Anti-inflammatory activity of diterpenoids from Celastrus orbiculatus in lipopolysaccharide-stimulated RAW264.7 cells

Cited 9 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorHyun Jae Jang-
dc.contributor.authorKang Hoon Kim-
dc.contributor.authorEun Jae Park-
dc.contributor.authorJeong A Kang-
dc.contributor.authorB S Yun-
dc.contributor.authorSeung Jae Lee-
dc.contributor.authorChan Sun Park-
dc.contributor.authorSoyoung Lee-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorMun Chual Rho-
dc.date.accessioned2020-09-24T04:00:54Z-
dc.date.available2020-09-24T04:00:54Z-
dc.date.issued2020-
dc.identifier.issn2314-8861-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22785-
dc.description.abstractCelastrus orbiculatus Thunb has been known as an ethnopharmacological medicinal plant for antitumor, anti-inflammatory, and analgesic effects. Although various pharmacological studies of C. orbiculatus extract has been reported, an anti-inflammatory mechanism study of their phytochemical constituents has not been fully elucidated. In this study, compounds 1-17, including undescribed podocarpane-type trinorditerpenoid (3), were purified from C. orbiculatus and their chemical structure were determined by high-resolution electrospray ionization mass (HRESIMS) and nuclear magnetic resonance (NMR) spectroscopic data. To investigate the anti-inflammatory activity of compounds 1-17, nitric oxide (NO) secretion was evaluated in LPS-treated murine macrophages, RAW264.7 cells. Among compounds 1-17, deoxynimbidiol (1) and new trinorditerpenoid (3) showed the most potent inhibitory effects (IC50: 4.9 and 12.6 μM, respectively) on lipopolysaccharide- (LPS-) stimulated NO releases as well as proinflammatory mediators, such as inducible nitric oxide (iNOS), cyclooxygenase- (COX-) 2, interleukin- (IL-) 1β, IL-6, and tumor necrosis factor- (TNF-) α. Its inhibitory activity of proinflammatory mediators is contributed by suppressing the activation of nuclear transcription factor- (NF-) κB and mitogen-activated protein kinase (MAPK) signaling cascades including p65, inhibition of NF-κB (IκB), extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38. Therefore, these results demonstrated that diterpenoids 1 and 3 obtained from C. orbiculatus may be considered a potential candidate for the treatment of inflammatory diseases.-
dc.publisherHindawi Ltd-
dc.titleAnti-inflammatory activity of diterpenoids from Celastrus orbiculatus in lipopolysaccharide-stimulated RAW264.7 cells-
dc.title.alternativeAnti-inflammatory activity of diterpenoids from Celastrus orbiculatus in lipopolysaccharide-stimulated RAW264.7 cells-
dc.typeArticle-
dc.citation.titleJournal of Immunology Research-
dc.citation.number0-
dc.citation.endPage7207354-
dc.citation.startPage7207354-
dc.citation.volume2020-
dc.contributor.affiliatedAuthorHyun Jae Jang-
dc.contributor.affiliatedAuthorKang Hoon Kim-
dc.contributor.affiliatedAuthorEun Jae Park-
dc.contributor.affiliatedAuthorJeong A Kang-
dc.contributor.affiliatedAuthorSeung Jae Lee-
dc.contributor.affiliatedAuthorChan Sun Park-
dc.contributor.affiliatedAuthorSoyoung Lee-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName김강훈-
dc.contributor.alternativeName박은재-
dc.contributor.alternativeName강정아-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName이승재-
dc.contributor.alternativeName박찬선-
dc.contributor.alternativeName이소영-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName노문철-
dc.identifier.bibliographicCitationJournal of Immunology Research, vol. 2020, pp. 7207354-7207354-
dc.identifier.doi10.1155/2020/7207354-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.