Neuroprotective effects of cryptotanshinone in a direct reprogramming model of Parkinson's disease

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Title
Neuroprotective effects of cryptotanshinone in a direct reprogramming model of Parkinson's disease
Author(s)
Joo-Eun Lee; Hyuna Sim; H M Yoo; Minhyung Lee; Areum BaekYoung Joo Jeon; K S Seo; Mi Young Son; J S Yoon; Janghwan Kim
Bibliographic Citation
Molecules, vol. 25, no. 16, pp. 3602-3602
Publication Year
2020
Abstract
Parkinson's disease (PD) is a well-known age-related neurodegenerative disease. Considering the vital importance of disease modeling based on reprogramming technology, we adopted direct reprogramming to human-induced neuronal progenitor cells (hiNPCs) for in vitro assessment of potential therapeutics. In this study, we investigated the neuroprotective effects of cryptotanshinone (CTN), which has been reported to have antioxidant properties, through PD patient-derived hiNPCs (PD-iNPCs) model with induced oxidative stress and cell death by the proteasome inhibitor MG132. A cytotoxicity assay showed that CTN possesses anti-apoptotic properties in PD-hiNPCs. CTN treatment significantly reduced cellular apoptosis through mitochondrial restoration, such as the reduction in mitochondrial reactive oxygen species and increments of mitochondrial membrane potential. These effects of CTN are mediated via the nuclear factor erythroid 2-related factor 2 (NRF2) pathway in PD-hiNPCs. Consequently, CTN could be a potential antioxidant reagent for preventing disease-related pathological phenotypes of PD.
Keyword
mitochondrial dysfunctionantioxidantParkinson’s diseasecryptotanshinonedisease modeling
ISSN
1420-3049
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/molecules25163602
Type
Article
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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