Effect of triclosan exposure on developmental competence in parthenogenetic porcine embryo during preimplantation

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dc.contributor.authorMin Ju Kim-
dc.contributor.authorH J Park-
dc.contributor.authorSanghoon Lee-
dc.contributor.authorHyo-Gu Kang-
dc.contributor.authorPil Soo Jeong-
dc.contributor.authorSoo Hyun Park-
dc.contributor.authorYoung-Ho Park-
dc.contributor.authorJong Hee Lee-
dc.contributor.authorKyung Seob Lim-
dc.contributor.authorSeung Hwan Lee-
dc.contributor.authorBo Woong Sim-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorS K Cho-
dc.contributor.authorD B Koo-
dc.contributor.authorBong-Seok Song-
dc.date.accessioned2020-09-24T04:01:36Z-
dc.date.available2020-09-24T04:01:36Z-
dc.date.issued2020-
dc.identifier.issn14220067-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22787-
dc.description.abstractTriclosan (TCS) is included in various healthcare products because of its antimicrobial activity; therefore, many humans are exposed to TCS daily. While detrimental effects of TCS exposure have been reported in various species and cell types, the effects of TCS exposure on early embryonic development are largely unknown. The aim of this study was to determine if TCS exerts toxic effects during early embryonic development using porcine parthenogenetic embryos in vitro. Porcine parthenogenetic embryos were cultured in in vitro culture medium with 50 or 100 μM TCS for 6 days. Developmental parameters including cleavage and blastocyst formation rates, developmental kinetics, and the number of blastomeres were assessed. To determine the toxic effects of TCS, apoptosis, oxidative stress, and mitochondrial dysfunction were assessed. TCS exposure resulted in a significant decrease in 2-cell rate and blastocyst formation rate, as well as number of blastomeres, but not in the cleavage rate. TCS also increased the number of apoptotic blastomeres and the production of reactive oxygen species. Finally, TCS treatment resulted in a diffuse distribution of mitochondria and decreased the mitochondrial membrane potential. Our results showed that TCS exposure impaired porcine early embryonic development by inducing DNA damage, oxidative stress, and mitochondrial dysfunction.-
dc.publisherMDPI-
dc.titleEffect of triclosan exposure on developmental competence in parthenogenetic porcine embryo during preimplantation-
dc.title.alternativeEffect of triclosan exposure on developmental competence in parthenogenetic porcine embryo during preimplantation-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.number16-
dc.citation.endPage5790-
dc.citation.startPage5790-
dc.citation.volume21-
dc.contributor.affiliatedAuthorMin Ju Kim-
dc.contributor.affiliatedAuthorSanghoon Lee-
dc.contributor.affiliatedAuthorHyo-Gu Kang-
dc.contributor.affiliatedAuthorPil Soo Jeong-
dc.contributor.affiliatedAuthorSoo Hyun Park-
dc.contributor.affiliatedAuthorYoung-Ho Park-
dc.contributor.affiliatedAuthorJong Hee Lee-
dc.contributor.affiliatedAuthorKyung Seob Lim-
dc.contributor.affiliatedAuthorSeung Hwan Lee-
dc.contributor.affiliatedAuthorBo Woong Sim-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorBong-Seok Song-
dc.contributor.alternativeName김민주-
dc.contributor.alternativeName박효진-
dc.contributor.alternativeName이상훈-
dc.contributor.alternativeName강효구-
dc.contributor.alternativeName정필수-
dc.contributor.alternativeName박수현-
dc.contributor.alternativeName박영호-
dc.contributor.alternativeName이종희-
dc.contributor.alternativeName임경섭-
dc.contributor.alternativeName이승환-
dc.contributor.alternativeName심보웅-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName조성근-
dc.contributor.alternativeName구덕본-
dc.contributor.alternativeName송봉석-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, vol. 21, no. 16, pp. 5790-5790-
dc.identifier.doi10.3390/ijms21165790-
dc.subject.keywordtriclosan-
dc.subject.keywordparthenogenetic embryo-
dc.subject.keyworddevelopmental competence-
dc.subject.keywordoxidative stress-
dc.subject.keywordmitochondria dysfunction-
dc.subject.localtriclosan-
dc.subject.localTriclosan-
dc.subject.localparthenogenetic embryo-
dc.subject.localdevelopmental competence-
dc.subject.localDevelopmental competence-
dc.subject.localoxidative stress-
dc.subject.localOxidative stress-
dc.subject.localmitochondria dysfunction-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
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