Oleanolic acid acetate alleviates symptoms of experimental autoimmune encephalomyelitis in mice by regulating Toll-like receptor 2 signaling

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dc.contributor.authorM Kim-
dc.contributor.authorSoyoung Lee-
dc.contributor.authorHyungJin Lim-
dc.contributor.authorJihye Lee-
dc.contributor.authorJi Young Park-
dc.contributor.authorHyung Jun Kwon-
dc.contributor.authorIn Chul Lee-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorJ Kim-
dc.contributor.authorT Shin-
dc.contributor.authorG Ahn-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorKyungsook Jung-
dc.date.accessioned2020-09-24T04:11:52Z-
dc.date.available2020-09-24T04:11:52Z-
dc.date.issued2020-
dc.identifier.issn16639812-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22814-
dc.description.abstractToll-like receptor 2 (TLR2) is expressed by several immune cells in the central nervous system and plays an important role in neuroinflammation. TLR2 upregulation has been reported in multiple sclerosis patients and in experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis. Therefore, modulating TLR2 signaling can be an effective treatment strategy against MS. Oleanolic acid acetate (OAA) has antiinflammatory and immunomodulatory effects. Hence, this study aimed to examine the effects of OAA on TLR2 signaling and neuroinflammation in EAE. EAE was induced in C57/BL6 mice using synthesized myelin oligodendrocyte glycoprotein (MOG)35-55 peptide, and OAA was administered daily. Hind limb paralysis and inflammatory cell infiltration were observed in the spinal cords of EAE mice. Moreover, T-cell proliferation was significantly stimulated in splenic cells from EAE mice. The expression of proinflammatory cytokines in the spinal cord was upregulated, and their serum protein levels were increased in EAE mice. Furthermore, upregulation of TLR2 and downstream signaling molecules was observed in the spinal cord. These pathological changes were reversed by OAA treatment. Our results suggest that OAA might have promising therapeutic properties and that the TLR signaling pathway is an effective therapeutic target against multiple sclerosis.-
dc.publisherFrontiers Media Sa-
dc.titleOleanolic acid acetate alleviates symptoms of experimental autoimmune encephalomyelitis in mice by regulating Toll-like receptor 2 signaling-
dc.title.alternativeOleanolic acid acetate alleviates symptoms of experimental autoimmune encephalomyelitis in mice by regulating Toll-like receptor 2 signaling-
dc.typeArticle-
dc.citation.titleFrontiers in Pharmacology-
dc.citation.number0-
dc.citation.endPage556391-
dc.citation.startPage556391-
dc.citation.volume11-
dc.contributor.affiliatedAuthorSoyoung Lee-
dc.contributor.affiliatedAuthorHyungJin Lim-
dc.contributor.affiliatedAuthorJihye Lee-
dc.contributor.affiliatedAuthorJi Young Park-
dc.contributor.affiliatedAuthorHyung Jun Kwon-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorKyungsook Jung-
dc.contributor.alternativeName김민주-
dc.contributor.alternativeName이소영-
dc.contributor.alternativeName임형진-
dc.contributor.alternativeName이지혜-
dc.contributor.alternativeName박지영-
dc.contributor.alternativeName권형준-
dc.contributor.alternativeName이인철-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName김정태-
dc.contributor.alternativeName신태균-
dc.contributor.alternativeName안긴내-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName정경숙-
dc.identifier.bibliographicCitationFrontiers in Pharmacology, vol. 11, pp. 556391-556391-
dc.identifier.doi10.3389/fphar.2020.556391-
dc.subject.keywordmultiple sclerosis-
dc.subject.keywordexperimental autoimmune encephalomyelitis-
dc.subject.keywordoleanolic acid acetate-
dc.subject.keywordToll-like receptor 2-
dc.subject.keywordinflammation-
dc.subject.localmultiple sclerosis-
dc.subject.localMultiple sclerosis-
dc.subject.localexperimental autoimmune encephalomyelitis-
dc.subject.localExperimental autoimmune encephalomyelitis-
dc.subject.localoleanolic acid acetate-
dc.subject.localOleanolic acid acetate-
dc.subject.localToll-like receptor 2-
dc.subject.localinflammation-
dc.subject.localInflammation-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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