High-performance portable graphene field-effect transistor device for detecting Gram-positive and -negative bacteria

Cited 42 time in scopus
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dc.contributor.authorKyung Ho Kim-
dc.contributor.authorSeon Joo Park-
dc.contributor.authorChul Soon Park-
dc.contributor.authorSeong Eun Seo-
dc.contributor.authorJiyeon Lee-
dc.contributor.authorJinyeong Kim-
dc.contributor.authorS H Lee-
dc.contributor.authorSoohyun Lee-
dc.contributor.authorJun Seob Kim-
dc.contributor.authorChoong-Min Ryu-
dc.contributor.authorD Yong-
dc.contributor.authorH Yoon-
dc.contributor.authorH S Song-
dc.contributor.authorS H Lee-
dc.contributor.authorOh Seok Kwon-
dc.date.accessioned2020-09-24T04:06:34Z-
dc.date.available2020-09-24T04:06:34Z-
dc.date.issued2020-
dc.identifier.issn0956-5663-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22800-
dc.description.abstractCurrent techniques for Gram-typing and for diagnosing a pathogen at the early infection stage rely on Gram stains, cultures, Enzyme linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), and gene microarrays, which are labor-intensive and time-consuming approaches. In addition, a delayed or imprecise diagnosis of clinical pathogenic bacteria leads to a life-threatening emergency or overuse of antibiotics and a high-rate occurrence of antimicrobial-resistance microbes. Herein, we report high-performance antibiotics (as bioprobes) conjugated graphene micropattern field-effect transistors (ABX-GMFETs) to facilitate on-site Gram-typing and help in the detection of the presence or absence of Gram-negative and -positive bacteria in the samples. The ABX-GMFET platform, which consists of recognition probes and GM transistors conjugated with novel interfacing chemical compounds, was integrated into the microfluidics to minimize the required human intervention and facilitate automation. The mechanism of binding of ABX-GMFET was based on a charge or chemical moiety interaction between the bioprobes and target bacteria. Subsequently, ABX-GMFETs exhibited unprecedented high sensitivity with a limit of detection (LOD) of 100 CFU/mL (1-9 CFU/mL), real-time target specificity.-
dc.publisherElsevier-
dc.titleHigh-performance portable graphene field-effect transistor device for detecting Gram-positive and -negative bacteria-
dc.title.alternativeHigh-performance portable graphene field-effect transistor device for detecting Gram-positive and -negative bacteria-
dc.typeArticle-
dc.citation.titleBiosensors & Bioelectronics-
dc.citation.number0-
dc.citation.endPage112514-
dc.citation.startPage112514-
dc.citation.volume167-
dc.contributor.affiliatedAuthorKyung Ho Kim-
dc.contributor.affiliatedAuthorSeon Joo Park-
dc.contributor.affiliatedAuthorChul Soon Park-
dc.contributor.affiliatedAuthorSeong Eun Seo-
dc.contributor.affiliatedAuthorJiyeon Lee-
dc.contributor.affiliatedAuthorJinyeong Kim-
dc.contributor.affiliatedAuthorSoohyun Lee-
dc.contributor.affiliatedAuthorJun Seob Kim-
dc.contributor.affiliatedAuthorChoong-Min Ryu-
dc.contributor.affiliatedAuthorOh Seok Kwon-
dc.contributor.alternativeName김경호-
dc.contributor.alternativeName박선주-
dc.contributor.alternativeName박철순-
dc.contributor.alternativeName서성은-
dc.contributor.alternativeName이지연-
dc.contributor.alternativeName김진영-
dc.contributor.alternativeName이승환-
dc.contributor.alternativeName이수현-
dc.contributor.alternativeName김준섭-
dc.contributor.alternativeName류충민-
dc.contributor.alternativeName용동은-
dc.contributor.alternativeName윤현석-
dc.contributor.alternativeName송현석-
dc.contributor.alternativeName이상훈-
dc.contributor.alternativeName권오석-
dc.identifier.bibliographicCitationBiosensors & Bioelectronics, vol. 167, pp. 112514-112514-
dc.identifier.doi10.1016/j.bios.2020.112514-
dc.subject.keywordPortable biosensor-
dc.subject.keywordGraphene field-effect transistor-
dc.subject.keywordInterfacing chemistry-
dc.subject.keywordMicrofluidics-
dc.subject.keywordReal-time monitoring-
dc.subject.keywordBioprobes-
dc.subject.localPortable biosensor-
dc.subject.localPortable biosensors-
dc.subject.localGraphene field-effect transistor-
dc.subject.localInterfacing chemistry-
dc.subject.localmicrofluidics-
dc.subject.localMicrofluidics-
dc.subject.localreal-time monitoring-
dc.subject.localReal-time monitoring-
dc.subject.localBioprobes-
dc.subject.localBioprobe-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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