Biflavonoid-rich fraction from Daphne pseudomezereum var. koreana Hamaya exerts anti-inflammatory effect in an experimental animal model of allergic asthma

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dc.contributor.authorJae Won Lee-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorDoo-Young Kim-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorHyun Jae Jang-
dc.contributor.authorH J Kwon-
dc.contributor.authorS Y Kim-
dc.contributor.authorSu Ui Lee-
dc.contributor.authorSung-Man Kim-
dc.contributor.authorEun Sol Oh-
dc.contributor.authorHye In Ahn-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorSei-Ryang Oh-
dc.date.accessioned2020-10-04T13:14:38Z-
dc.date.available2020-10-04T13:14:38Z-
dc.date.issued2021-
dc.identifier.issn0378-8741-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22907-
dc.description.abstractEthnopharmacological relevance: Daphne pseudomezereum var. koreana Hamaya is distributed in the Gangwon-do of South Korea and is traditionally used to treat chronic inflammatory diseases, including rheumatoid arthritis. Aim of the study: We investigated the anti-inflammatory effect of biflavonoid-rich fraction (BF) obtained from an extract of D. pseudomezereum leaves on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and mouse model of ovalbumin (OVA)-induced allergic asthma. Materials and methods: Neochamaejasmin B (NB) and chamaejasmin D (CD) were spectroscopically characterized as major components of BF obtained from the leaves of D. pseudomezereum. RAW264.7 cells pretreated with NB, CD and BF and activated by LPS (500 ng/ml) were used to assess the anti-inflammatory effects of these materials in vitro. To evaluate the protective effect of BF on allergic asthma, female BALB/c mice were sensitized to OVA by intraperitoneal (i.p.) injection and treated with BF by oral administration (15 or 30 mg/kg). Results: Pretreatment with BF inhibited LPS-stimulated nitric oxide (NO), TNF-α and IL-6, and led to upregulation of heme oxygenase-1 (HO-1) in RAW264.7 macrophages. Orally administered BF significantly inhibited the recruitment of eosinophils and the production of IL-5, IL-6, IL-13 and MCP-1 as judged by the analysis of BALF from OVA-induced asthma animal model. BF also decreased the levels of IgE in the serum of asthmatic mice. BF suppressed the influx of inflammatory cells into nearby airways and the hypersecretion of mucus by the airway epithelium of asthmatic mice. In addition, the increase in Penh in asthmatic mice was reduced by BF administration. Furthermore, BF led to Nrf2 activation and HO-1 induction in the lungs of mice. Conclusions: These data have shown the anti-asthmatic effects of BF, and therefore we expect that BF may be a potential candidate as a natural drug/nutraceutical for the prevention and treatment of allergic asthma.-
dc.publisherElsevier-
dc.titleBiflavonoid-rich fraction from Daphne pseudomezereum var. koreana Hamaya exerts anti-inflammatory effect in an experimental animal model of allergic asthma-
dc.title.alternativeBiflavonoid-rich fraction from Daphne pseudomezereum var. koreana Hamaya exerts anti-inflammatory effect in an experimental animal model of allergic asthma-
dc.typeArticle-
dc.citation.titleJournal of Ethnopharmacology-
dc.citation.number0-
dc.citation.endPage113386-
dc.citation.startPage113386-
dc.citation.volume265-
dc.contributor.affiliatedAuthorJae Won Lee-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorDoo-Young Kim-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorHyun Jae Jang-
dc.contributor.affiliatedAuthorSu Ui Lee-
dc.contributor.affiliatedAuthorSung-Man Kim-
dc.contributor.affiliatedAuthorEun Sol Oh-
dc.contributor.affiliatedAuthorHye In Ahn-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.alternativeName이재원-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName김두영-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName권혁준-
dc.contributor.alternativeName김수영-
dc.contributor.alternativeName이수의-
dc.contributor.alternativeName김성만-
dc.contributor.alternativeName오은솔-
dc.contributor.alternativeName안혜인-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName오세량-
dc.identifier.bibliographicCitationJournal of Ethnopharmacology, vol. 265, pp. 113386-113386-
dc.identifier.doi10.1016/j.jep.2020.113386-
dc.subject.keywordAllergic asthma-
dc.subject.keywordEosinophils-
dc.subject.keywordAirway inflammation-
dc.subject.keywordMucus hypersecretion-
dc.subject.keywordDaphne pseudomezereum var. Koreana hamaya-
dc.subject.localAllergic asthma-
dc.subject.localallergic asthma-
dc.subject.localeosinophil-
dc.subject.localEosinophil-
dc.subject.localEosinophils-
dc.subject.localairway inflammation-
dc.subject.localAirway Inflammation-
dc.subject.localAirway inflammation-
dc.subject.localMucus hyper-secretion-
dc.subject.localmucus hypersecretion-
dc.subject.localMucus hypersecretion-
dc.subject.localDaphne pseudomezereum var. Koreana hamaya-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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