DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyun Jae Jang | - |
dc.contributor.author | Kang Hoon Kim | - |
dc.contributor.author | Eun Jae Park | - |
dc.contributor.author | Jeong A Kang | - |
dc.contributor.author | B S Yun | - |
dc.contributor.author | Seung Jae Lee | - |
dc.contributor.author | Chan Sun Park | - |
dc.contributor.author | Soyoung Lee | - |
dc.contributor.author | Seung Woong Lee | - |
dc.contributor.author | Mun Chual Rho | - |
dc.date.accessioned | 2020-09-24T04:00:54Z | - |
dc.date.available | 2020-09-24T04:00:54Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2314-8861 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/22785 | - |
dc.description.abstract | Celastrus orbiculatus Thunb has been known as an ethnopharmacological medicinal plant for antitumor, anti-inflammatory, and analgesic effects. Although various pharmacological studies of C. orbiculatus extract has been reported, an anti-inflammatory mechanism study of their phytochemical constituents has not been fully elucidated. In this study, compounds 1-17, including undescribed podocarpane-type trinorditerpenoid (3), were purified from C. orbiculatus and their chemical structure were determined by high-resolution electrospray ionization mass (HRESIMS) and nuclear magnetic resonance (NMR) spectroscopic data. To investigate the anti-inflammatory activity of compounds 1-17, nitric oxide (NO) secretion was evaluated in LPS-treated murine macrophages, RAW264.7 cells. Among compounds 1-17, deoxynimbidiol (1) and new trinorditerpenoid (3) showed the most potent inhibitory effects (IC50: 4.9 and 12.6 μM, respectively) on lipopolysaccharide- (LPS-) stimulated NO releases as well as proinflammatory mediators, such as inducible nitric oxide (iNOS), cyclooxygenase- (COX-) 2, interleukin- (IL-) 1β, IL-6, and tumor necrosis factor- (TNF-) α. Its inhibitory activity of proinflammatory mediators is contributed by suppressing the activation of nuclear transcription factor- (NF-) κB and mitogen-activated protein kinase (MAPK) signaling cascades including p65, inhibition of NF-κB (IκB), extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38. Therefore, these results demonstrated that diterpenoids 1 and 3 obtained from C. orbiculatus may be considered a potential candidate for the treatment of inflammatory diseases. | - |
dc.publisher | Hindawi Ltd | - |
dc.title | Anti-inflammatory activity of diterpenoids from Celastrus orbiculatus in lipopolysaccharide-stimulated RAW264.7 cells | - |
dc.title.alternative | Anti-inflammatory activity of diterpenoids from Celastrus orbiculatus in lipopolysaccharide-stimulated RAW264.7 cells | - |
dc.type | Article | - |
dc.citation.title | Journal of Immunology Research | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 7207354 | - |
dc.citation.startPage | 7207354 | - |
dc.citation.volume | 2020 | - |
dc.contributor.affiliatedAuthor | Hyun Jae Jang | - |
dc.contributor.affiliatedAuthor | Kang Hoon Kim | - |
dc.contributor.affiliatedAuthor | Eun Jae Park | - |
dc.contributor.affiliatedAuthor | Jeong A Kang | - |
dc.contributor.affiliatedAuthor | Seung Jae Lee | - |
dc.contributor.affiliatedAuthor | Chan Sun Park | - |
dc.contributor.affiliatedAuthor | Soyoung Lee | - |
dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.alternativeName | 장현재 | - |
dc.contributor.alternativeName | 김강훈 | - |
dc.contributor.alternativeName | 박은재 | - |
dc.contributor.alternativeName | 강정아 | - |
dc.contributor.alternativeName | 윤봉식 | - |
dc.contributor.alternativeName | 이승재 | - |
dc.contributor.alternativeName | 박찬선 | - |
dc.contributor.alternativeName | 이소영 | - |
dc.contributor.alternativeName | 이승웅 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.identifier.bibliographicCitation | Journal of Immunology Research, vol. 2020, pp. 7207354-7207354 | - |
dc.identifier.doi | 10.1155/2020/7207354 | - |
dc.description.journalClass | Y | - |
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