벨벳애플 추출물을 유효성분으로 함유하는 염증성 질환 또는 알레르기 질환의 예방 및 치료용 약학적 조성물

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Title
벨벳애플 추출물을 유효성분으로 함유하는 염증성 질환 또는 알레르기 질환의 예방 및 치료용 약학적 조성물
Alternative Title
Pharmaceutical composition for prevention and treatment of inflammatory or allergic diseases comprising extract of Diospyros blancoi A. DC. as an active ingredient
Inventor(s)
오세량안경섭김수용김정희권옥경; 이형규
Assignee(s)
한국생명공학연구원
Application No.
13/820,474 (2013.03.01)
Registration No.
8,722,110 (2014.05.13)
Country
미국
Abstract
Disclosed is a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma, comprising a velvet apple (Diospyros blancoi A. DC.) extract as an active ingredient. Having the inhibitory activity against the nuclear translocation of NF-κB, whose level is rapidly elevated in response to inflammatory stimuli, the velvet apple extract can suppress the production of NO and PGE2, the expression of iNOS and COX-2, and the release of IL-1β and TNF-α, and can significantly down regulate Th2-mediated IL-4 and IL-13 production. In addition, the extract was found to inhibit the activation of eosinophils in bronchoalveolar lavage fluid, and to suppress the secretion of immunoglobulins and chemokines in bronchoalveolar lavage fluid and blood, as measured by in vivo tests on an ovalbumin-induced asthma mouse model. Therefore, the extract can be used in the method for preventing or treating various inflammatory disorders, allergic diseases, or asthma.
Type
Patent
Appears in Collections:
Ochang Branch Institute > 2. Patents
Ochang Branch Institute > Natural Medicine Research Center > 2. Patents
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 2. Patents
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