - |
dc.subject.keyword | anti-inflammation | - |
dc.subject.local | Alpinia katsumadai | - |
dc.subject.local | 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14, 18-tetraene | - |
dc.subject.local | chronic mouse model | - |
dc.subject.local | antiinflammation | - |
dc.subject.local | Antiinflammation | - |
dc.subject.local | anti-inflammation | - |
dc.subject.local | Anti-Inflammation | - |
dc.subject.local | Anti-inflammation | - |
dc.description.journalClass | Y | - |
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