A new nano-platform of erythromycin combined with Ag nano-particle ZnO nano-structure against methicillin-resistant Staphylococcus aureus

Cited 6 time in scopus
Metadata Downloads
Title
A new nano-platform of erythromycin combined with Ag nano-particle ZnO nano-structure against methicillin-resistant Staphylococcus aureus
Author(s)
A Naskar; S Lee; Yunhee Lee; Semi Kim; K S Kim
Bibliographic Citation
Pharmaceutics, vol. 12, no. 9, pp. 841-841
Publication Year
2020
Abstract
Nano-particles have been combined with antibiotics in recent studies to overcome multidrug-resistant bacteria. Here, we synthesized a nano-material in which Ag nano-particles were assembled with a ZnO nano-structure to form an Ag-ZnO (AZO) nano-composite at low temperature. This material was combined with erythromycin (Ery), an antibiotic effective towards gram-positive bacteria, using three different approaches (AZO + Ery (AZE) [centrifuged (AZE1), used separately after 1-h gap (AZE2), without centrifugation (AZE3)]) to prepare a nano-antibiotic against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). X-ray diffraction analysis and transmission electron microscopy confirmed the presence of Ag nano-particles and ZnO nano-structure. The elemental and chemical state of the elements present in the AZO nano-composite were assessed by X-ray photoelectron spectroscopy. The antibacterial activity of AZE samples against both Escherichia coli and S. aureus strains including MRSA was evaluated in antibacterial and morphological analyses. The AZE3 sample showed greater antibacterial activity than the other samples and was comparable to erythromycin. AZE3 was ~20-fold less prone to developing bacterial resistance following multiple exposures to bacteria compared to erythromycin alone. The AZE3 nano-composite showed good biocompatibility with 293 human embryonic kidney cells. Our newly synthesized nano-platform antibiotics may be useful against multidrug-resistant gram-positive bacteria.
Keyword
low-temperature synthesisZnO nano-structureantibacterial activityantibiotic resistancebiocompatibility
ISSN
1999-4923
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/pharmaceutics12090841
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.