DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ji Won Park | - |
dc.contributor.author | Seong-Man Kim | - |
dc.contributor.author | Jae-Hong Min | - |
dc.contributor.author | Min-Gu Kim | - |
dc.contributor.author | Ok-Kyoung Kwon | - |
dc.contributor.author | Daseul Hwang | - |
dc.contributor.author | Jae-Hoon Oh | - |
dc.contributor.author | M W Park | - |
dc.contributor.author | W Chun | - |
dc.contributor.author | H J Lee | - |
dc.contributor.author | Doo-Young Kim | - |
dc.contributor.author | Jung Hee Kim | - |
dc.contributor.author | Joonsung Hwang | - |
dc.contributor.author | Mun-Ock Kim | - |
dc.contributor.author | Sei-Ryang Oh | - |
dc.contributor.author | Kyung Seop Ahn | - |
dc.contributor.author | Jae Won Lee | - |
dc.date.accessioned | 2020-10-04T13:14:18Z | - |
dc.date.available | 2020-10-04T13:14:18Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/22906 | - |
dc.description.abstract | 3,4,5-Trihydroxycinnamic acid (THCA) has been reported to possess anti-inflammatory activity. However, the effect of THCA for treating allergic asthma was unknown. Therefore, in the present study, the anti-asthmatic effects of THCA were studied in both in vitro and in vivo studies. In phorbol 12-myristate 13-acetate (PMA)-stimulated A549 airway epithelial cells, THCA pretreatment decreased the mRNA expression and secretion of interleukin (IL)-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1), and reduced the mRNA expression of matrix metalloproteinase 9 (MMP-9). THCA also inhibited PMA-induced protein kinase B (AKT), mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) activation in A549 cells. In lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, THCA pretreatment suppressed the mRNA expression of ICAM-1 and MMP-9. In addition, THCA suppressed the adhesion of EOL and A549 cells. In ovalbumin (OVA)-administered asthmatic mice, THCA exerted inhibitory activity on IL-5, IL-13, and MCP-1 in bronchoalveolar lavage fluid (BALF) and on OVA-specific immunoglobulin E (IgE) in serum. THCA attenuated the numbers of inflammatory cells in BALF and the influx of inflammatory cell in lung tissues. Furthermore, THCA downregulated the levels of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2), and leukotriene B4 (LTB4) expression, mucus production and CREB phosphorylation as well as Penh value. These effects were accompanied by suppression of AKT, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and NF-κB activation. Therefore, the results of the current study suggest that THCA may be a valuable adjuvant or therapeutic in the prevention or treatment of allergic asthma | - |
dc.publisher | Elsevier | - |
dc.title | 3,4,5-Trihydroxycinnamic acid exerts anti-asthmatic effects in vitro and in vivo | - |
dc.title.alternative | 3,4,5-Trihydroxycinnamic acid exerts anti-asthmatic effects in vitro and in vivo | - |
dc.type | Article | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 107002 | - |
dc.citation.startPage | 107002 | - |
dc.citation.volume | 88 | - |
dc.contributor.affiliatedAuthor | Ji Won Park | - |
dc.contributor.affiliatedAuthor | Seong-Man Kim | - |
dc.contributor.affiliatedAuthor | Jae-Hong Min | - |
dc.contributor.affiliatedAuthor | Min-Gu Kim | - |
dc.contributor.affiliatedAuthor | Ok-Kyoung Kwon | - |
dc.contributor.affiliatedAuthor | Daseul Hwang | - |
dc.contributor.affiliatedAuthor | Jae-Hoon Oh | - |
dc.contributor.affiliatedAuthor | Doo-Young Kim | - |
dc.contributor.affiliatedAuthor | Jung Hee Kim | - |
dc.contributor.affiliatedAuthor | Joonsung Hwang | - |
dc.contributor.affiliatedAuthor | Mun-Ock Kim | - |
dc.contributor.affiliatedAuthor | Sei-Ryang Oh | - |
dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
dc.contributor.affiliatedAuthor | Jae Won Lee | - |
dc.contributor.alternativeName | 박지원 | - |
dc.contributor.alternativeName | 김성만 | - |
dc.contributor.alternativeName | 민재홍 | - |
dc.contributor.alternativeName | 김민구 | - |
dc.contributor.alternativeName | 권옥경 | - |
dc.contributor.alternativeName | 황다슬 | - |
dc.contributor.alternativeName | 오재훈 | - |
dc.contributor.alternativeName | 박민우 | - |
dc.contributor.alternativeName | 천완주 | - |
dc.contributor.alternativeName | 이희재 | - |
dc.contributor.alternativeName | 김두영 | - |
dc.contributor.alternativeName | 김정희 | - |
dc.contributor.alternativeName | 황준성 | - |
dc.contributor.alternativeName | 김문옥 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 안경섭 | - |
dc.contributor.alternativeName | 이재원 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, vol. 88, pp. 107002-107002 | - |
dc.identifier.doi | 10.1016/j.intimp.2020.107002 | - |
dc.subject.keyword | Allergic asthma | - |
dc.subject.keyword | Eosinophil | - |
dc.subject.keyword | THCA | - |
dc.subject.keyword | ICAM-1 | - |
dc.subject.keyword | MMP-9 | - |
dc.subject.keyword | Th2 cytokines | - |
dc.subject.local | Allergic asthma | - |
dc.subject.local | allergic asthma | - |
dc.subject.local | eosinophil | - |
dc.subject.local | Eosinophil | - |
dc.subject.local | Eosinophils | - |
dc.subject.local | THCA | - |
dc.subject.local | ICAM-1 | - |
dc.subject.local | MMP-9 | - |
dc.subject.local | MMP9 | - |
dc.subject.local | MMP-9 (Matrix metalloproteinase) | - |
dc.subject.local | Th2 cytokines | - |
dc.description.journalClass | Y | - |
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